Results 61 to 70 of about 22,476 (217)

A novel in-house built printed circuit board-ceria based electrochemical device for rapid detection of Epithelial Sodium Channel (ENaC), a hypertension biomarker

Sensors and Actuators Reports
The Epithelial Sodium Channel (ENaC) is a protein that plays a role in the cellular intake of salt and is known as one of the biomarkers for hypertension in the human body. Higher concentrations of sodium lead to increased activity of the ENaC protein in
Riyanto Setiyono, Muhammad Ihda H.L. Zein, Pamungkas Daud, Anni Anggraeni, Yeni Wahyuni Hartati, Husein Hernandi Bahti   +5 more
doaj   +1 more source

Hydrogen sulfide prevents hydrogen peroxide-induced activation of epithelial sodium channel through a PTEN/PI(3,4,5)P3 dependent pathway. [PDF]

PLoS ONE, 2013
Sodium reabsorption through the epithelial sodium channel (ENaC) at the distal segment of the kidney plays an important role in salt-sensitive hypertension.
Jianing Zhang, Shuo Chen, Huibin Liu, Bingkun Zhang, Ying Zhao, Ke Ma, Dan Zhao, Qiushi Wang, Heping Ma, Zhiren Zhang   +9 more
doaj   +1 more source

COVID-19 and Liquid Homeostasis in the Lung—A Perspective through the Epithelial Sodium Channel (ENaC) Lens

Cells, 2022
Infections with a new corona virus in 2019 lead to the definition of a new disease known as Corona Virus Disease 2019 (COVID-19). The sever cases of COVID-19 and the main cause of death due to virus infection are attributed to respiratory distress.
Emily F. Brown, Tamapuretu Mitaera, Martin Fronius   +2 more
doaj   +1 more source

Sodium–glucose cotransporter 2 inhibitors for hypertension in cardiovascular–kidney–metabolic syndrome

Experimental Physiology, EarlyView.
Abstract The antihypertensive mechanism of sodium–glucose cotransporter 2 (SGLT2) inhibitors has been traditionally attributed to osmotic diuresis. However, emerging evidence reveals multifaceted mechanisms beyond diuresis, including regulation of the renin–angiotensin–aldosterone system, sympathetic nervous system suppression, ion homeostasis ...
Chunxiang Xu, Xingyu Qiu, Nan Xu, Gensheng Zhang, Enyin Lai, Liang Zhao   +5 more
wiley   +1 more source

WNK4 inhibits ENaC activity and reduces γ ENaC subunit expression, but has no effect on β ENaC expression

The FASEB Journal, 2010
Recently, a serine‐threonine protein kinase WNK4 expressed in the distal nephron has been shown to inhibit ENaC activity; however, the mechanism of this inhibition is unclear. We examined the effect of expressing WNK4 on endogenous ENaC in A6 cells.
Ling Yu, Hui Cai, B J Duke, Al‐Khalili Otor, Douglas Eaton   +4 more
openaire   +1 more source

Stimulation of ENaC by Thiasolidinediones [PDF]

Biophysical Journal, 2012
Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor gamma (PPARγ) agonists used to treat type II diabetes. Recent studies have shown that TZDs can cause fluid retention and oedema by increasing sodium reabsorption in the renal collecting duct. Those side effects may be caused by the up-regulation of the epithelial Na+ channel (ENaC)
Renauld, Stéphane, Tremblay, Karine, Chraibi, Ahmed   +2 more
openaire   +1 more source

COMMD10 in epithelial sodium channel (ENaC) trafficking [PDF]

, 2020
The epithelial sodium channel (ENaC), is assembled as a heterotrimer composed of three homologous subunits α or δ, β, and γ and is selectively permeable to Na+ ions.
Rasulov, Sahib
core   +1 more source

The Isolated Thumb Domain of Acid‐Sensing Ion Channels Forms a Minimal Folding Unit Enabling Ligand Binding Studies

Angewandte Chemie, Volume 138, Issue 19, 4 May 2026.
An independently folded thumb domain from acid‐sensing ion channels (ASICs) preserves ligand‐binding and proton‐sensing properties. NMR‐based interaction and pKa analyses uncover how endogenous and exogenous peptides modulate ASICs, providing a simplified model for rational drug discovery targeting proton‐gated ion channels.
Biswa P. Mishra, Ben Cristofori‐Armstrong, Elena Budusan, Mimi Golder, Neville J. Butcher, Junyu Liu, Theo Crawford, Yanni K.‐Y. Chin, Anneka Pereira Schmidt, Xinying Jia, Taylor B. Smallwood, Richard J. Clark, Jan P. Wurm, Lachlan D. Rash, Mehdi Mobli   +14 more
wiley   +2 more sources

The interplay between pulsatility, sympathetic regulation and renal physiology: Implications for left ventricular assist devices

Experimental Physiology, EarlyView.
Abstract Left ventricular assist devices have gained traction both as a bridge therapy and as a destination therapy in the management of heart failure. Many of these devices reinstate blood flow in a continuous manner as opposed to the pulsatile flow present in normal physiology.
Tania Warnakulasuriya, Zaid Bahi, Rohit Ramchandra   +2 more
wiley   +1 more source

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source