Results 71 to 80 of about 22,476 (217)

Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4.

PLoS ONE, 2015
The membrane-bound serine protease CAP2/Tmprss4 has been previously identified in vitro as a positive regulator of the epithelial sodium channel (ENaC).
Anna Keppner, Ditte Andreasen, Anne-Marie Mérillat, Julie Bapst, Camille Ansermet, Qing Wang, Marc Maillard, Sumedha Malsure, Antoine Nobile, Edith Hummler   +9 more
doaj   +1 more source

Mineralocorticoid receptor stimulation induces urinary storage dysfunction via upregulation of epithelial sodium channel expression in the rat urinary bladder epithelium

Journal of Pharmacological Sciences, 2016
We aimed to evaluate mineralocorticoid receptor (MR) expression in rat bladder and the physiological role of the MR-epithelial sodium channel (ENaC) pathway in controlling bladder function in 10–12-week-old, male Sprague–Dawley rats.
Seiji Yamamoto, Yuji Hotta, Kotomi Maeda, Tomoya Kataoka, Yasuhiro Maeda, Takashi Hamakawa, Shoichi Sasaki, Takahiro Yasui, Kiyofumi Asai, Kazunori Kimura   +9 more
doaj   +1 more source

Reduced Mechanical Tactile Stimulation Under Space Microgravity Affects Synaptic Signaling and Contributes to Neuromuscular Aging in Caenorhabditis elegans

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Microgravity (μG) reduces mechanical tactile stimulation in Caenorhabditis elegans, causing neuromuscular decline, altered gene expression, synaptic defects, and accelerated aging phenotypes. The gentle‐touch mechanoreceptor MEC‐4 mediates μG‐induced body length reduction and extracellular matrix gene downregulation.
Atsushi Higashitani, Je‐Hyun Moon, Jong‐In Hwang, Nahoko Higashitani, Toko Hashizume, Ahmad Aisha Abu, Kazuki Ooizumi, Ibuki Sazuka, Yoshimitsu Hashizume, Masumi Umehara, Alfredo V. Alcantara Jr, Ban‐seok Kim, Timothy Etheridge, Nathaniel J. Szewczyk, Takaaki Abe, Jin I. Lee, Akira Higashibata   +16 more
wiley   +1 more source

ENaC Regulation by Proteases and Shear Stress [PDF]

Current Molecular Pharmacology, 2013
Epithelial Na(+) channels (ENaCs) are comprised of subunits that have large extracellular regions linked to membrane spanning domains where the channel pore and gate reside. A variety of external factors modify channel activity by interacting at sites within extracellular regions that lead to conformational changes that are transmitted to the channel ...
Shujie, Shi, Marcelo D, Carattino, Rebecca P, Hughey, Thomas R, Kleyman   +3 more
openaire   +2 more sources

Biosensors for Biotoxins Detection and Monitoring

Advanced Sensor Research, Volume 5, Issue 6, June 2026.
This review examines state‐of‐the‐art biosensing platforms for biotoxin detection, including antibody‐, aptamer‐, CRISPR‐, nanopore‐, whole cells‐ and MIP‐based sensors. It highlights advances in ultra‐sensitive detection, real‐matrix validation in food and water, and multiplexed analysis, and discusses how the integration with machine learning ...
Alissa Agerova, Juan Francisco Bada Juarez, Matteo Dal Peraro   +2 more
wiley   +1 more source

The Alternatively Spliced Form “b” of the Epithelial Sodium Channel α Subunit (α ENaC): Any Prior Evidence of its Existence?

Clinical Medicine Insights: Cardiology, 2010
The epithelial sodium channel (ENaC) is critical in maintaining sodium balance across aldosterone-responsive epithelia. ENaC is a combined channel formed of three subunits (αβγ) with α ENaC subunit being the most critical for channel functionality.
Marlene F. Shehata
doaj  

Epithelial Na+ Channel: Reciprocal Control by COMMD10 and Nedd4-2

Frontiers in Physiology, 2018
Optimal function of the epithelial sodium channel (ENaC) in the distal nephron is key to the kidney’s long-term control of salt homeostasis and blood pressure.
Adam W. Ware, Tanya T. Cheung, Sahib Rasulov, Ezra Burstein, Fiona J. McDonald   +4 more
doaj   +1 more source

Extracellular Vesicles as Drivers of Lung Endothelial Dysfunction in ARDS: Mechanisms and Therapeutic Opportunities

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
This review summarizes how extracellular vesicles from diverse pulmonary and extrapulmonary sources contribute to endothelial dysfunction in ARDS and evaluates emerging endothelial‐targeted therapies for their potential to mitigate EV‐mediated pathogenic mechanisms.
Mohammed Yaman Al Matni, Patrick Belvitch, Steven M. Dudek, Eleftheria Letsiou   +3 more
wiley   +1 more source

Regulation of ENaC by the Cytoskeleton

The FASEB Journal, 2010
The cytoskeleton is increasingly being recognized for its role in regulating either directly or indirectly membrane organization and signaling pathways. The role the cytoskeleton plays in regulating Epithelial Sodium Channel (ENaC) function, and the mechanisms involved, remain unclear.
Matthew S Reifenberger, B.J Duke, Ling Yu, Douglas Eaton   +3 more
openaire   +1 more source

Increased renal α-epithelial sodium channel (ENAC) protein and increased ENAC activity in normal pregnancy

, 2010
Pregnancy-mediated sodium (Na) retention is required to provide an increase in plasma volume for the growing fetus. The mechanisms responsible for this Na retention are not clear.
Zheng Zhang, Shyama M. E. Masilamani, Geoffrey Ecker, Crystal West   +3 more
core   +1 more source