Results 121 to 130 of about 338,860 (400)
EMT is not required for lung metastasis but contributes to chemoresistance
Nature, 2015 The role of epithelial-to-mesenchymal transition (EMT) in metastasis is a longstanding source of debate, largely owing to an inability to monitor transient and reversible EMT phenotypes in vivo.
Kari R. Fischer +14 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Nature Communications, 2018 Producing versatile radio-frequency chirped waveforms often requires complicated techniques. The authors use a fiber-optic frequency-shifting loop to create a low-complexity photonic chirp generator with high bandwidth and fully flexible properties for ...
Hugues Guillet de Chatellus +4 more
doaj +1 more source
Aitken-Schwarz heterogeneous Domain Decomposition for EMT-TS Simulation [PDF]
Lecture Notes in Computational Science and Engineering (LNCSE,
volume 145), 2023, 2021 In this paper, a Schwarz heterogeneous domain decomposition method (DDM) is used to co-simulate an RLC electrical circuit where a part of the domain is modeled with Electro-Magnetic Transients (EMT) modeling and the other part with dynamic phasor (TS) modeling.
arxiv
Why Effective Medium Theory Fails in Granular Materials
, 1999 Experimentally it is known that the bulk modulus, K, and shear modulus, \mu, of a granular assembly of elastic spheres increase with pressure, p, faster than the p^1/3 law predicted by effective medium theory (EMT) based on Hertz-Mindlin contact forces ...
A. V. Tkachenko +21 more
core +1 more source
Prickle1 is required for EMT and migration of zebrafish cranial neural crest [PDF]
, 2019 The neural crest—a key innovation of the vertebrates—gives rise to diverse cell types including melanocytes, neurons and glia of the peripheral nervous system, and chondrocytes of the jaw and skull.
Ahsan, Kamil +4 more
core +1 more source
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Scientific Reports, 2017 The polarity of microtubules is thought to be involved in spindle assembly, cytokinesis or active molecular transport. However, its exact role remains poorly understood, mainly because of the challenge to measure microtubule polarity in intact cells.
S. Bancelin +5 more
doaj +1 more source
Epigenetic control of EMT/MET dynamics: HNF4α impacts DNMT3s through miRs-29 [PDF]
, 2015 Background and aims: Epithelial-to-mesenchymal transition (EMT) and the reverse mesenchymal-to-epithelial transition (MET) are manifestations of cellular plasticity that imply a dynamic and profound gene expression reprogramming.
Amicone, Laura +9 more
core +1 more source
Targeting Epithelial–Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer
Molecules, 2016 Epithelial–mesenchymal transition (EMT) is known to play an important role in cancer progression, metastasis and drug resistance. Although there are controversies surrounding the causal relationship between EMT and cancer metastasis, the role of EMT in ...
Bowen Du, J. Shim
semanticscholar +1 more source