Results 251 to 260 of about 48,679 (293)
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Chromatographic separation of enantiomers
Pharmaceutisch Weekblad Scientific Edition, 1988In this paper a review is presented on the chromatographic analysis of enantiomers with special attention to high pressure liquid chromatography. Also, some examples of resolution of racemates by thin layer chromatography and gas chromatography are given.
K G, Feitsma, B F, Drenth
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Synthesis of the enantiomer of nelarabine
Tetrahedron Letters, 2005AbstractFor Abstract see ChemInform Abstract in Full Text.
Karim Herbal +3 more
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Enantiomer specific pharmacokinetics
Pharmacology & Therapeutics, 1990To indicate the extent of differences in the pharmacokinetics of enantiomers with respect to absorption and disposition phenomena. To emphasise the potential benefits of studying enantiospecific pharmacokinetics, that is, kinetics based on the measurement of the time-course of separate isomers rather than of the total, racemic drug ...
G T, Tucker, M S, Lennard
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The Enantiomers: Revolution or Evolution
Current Topics in Medicinal Chemistry, 2001The use of single stereoisomers are gaining popularity in the world of anesthesiology. The reduced costs of production have made these compounds available for clinical application. The majority of drugs used in anesthesiology such as ketamine, isoflurane, etomidate, atracurium, bupivacaine and ropivacaine have an asymmetric carbon, and are still used ...
Ekatodramis G, Borgeat A
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Stochastic Detection of Enantiomers
Journal of the American Chemical Society, 2006The rapid quantification of the enantiomers of small chiral molecules is very important, notably in pharmacology. Here, we show that the enantiomers of drug molecules can be distinguished by stochastic sensing, a single-molecule detection technique.
Xiao-Feng, Kang +3 more
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Resolution of aristeromycin enantiomers
Journal of Medicinal Chemistry, 1985L'activite biologique des analogues carbocycliques de l'adenosine et de l'adenosine monophosphate peut etre attribuee exclusivement a la presence de l'enantiomere(−) dans les melanges ...
P, Herdewijn +3 more
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Ketamine enantiomers and acetylcholinesterase
Biochemical Pharmacology, 1991(-)-ketamine was found to be more potent than (+)-ketamine in all the studied reactions with acetylcholinesterase. In most cases the difference was small but for two rate constants the (-)-form was unique in having effects. Thus, the stereoselectivity of ketamine in this system is the opposite of most other systems studied.
G, Puu, M, Koch, E, Artursson
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Sympathomimetic enantiomers and asthma
Chirality, 1998Airways of asthma patients can become hyperresponsive to airway spasmogens following regular use of isoprenaline or beta 2-selective sympathomimetics. Hyper-reactivity that results from acute exposure of animals to these drugs is pre-empted by vagal section (a procedure which does not influence spasmolytic efficacy of sympathomimetics), is not ...
D A, Handley +3 more
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Selective radiolysis of enantiomers
Radiation and Environmental Biophysics, 1976The gamma-induced decarboxylation of beta-phenylalanine in the solid state is a chain reaction. Both enantiomers and the racemate of beta-phenylalanine-1-14C show different exponential dose-effect curves for the radiation-induced cleavage of 14CO2.
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Mutagenicity of Enantiomers of Penbutolol
Drug and Chemical Toxicology, 1989With a view to examine the effect of chirality and the cause of batch-to-batch variation in the mutagenicity of penbutolol, penbutolol enantiomers - isopenbutolol [R(+)-enantiomer] and penbutolol [S(-)-enantiomer] - and two batches of Betapressin were tested employing the Ames Salmonella tester strain TA98. The mutagenic activity of R(+)-enantiomer was
S S, Hussain +3 more
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