Results 91 to 100 of about 22,476 (217)
, 2014 A. Representative Western blots. α (90 kDa), β (95 kDa) and γ ENaC protein signals are found in blots probed with specific antibodies against α (Santa Cruz, sc-22239), β (Santa Cruz, sc-21013), and γ (Abcam, ab3468) subunits. B.
Meimi Zhao (646568) +7 more
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The Role of ENaC in Hypernatremia
The FASEB Journal, 2013 ENaC in renal physiology controls sodium excretion to achieve blood pressure regulation through the renin‐angiotensin‐aldosterone system. Our recent findings suggest an additional aspect to this channel's regulation of sodium and water homeostasis.
Elena Mironova +2 more
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, 2014 Cell surface cleavage of γ-ENaC was assessed biochemically using purified AP and AP Inh. A, a cartoon schematic of the ENaC channel is shown with the α-, β-, and γ-subunits labeled.
Xiaoning Liu (588784) +4 more
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Communications BiologyThe epithelial sodium channel (ENaC) is essential for osmoregulation in tetrapod vertebrates. There are four ENaC-subunits (α, β, γ, δ) which form αβγ- or δβγ-ENaCs. While αβγ-ENaC is a ‘maintenance protein’ controlling sodium homeostasis, δβγ-ENaC might
Fynn Zahnow +14 more
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Ubiquitination of renal ENaC subunits in vivo
American Journal of Physiology-Renal Physiology, 2020 Ubiquitination of the epithelial Na+channel (ENaC) in epithelial cells may influence trafficking and hormonal regulation of the channels. We assessed ENaC ubiquitination (ub-ENaC) in mouse and rat kidneys using affinity beads to capture ubiquitinated proteins from tissue homogenates and Western blot analysis with anti-ENaC antibodies.
Gustavo, Frindt +3 more
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Эпителиальные Na+ -каналы (ENaC): структура, функции и патология
, 2017 АННОТАЦИЯ Выпускной квалификационной работы по основной образовательной программе бакалавриата Иудина Владимира Андреевича Основная образовательная программа «Биология» Направление подготовки: «Биология» Научный руководитель — доцент, к.б.н ...
Иудин Владимир Андреевич +1 more
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Optogenetic Control of PIP2 Interactions Shaping ENaC Activity
, 2022 The activity of the epithelial Na+ Channel (ENaC) is strongly dependent on the membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2). PIP2 binds two distinct cationic clusters within the N termini of β- and γ-ENaC subunits (&beta ...
Mark S. Shapiro +4 more
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, 2017 (A) RT-PCR studies demonstrated the expression of α-, β-, γ-, and δ-ENaC subunit mRNAs in HBO cells. The arrows show the band size. (B) Western blot studies demonstrated the expression of δ-ENaC protein in HBO cells. HEK-293 cells were used as a positive
Shobha Mummalaneni (565983) +12 more
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BMC Research Notes, 2010 Background Epithelial cells are exposed to a variety of mechanical stimuli. Epithelial Na+ channels (ENaC) mediate sodium transport across apical membranes of epithelial cells that line the distal nephron, airway and alveoli, and distal colon.
Ilatovskaya Daria V +2 more
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Select amino acids recover cytokine-altered ENaC function in human bronchial epithelial cells.
PLoS ONEThe airway epithelium plays a pivotal role in regulating mucosal immunity and inflammation. Epithelial barrier function, homeostasis of luminal fluid, and mucociliary clearance are major components of mucosal defense mechanisms.
Anusree Sasidharan +5 more
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