Results 121 to 130 of about 366,025 (373)

EMT is not required for lung metastasis but contributes to chemoresistance

Nature, 2015
The role of epithelial-to-mesenchymal transition (EMT) in metastasis is a longstanding source of debate, largely owing to an inability to monitor transient and reversible EMT phenotypes in vivo.
Kari R. Fischer, A. Durrans, Sharrell B Lee, J. Sheng, Fuhai Li, Stephen T. C. Wong, Hyejin Choi, Tina El Rayes, S. Ryu, Juliane S. Troeger, R. Schwabe, L. Vahdat, N. Altorki, V. Mittal, Dingcheng Gao   +14 more
semanticscholar   +1 more source

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

Advanced Science, EarlyView.
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong, Di Wang, Haoze Song, Ting Sun, Yanhong Zhao, Wenjing Gu, Lexuan Lin, Yitong Zhao, Yipeng Liang, Xu Jin, Rongfeng Fu, Mankai Ju, Jie Gao, Jinfa Ma, Chengjie Gao, Anqi Zhang, Zhijian Xiao, Erlie Jiang, Renchi Yang, Shihui Ma, Lei Zhang, Lihong Shi   +21 more
wiley   +1 more source

Supplementary Figure 1 from p53–Pirh2 Complex Promotes Twist1 Degradation and Inhibits EMT [PDF]

, 2023
Yang Yang‐Hartwich, Roslyn Tedja, Cai M. Roberts, Jamie Goodner-Bingham, Carlos Cárdenas, Marta Gurea, Natália J. Sumi, Ayesha B. Alvero, Carlotta A. Glackin, Gil Mor   +9 more
openalex   +2 more sources

Laser-driven proton sources for efficient radiation testing

Scientific Reports
Several fields such as particle physics, space exploration, and high-energy physics, use Commercial Off-The-Shelf (COTS) electronic components in a high-radiation operative environment.
Beatrice D’Orsi, Corrado Altomare, Alessandro Ampollini, Maria Denise Astorino, Giulia Bazzano, Elias Catrix, Alessia Cemmi, Andrea Colangeli, Ilaria Di Sarcina, Daniele Salvatore Lazzaro, Ronan Lelièvre, Stefano Loreti, Sylvain Fourmaux, Julien Fuchs, Paolo Nenzi, Guglielmo Pagano, Fabio Panza, Concetta Ronsivalle, Jessica Scifo, Simon Vallières, Patrizio Antici   +20 more
doaj   +1 more source

Real-time gap-free dynamic waveform spectral analysis with nanosecond resolutions through analog signal processing

Nature Communications, 2020
Real-time dynamic Fourier analysis of high-speed signals is difficult using either digital or analog schemes. Here, the authors present a universal analog approach that can track the changing frequency spectrum of waveforms in a real-time fashion at the ...
Saikrishna Reddy Konatham, Reza Maram, Luis Romero Cortés, Jun Ho Chang, Leslie Rusch, Sophie LaRochelle, Hugues Guillet de Chatellus, José Azaña   +7 more
doaj   +1 more source

Fine-tuning miR-21 expression and inhibition of EMT in breast cancer cells using aromatic-neomycin derivatives [PDF]

, 2021
Arpita Ghosh, Nihar Ranjan, Liuwei Jiang, Asgar Hussain Ansari, Natalya Degyatoreva, Shivaksh Ahluwalia, Dev P. Arya, Souvik Maiti   +7 more
openalex   +1 more source

Rupestonic Acid of Artemisia Rupestris L. Extract Treats Pulmonary Fibrosis in COPD by Targeting TGF‐β1

Advanced Science, EarlyView.
RA of EEAR inhibits TGF‐β1 ubiquitination and changes conformation by target binding TGF‐β1, regulating TGF‐β1/Smad2/3 signaling pathway. Thus it down‐regulated downstream protein expression, inhibited EMT and collagen deposition of ECM, in order to EEAR preventing PF in COPD.
Lingfeng Peng, Lulu Zhang, Yimeng Fan, Sijuan Huang, Qingyu Zhao, Chao Han, Zhihui Hao   +6 more
wiley   +1 more source

Electrification of Madrid Fleet Public Transport Company (EMT-Madrid): Strategic Analysis and Implementation

International Journal of Production Management and Engineering, 2019
Madrid Public Transport Company (EMT-Madrid) is a property of the Madrid City Council, and it provides the public buses service in the whole city.
J. García Hernanz, G. Morales-Alonso, G. Fernández Sánchez, E. Pilkington González, T. Sánchez Chaparro   +4 more
doaj   +1 more source

EMT in immuno-resistance

Oncoscience, 2015
Although the advent of new immunotherapy approaches has improved survival for many patients with advanced malignancies, the high degree of non-responders, especially in highly prevalent malignancies including breast, colon and prostate cancers was also a strong reminder that we possess only partial understanding of the events underlying the immune ...
Stéphane, Terry, Salem, Chouaib
openaire   +2 more sources

YKT6 Promotes Bladder Cancer Progression by Stabilizing β‐catenin Through USP7‐Mediated Deubiquitination

Advanced Science, EarlyView.
The SNARE protein YKT6 is upregulated in bladder cancer (BLCA), correlating with poor prognosis. YKT6 promotes tumor proliferation and metastasis by activating Wnt/β‐catenin signaling. It recruits Ubiquitin‐Specific Peptidase 7 (USP7) to deubiquitinate and stabilize β‐catenin, enhancing its nuclear accumulation and driving oncogenic gene expression ...
Sheng Tu, Wenzhi Du, Yongwen Luo, Jiageng Shi, Tianyun Liu, Meng Ji, Kangping Xiong, Siming Chen, Fenfang Zhou, Mingxing Li, Jingtian Yu, Gang Wang, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Kaiyu Qian   +16 more
wiley   +1 more source