Results 51 to 60 of about 34,637 (221)

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Organization of the ENaC-regulatory machinery [PDF]

Critical Reviews in Biochemistry and Molecular Biology, 2012
The control of fluid and electrolyte homeostasis in vertebrates requires the integration of a diverse set of signaling inputs, which control epithelial Na(+) transport, the principal ionic component of extracellular fluid. The key site of regulation is a segment of the kidney tubules, frequently termed the aldosterone-sensitive distal nephron, wherein ...
Rama, Soundararajan, Ming, Lu, David, Pearce   +2 more
openaire   +2 more sources

Biphasic regulation of CFTR expression by ENaC in epithelial cells: The involvement of Ca2+-modulated cAMP production

Frontiers in Cell and Developmental Biology, 2022
The regulatory interaction between two typical epithelial ion channels, cystic fibrosis transmembrane conductance regulator (CFTR) and the epithelial sodium channel (ENaC), for epithelial homeostasis has been noted, although the underlying mechanisms ...
Fulei Wuchu, Xiyang Ma, Yanting Que, Junjiang Chen, Junjiang Chen, Ye Chun Ruan, Ye Chun Ruan   +6 more
doaj   +1 more source

Functional expression of TRPV4 channels in human collecting duct cells: implications for secondary hypertension in diabetic nephropathy [PDF]

, 2012
Background. The Vanilloid subfamily of transient receptor potential (TRPV) ion channels has been widely implicated in detecting osmotic and mechanical stress.
Bland, Rosemary, Hills, Claire E., Squires, Paul E.   +2 more
core   +3 more sources

The β integrin modulates serotonin sensitivity via NPxY motifs to regulate egg laying and mechanosensation behaviors in Caenorhabditis elegans

Developmental Dynamics, EarlyView.
Abstract Background Integrin is an αβ heterodimeric receptor to the extracellular matrix; its binding to the matrix recruits focal adhesions to two NPxY motifs, the tyrosine phosphorylation sites in the cytoplasmic domain. Studies found that replacing tyrosines (Y) with phenylalanines (F) in the motif of β1 integrin displayed little developmental or ...
Josh Haram Bumm, Daniel Dogeon Lee, Zhongqiang Qiu, Angela Haeun Choi, Meghana Kolluri, Michael J. Olsen, Lianzijun Wang, Myeongwoo Lee   +7 more
wiley   +1 more source

Pro-Secretory Activity and Pharmacology in Rabbits of an Aminophenyl-1,3,5-Triazine CFTR Activator for Dry Eye Disorders. [PDF]

, 2017
PurposePharmacological activation of ocular surface cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels is a potential pro-secretory approach to treat dry eye disorders.
Felix, Christian M, Lee, Sujin, Levin, Marc H, Verkman, Alan S   +3 more
core   +2 more sources

Biomarkers of lung congestion and injury in acute heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 781-789, April 2025.
Abstract Acute heart failure (AHF) classification and management are primarily based on lung congestion and/or hypoperfusion. The quantification of the vascular and tissue lung damage is not standard practice though biomarkers of lung injury may play a relevant role in this context.
Marco Guazzi, Gabriele Novello, Francesca Bursi, Anna Caretti, Noemi Furlotti, Ross Arena, Paola Argiento, Julio Núñez, Antoni Bayes‐Genis, Marco Metra   +9 more
wiley   +1 more source

WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination

American Journal of Physiology-Renal Physiology, 2013
A serine-threonine protein kinase, WNK4, reduces Na+reabsorption and K+secretion in the distal convoluted tubule by reducing trafficking of the thiazide-sensitive Na-Cl cotransporter to and enhancing renal outer medullary potassium channel retrieval from the apical membrane.
Ling, Yu, Hui, Cai, Qian, Yue, Abdel A, Alli, DeXuan, Wang, Otor, Al-Khalili, Hui-Fang, Bao, Douglas C, Eaton   +7 more
openaire   +3 more sources

The role of the epithelial Na+ channel (ENaC) in high AVP but low aldosterone states [PDF]

, 2012
Due to the abundance of seminal discoveries establishing a strong causal relation between changes in aldosterone signaling, the activity of the epithelial Na(+) channel (ENaC) and blood pressure, the role of ENaC in health and disease is understood ...
James D. Stockand
core   +2 more sources

A Parallelized 3D Geomechanical Solver for Fluid‐Induced Fault Slip in Poroelastic Media

International Journal for Numerical and Analytical Methods in Geomechanics, EarlyView.
ABSTRACT We present a fully implicit formulation of coupled fluid flow and geomechanics for fluid injection/withdrawal in fractured reservoirs in the context of CO2$\textrm {CO}_2$ storage. Utilizing a Galerkin finite‐element approach, both flow and poroelasticity equations are discretized on a shared three‐dimensional mesh.
Emil Rinatovich Gallyamov, Guillaume Anciaux, Nicolas Richart, Jean‐François Molinari, Brice Lecampion   +4 more
wiley   +1 more source