Results 61 to 70 of about 691,764 (293)

Atroposelective Suzuki–Miyaura Coupling to Form 2‐Amino‐2′‐Hydroxybiphenyls Enabled by sRuPhos

Angewandte Chemie, EarlyView.
We report a new chiral phosphine ligand, sRuPhos, which permits the highly enantioselective Suzuki–Miyaura coupling of ortho‐aniline and ortho‐phenol building blocks. This results in 2‐amino‐2′‐hydroxybiphenyls with very high enantiomeric excesses, products that will have application in pharmaceutical synthesis and ligand design for catalysis ...
Hamzah Sharif, Luke A. McCall, Matthew G. Sanders, Robert J. Phipps   +3 more
wiley   +2 more sources

(Poly)Borylated Species as Modern Reactive Groups toward Unusual Synthetic Applications

Angewandte Chemie, EarlyView.
In this review, we spotlight recent breakthroughs in α‐polyboron‐substituted carbon‐centered intermediates (carbanion, carbocation, radical, and carbene) and polyborylated alkenes. By bridging fundamental reactivity with the application potential of these extraordinary species, we hope this review will serve as a roadmap for harnessing these unique ...
Nadim Eghbarieh, Nicole Hanania, Pinaki Nad, Tipu Alam, Tamir Kish, Ahmad Masarwa   +5 more
wiley   +2 more sources

Towards Chemoenzymatic Syntheses of Both Enantiomers of Phosphoemeriamine

Molecules
An enzyme-promoted addition of nitromethane to the appropriate phosphorylated imine (aza-Henry reaction) intended to be used in the synthesis of the title phosphoemeriamine, a phospha-analog of emeriamine (aminocarnitine), failed due to the ...
Piotr Kiełbasiński, Małgorzata Kwiatkowska, Piotr Łyżwa, Marian Mikołajczyk   +3 more
doaj   +1 more source

Chiral Polymerization in Open Systems From Chiral-Selective Reaction Rates

, 2012
We investigate the possibility that prebiotic homochirality can be achieved exclusively through chiral-selective reaction rate parameters without any other explicit mechanism for chiral bias.
A Bakasov, A Salam, Bradley J. Nelson, C Chyba, C McKay, D Fitz, DG Fraser, DK Kondepudi, DP Glavin, F Frank, FHC Crick, J Bailey, JAD Wattis, JAD Wattis, JB Corliss, JD Dunitz, JR Cronin, LD Landau, LE Orgel, M Gleiser, M Gleiser, MA Zuilen van, Marcelo Gleiser, PC Joshi, PCW Davies, PCW Davies, PGH Sandars, R Gomes, R Hazen, R Plasson, SA Benner, Sara Imari Walker, SJ Mojzsis, W Gilbert, WA Bonner, Y Saito, Y Yamagata, Z Martins   +37 more
core   +1 more source

Electrosynthesis of Bioactive Chemicals, From Ions to Pharmaceuticals

Advanced Functional Materials, EarlyView.
This review discusses recent advances in electrosynthesis for biomedical and pharmaceutical applications. It covers key electrochemical materials enabling precise delivery of ions and small molecules for cellular modulation and disease treatment, alongside catalytic systems for pharmaceutical synthesis.
Gwangbin Lee, Sojin Kim, Myeongeun Lee, Kyoungsuk Jin, Jimin Park   +4 more
wiley   +1 more source

Stereospecific Transition-Metal-Free Alkylation of Chiral Non-Racemic Secondary Tosylates with Cyanohydrins: Convenient Access to Enantiomerically Enriched α-Tertiary Ketones. [PDF]

Angew Chem Int Ed Engl
A stereospecific, transition‐metal‐free SN2 alkylation of cyanohydrins with chiral non‐racemic secondary tosylates is reported, providing efficient access to enantioenriched α‐tertiary ketones. The method exhibits broad substrate scope, operational simplicity, and excellent stereospecificity, including stereoconvergent reactions of E/Z mixtures of ...
Ma J, Li H, Majhi J, Evans PA.
europepmc   +3 more sources

Dual Circularly Polarized Luminescence from Chiral Boron‐Embedded Polycyclic Aromatic Hydrocarbons

Angewandte Chemie, EarlyView.
Boron‐embedded polycyclic aromatic hydrocarbons featuring an asymmetric boron center coordinated by a proximal P═O group were synthesized. Anthracene‐fused boracyclic derivatives show dual circularly polarized luminescence (CPL) arising from excited‐state P═O⋯B dissociation, which converts point chirality into C−B axial chirality.
Tatsuya Mori, Yoshiharu Sano, Tomoyuki Ikai, Yuuya Kawasaki, Katsuhiko Tomooka, Takahiro Sasamori, Shigehiro Yamaguchi   +6 more
wiley   +2 more sources

Assignment-free chirality detection in unknown samples via microwave three-wave mixing

Communications Chemistry, 2022
Identification of chiral molecules in multi-component mixtures of unknown compositions remains a challenge. Here, the authors show that microwave three-wave mixing that uses broad-spectrum fields can detect chiral molecules in enantiomeric excess without
Greta Koumarianou, Irene Wang, Lincoln Satterthwaite, David Patterson   +3 more
doaj   +1 more source

Chiral polymerization: symmetry breaking and entropy production in closed systems

, 2011
We solve numerically a kinetic model of chiral polymerization in systems closed to matter and energy flow, paying special emphasis to its ability to amplify the small initial enantiomeric excesses due to the internal and unavoidable statistical ...
Avetisov, Avetisov, Blanco, Blocher, Brandenburg, Brandenburg, Brandenburg, Celia Blanco, Chaikin, Cross, Crusats, David Hochberg, De Greef, Frank, Gleiser, Gleiser, Gleiser, Gleiser, Goldanski, Guijarro, Hitz, Hitz, Hochberg, Illos, Kondepudi, Kondepudi, Kondepudi, Mauksch, Mills, Mislow, Nery, Plasson, Ribó, Ross, Rubinstein, Rubinstein, Saito, Sandars, Scott, Siegel, Stier, Stier, Wattis, Wattis, Weissbuch, Weissbuch   +45 more
core   +1 more source

Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers. [PDF]

, 2017
Occult bacterial infections represent a worldwide health problem. Differentiating active bacterial infection from sterile inflammation can be difficult using current imaging tools. Present clinically viable methodologies either detect morphologic changes
Blecha, Joseph E, Flavell, Robert R, Kwak, Tiffany, Mutch, Christopher A, Neumann, Kiel D, Ohliger, Michael A, Rosenberg, Oren S, Sriram, Renuka, VanBrocklin, Henry F, Villanueva-Meyer, Javier E, Wilson, David M   +10 more
core   +1 more source