Results 81 to 90 of about 22,476 (217)

DataSheet_1_Mambalgin-2 Inhibits Lung Adenocarcinoma Growth and Migration by Selective Interaction With ASIC1/α-ENaC/γ-ENaC Heterotrimer.docx

, 2022
Lung cancer is one of the most common cancer types in the world. Despite existing treatment strategies, overall patient survival remains low and new targeted therapies are required.
Mikhail A. Shulepko (7341491), Ekaterina N. Lyukmanova (2265559), Vladislav I. Chubinskiy-Nadezhdin (12966170), Olga V. Shlepova (11429458), Anastasia V. Sudarikova (12966167), Maxim L. Bychkov (11429455), Dmitrii S. Kulbatskii (7341485), Sergey G. Koshelev (11429467), Mikhail P. Kirpichnikov (472252)   +8 more
core   +1 more source

LEFTYA Activates the Epithelial Na+ Channel (ENaC) in Endometrial Cells via Serum and Glucocorticoid Inducible Kinase SGK1

Cellular Physiology and Biochemistry, 2016
Background: Serum & glucocorticoid inducible kinase (SGK1) regulates several ion channels, including amiloride sensitive epithelial Na+ channel (ENaC).
Madhuri S. Salker, Zohreh Hosseinzadeh, Nour Alowayed, Ni Zeng, Anja T. Umbach, Zoe Webster, Yogesh Singh, Jan J. Brosens, Florian Lang   +8 more
doaj   +1 more source

The CFTR and ENaC debate: how important is ENaC in CF lung disease?

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2012
Cystic fibrosis (CF) is caused by the loss of the cystic fibrosis transmembrane conductance regulator (CFTR) function and results in a respiratory phenotype that is characterized by dehydrated mucus and bacterial infections that affect CF patients throughout their lives.
James F, Collawn, Ahmed, Lazrak, Zsuzsa, Bebok, Sadis, Matalon   +3 more
openaire   +3 more sources

Activation of TRPV1 by Capsaicin Regulates ENaC

, 2018
ENaC is a constitutively open heterotrimeric channel which regulates Na+ transport in tight epithelia of the kidney, lungs, colon and anterior tongue containing fungiform taste buds. The amiloride-sensitive ENaC is comprised of aβg subunits.
Saffran, Alexander
core   +1 more source

Epithelial Sodium Channel-α Mediates the Protective Effect of the TNF-Derived TIP Peptide in Pneumolysin-Induced Endothelial Barrier Dysfunction

Frontiers in Immunology, 2017
BackgroundStreptococcus pneumoniae is a major etiologic agent of bacterial pneumonia. Autolysis and antibiotic-mediated lysis of pneumococci induce release of the pore-forming toxin, pneumolysin (PLY), their major virulence factor, which is a prominent ...
Istvan Czikora, Abdel A. Alli, Abdel A. Alli, Supriya Sridhar, Michael A. Matthay, Helena Pillich, Martina Hudel, Besim Berisha, Boris Gorshkov, Maritza J. Romero, Maritza J. Romero, Joyce Gonzales, Guangyu Wu, Yuqing Huo, Yuqing Huo, Yunchao Su, Alexander D. Verin, Alexander D. Verin, David Fulton, David Fulton, Trinad Chakraborty, Douglas C. Eaton, Rudolf Lucas, Rudolf Lucas, Rudolf Lucas   +24 more
doaj   +1 more source

Proteolytic Activation of the Epithelial Sodium Channel in Nephrotic Syndrome by Proteasuria: Concept and Therapeutic Potential

Turkish Journal of Nephrology, 2020
The epithelial sodium channel (ENaC) is expressed in the aldosterone-sensitive distal nephron, and it determines the final urinary sodium concentration.
Ferruh Artunç
doaj   +1 more source

Lock, relax, load, and shoot: a molecular perspective on Nedd4 regulation

The FEBS Journal, Volume 293, Issue 11, Page 3097-3110, June 2026.
Structural basis of inactive and active states of the Nedd4 HECT E3 ligase subfamily, following a ‘lock, relax, load, and shoot’ mechanism. In the locked, autoinhibited state, intramolecular domain interactions restrain the HECT domain. Relaxation releases these restraints, allowing loading of ubiquitin onto the catalytic cysteine, followed by the ...
Masa Janosev, Tomas Obsil, Veronika Obsilova   +2 more
wiley   +1 more source

Impact of inorganic nitrate on renal sodium excretion during saline loading in healthy adults; secondary endpoints from a randomized crossover trial

Physiological Reports, Volume 14, Issue 11, June 2026.
Abstract Inorganic nitrate may lower blood pressure (BP) and enhance natriuresis through nitric oxide (NO) mediated mechanisms. Studies have found inconsistent effects of NO on sodium excretion. Nitric oxide synthase (NOS) inhibition suggests increased NO promotes natriuresis, whereas inorganic nitrate studies remain inconclusive.
A. M. Østergaard, J. B. Rosenbæk, J. A. Ejlersen, F. H. Mose, J. N. Bech, M. H. Vrist   +5 more
wiley   +1 more source

Hypercapnia Impairs ENaC Cell Surface Stability by Promoting Phosphorylation, Polyubiquitination and Endocytosis of β-ENaC in a Human Alveolar Epithelial Cell Line

Frontiers in Immunology, 2017
Acute lung injury is associated with formation of pulmonary edema leading to impaired gas exchange. Patients with acute respiratory distress syndrome (ARDS) require mechanical ventilation to improve oxygenation; however, the use of relatively low tidal ...
Paulina Gwoździńska, Benno A. Buchbinder, Konstantin Mayer, Susanne Herold, Rory E. Morty, Rory E. Morty, Werner Seeger, Werner Seeger, István Vadász   +8 more
doaj   +1 more source

Preferential renal tubular injury and increased renal sympathetic activity occur during the early stages of DOCA‐salt hypertension in male rats

Physiological Reports, Volume 14, Issue 11, June 2026.
Evaluation of cardiovascular parameters and renal mediators during the development of arterial hypertension in male DOCA‐Salt rats. Abstract Although renal dysfunction is present in arterial hypertension, the mechanisms underlying renal glomerular and tubular alterations remain incompletely understood.
Edina Da Luz Abreu, Rafael S. Carvalhal, Ana Caroline Marreiros, Stephanie F. Gerolin, Laura Barroso F. Oliveira, Maria Eduarda Abreu‐Cunha, Diogo B. Peruchetti, Cristiane D. Gil, Cássia T. Bergamaschi, Ruy R. Campos   +9 more
wiley   +1 more source