Results 121 to 130 of about 213,806 (248)

The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis

Advanced Science, EarlyView.
SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo, Yalin Wang, Binyu Lu, Yu Zhang, David M. Frazer, Bing Zhou   +5 more
wiley   +1 more source

Space-time couplings in ultrashort lasers with arbitrary nonparaxial focusing

Nanophotonics
Space-time separability is commonly assumed in the theoretical description of laser beams. However, recent progresses have demonstrated that this assumption often breaks down for ultrashort realistic pulses, giving rise to spatio-temporal effects that ...
Jolly Spencer W., Lytova Marianna, Vallières Simon, Légaré François, MacLean Steve, Fillion-Gourdeau François   +5 more
doaj   +1 more source

Oral Streptococcus salivarius Couples Neutrophil IRGM1 Signaling to NET Formation and Colorectal Cancer Metastasis

Advanced Science, EarlyView.
The oral bacterium Streptococcus salivarius promotes colorectal cancer metastasis by inducing neutrophil extracellular trap (NET) formation. Mechanistically, IRGM1–IQGAP1 interaction activates Wnt5a–PI3K/AKT signaling in neutrophils, driving NET‐mediated tumor progression.
Fengyi Liu, Yuan Wang, Hengxuan Cai, Qianwen Yue, Xueli Liu, Xuanwen Bao, Zeng Wang, Xuehan Li, Lai Wei, Zhihua Zhang, Fan Xing, Yi Xu, Xianjun Li, Wei Xu   +13 more
wiley   +1 more source

ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment

Advanced Science, EarlyView.
ETV4 coordinates a dual transcriptional program by upregulating MET and asparagine synthetase (ASNS). The resulting asparagine (Asn) secretion acts as a metabolic signal, reprogramming hepatic stellate cells (HSCs) and primary cancer‐associated fibroblasts (CAFs) toward an inflammatory phenotype. These activated stromal cells release HGF to sustain the
Dujiang Fu, Meijia Zhang, Maoping Cai, Miao Wang, Ziao Huang, Zesheng Lin, Yixin Liu, Wang Qian, Guopeng Chen, Yuxing Liang, Dongyi Wei, Jing xie, Picheng Yan, Yuanyuan Qu, Yongchang Wei   +14 more
wiley   +1 more source

Direct Observation of Carbonate Chemisorption on Barium Titanate Surfaces by Tip‐Enhanced Raman Spectroscopy

Advanced Materials Interfaces
Surface chemistry significantly influences the physicochemical and functional properties of nanoparticles, thus necessitating the investigation of surfaces, especially when subjected to chemisorption.
Mohammad Bakhtbidar, Ifeanyichukwu Amaechi, Andreas Dörfler, Alexandre Merlen, Andreas Ruediger   +4 more
doaj   +1 more source

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Speaker Diarization: A Review of Objectives and Methods

Applied Sciences
Recorded audio often contains speech from multiple people in conversation. It is useful to label such signals with speaker turns, noting when each speaker is talking and identifying each speaker.
Douglas O’Shaughnessy
doaj   +1 more source

Sphingomonas paucimobilis‐Driven Epithelial–Endothelial Transition in Adenomyosis Pathogenesis

Advanced Science, EarlyView.
This study identifies epithelial–endothelial transition (EET) as a novel adenomyosis pathogenic mechanism driven by Sphingomonas paucimobilis colonization. Systematic inhibitor experiments validate a TNFα→NF‐κB→MMP signaling cascade essential for EET. Critically, bacterial culture supernatant fails to induce pathological changes, demonstrating viable ...
Peigen Chen, Hao Shi, Junxian He, Ziyu Liu, Yuanyuan Zhu, Xiaoyan Liang, Guihua Liu, Xing Yang   +7 more
wiley   +1 more source

Self‐Recovery of Carbonate‐Contaminated Strontium Titanate (100) Vicinal Surfaces Imaged by Tip‐Enhanced Raman Spectroscopy

Advanced Materials Interfaces
Strontium titanate (SrTiO3) as a model perovskite has significant applications in catalysis, carbon capture, and advanced electronics. On SrO‐terminated (100) surfaces, carbon dioxide (CO2) is a common chemisorption, altering the electronic and chemical ...
Mohammad Bakhtbidar, Daniel Gueckelhorn, Marivi Fernández‐Serra, Yon Leandro Leibas López, Alexandre Merlen, Andreas Ruediger   +5 more
doaj   +1 more source

Integration of Carbon Nanotubes into Manganese Dioxide Nanorods for Enhanced Enzymeless Electrochemical Glucose Sensing with High Sensitivity and Selectivity

Biosensors
Freestanding electrode designs, cost-effective catalysts, and enhanced electrical conductivity are crucial for improving the performance of fourth-generation non-enzymatic glucose electrochemical sensors.
Khawtar Hasan Ahmed, Alonso Moreno Zuria, Mohamed Mohamedi   +2 more
doaj   +1 more source