Advanced Science, EarlyView.We have developed a Pd‐catalyzed oxidative cyclopropanation of 1,n‐enynes employing cyclic diacyl peroxides as bifunctional reagents that serve as both tether‐tunable oxidants and spatially controlled dicarboxylate anions. ABSTRACT Bicyclo[n.1.0]alkanes are highly valuable scaffolds in drug discovery and synthetic chemistry.
Ting Yuan, Lei Shi
wiley +1 more source
Chiral symmetry breaking and information accumulation in pre-biological protocell evolution
Scientific ReportsWe study a linear evolutionary model based on the two-dimensional distribution of protocells by total enantiomeric excess and the amount of stored information, which they can pass from generation to generation, and without any mutual inhibition.
Konstantin K. Konstantinov +1 more
doaj +1 more source
Organocatalytic stereodivergent synthesis of β,β-disubstituted-α-aminoacids [PDF]
, 2017 In this work, we present an organocatalytic stereodivergent synthesis of β,β-disubstituted-α-aminoacids using arylidene azlactones as starting materials.
Martinelli, Ada
core
Rational design of a (S)-selective-transaminase for asymmetric synthesis of (1S)-1-(1,1′-biphenyl-2-yl)ethanamine [PDF]
, 2016 Amine transaminases offer an environmentally sustainable synthesis route for the production of pure chiral amines. However, their catalytic efficiency toward bulky ketone substrates is greatly limited by steric hindrance and therefore presents a great ...
Allen, Christopher C.R. +12 more
core +3 more sources
Advanced Science, EarlyView.Difluoromethyl (CF2H) group, the bioisostere of hydroxyl thiol methyl or amide is privileged in medicinal chemistry due to hydrogen‐binding ability and lipophilic, metabolically stable, and chemical inert nature. However, enatioseleceive CF2H introduction remains challenging.
Peng Liu +9 more
wiley +1 more source
Highly Efficient Lipase-Catalyzed Kinetic Resolution of Chiral Amines
CHIMIA, 1994 The lipase Candida antarctica catalyzes the enantioselective acetylation of chiral primary amines, kinetic resolution leading to an enantiomeric excess (ee) of 90–98%.
Manfred T. Reetz, Claus Dreisbach
doaj +2 more sources
Stochastic Approach to Enantiomeric Excess Amplification and Chiral Symmetry Breaking
, 2006 Stochastic aspects of chemical reaction models related to the Soai reactions as well as to the homochirality in life are studied analytically and numerically by the use of the master equation and random walk model. For systems with a recycling process, a
Blackmond D. G. +29 more
core +1 more source
Application of Chiral Lanthanide-induced Shift Reagents to Optically Active Cations: the Use of Tris[3-(trifluoromethylhydroxymethylene)-( + )-camphorato]europium(III) to Determine the Enantiomeric Purity of Tris(phenanthroline)ruthenium(II) Dichloride [PDF]
, 1984 In non-polar solvents, chiral europium complexes provide attractive n. m. r. shift reagents to resolve spectra of optically active cations, and, in particular, for tris(phenanthroline)ruthenium dichloride,^1H n. m. r. shift differences of up to 0.7 p.p.m.
Barton, Jacqueline K., Nowick, James S.
core +1 more source
Determining enantiomeric excess using indicator-displacement assays
, 2008 The invention includes an enantioselective indicator-displacement assay useful to determine enantiomeric excess (ee) enantiomeric samples calorimetrically. Determination may be by inspection of color with the naked eye, spectrographic measurement, or mathematical calculation. Concentration may also be determined.
Eric V. Anslyn +2 more
openaire +3 more sources
Modification of chiral dimethyl tartrate through transesterification : immobilisation on POSS and enantioselectivity reversion in Sharpless asymmetric epoxidation [PDF]
, 2010 Modification of dimethyl tartrate has been investigated through transesterification with aminoalcohols to provide reactive functionalities for the covalent bonding of chiral tartrate to polyhedral oligomeric silsesquioxanes.
García, Rafael A. +4 more
core +1 more source