Results 81 to 90 of about 213,806 (248)

Targeting EMT in Cancer with Repurposed Metabolic Inhibitors.

Trends in Cancer, 2020
Epithelial-to-mesenchymal transition (EMT) determines the most lethal features of cancer, metastasis formation and chemoresistance, and therefore represents an attractive target in oncology. However, direct targeting of EMT effector molecules is, in most
Vignesh Ramesh, T. Brabletz, P. Ceppi
semanticscholar   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Electrical Conductivities of Conductors, Semiconductors, and Their Mixtures at Elevated Temperatures

Advanced Engineering Materials, EarlyView.
This article presents a comprehensive review of temperature‐dependent electrical conductivity data for multiple material classes at elevated temperatures, highlighting a persistent conductivity gap between metals and semiconductors in the range of 102$\left(10\right)^{2}$– 107$\left(10\right)^{7}$ S/m. Metal–ceramic irregular metamaterials are proposed
Valentina Torres Nieto, Marcia A. Cooper
wiley   +1 more source

Mechanoregulatory Effects of Cell‐Scale Microwells on Epithelial Cell Phenotype

Advanced Functional Materials, EarlyView.
In small polycaprolactone microwells, A549 epithelial cells span well edges, in contrast to cells growing on flat substrates. Focal adhesion sites (yellow) concentrate at topographic boundaries, while cytoskeletal tension (magenta stress fibers) is transmitted to the nucleus (blue), reducing nuclear sphericity.
Ruiwen He, Wang Sik Lee, Phattadon Yajan, Aaron Lee, Mauro Sousa de Almeida, Sandeep Keshavan, Jozef Adamcik, Céline Loussert‐Fonta, Dimitri Vanhecke, Barbara Rothen‐Rutishauser, Alke Petri‐Fink   +10 more
wiley   +1 more source

Real-time gap-free dynamic waveform spectral analysis with nanosecond resolutions through analog signal processing

Nature Communications, 2020
Real-time dynamic Fourier analysis of high-speed signals is difficult using either digital or analog schemes. Here, the authors present a universal analog approach that can track the changing frequency spectrum of waveforms in a real-time fashion at the ...
Saikrishna Reddy Konatham, Reza Maram, Luis Romero Cortés, Jun Ho Chang, Leslie Rusch, Sophie LaRochelle, Hugues Guillet de Chatellus, José Azaña   +7 more
doaj   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Laser-driven proton sources for efficient radiation testing

Scientific Reports
Several fields such as particle physics, space exploration, and high-energy physics, use Commercial Off-The-Shelf (COTS) electronic components in a high-radiation operative environment.
Beatrice D’Orsi, Corrado Altomare, Alessandro Ampollini, Maria Denise Astorino, Giulia Bazzano, Elias Catrix, Alessia Cemmi, Andrea Colangeli, Ilaria Di Sarcina, Daniele Salvatore Lazzaro, Ronan Lelièvre, Stefano Loreti, Sylvain Fourmaux, Julien Fuchs, Paolo Nenzi, Guglielmo Pagano, Fabio Panza, Concetta Ronsivalle, Jessica Scifo, Simon Vallières, Patrizio Antici   +20 more
doaj   +1 more source

Common Signatures of Altered Gene Regulation and Invasiveness of Different Breast Cancer Cell Lines after Matrix Interface Crossing

Advanced Healthcare Materials, EarlyView.
Interface transmigration reprograms triple‐negative breast cancer cells, triggering a shared switch toward more aggressive and invasive phenotypes. Using a collagen I interface model, this study identifies shared transcriptional changes involving proliferation, chromatin remodeling, and DNA repair pathways.
Cornelia Clemens, Hannah Trampert, Nataliia Kotsiuba, Tilo Pompe   +3 more
wiley   +1 more source

Electrification of Madrid Fleet Public Transport Company (EMT-Madrid): Strategic Analysis and Implementation

International Journal of Production Management and Engineering, 2019
Madrid Public Transport Company (EMT-Madrid) is a property of the Madrid City Council, and it provides the public buses service in the whole city.
J. García Hernanz, G. Morales-Alonso, G. Fernández Sánchez, E. Pilkington González, T. Sánchez Chaparro   +4 more
doaj   +1 more source