Results 231 to 240 of about 56,768 (286)

Synthesis of the enantiomer of nelarabine

Tetrahedron Letters, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Karim Herbal, John Kitteringham, Martyn Voyle, Andrew J. Whitehead   +3 more
openaire   +1 more source

Chromatographic separation of enantiomers

Pharmaceutisch Weekblad Scientific Edition, 1988
In this paper a review is presented on the chromatographic analysis of enantiomers with special attention to high pressure liquid chromatography. Also, some examples of resolution of racemates by thin layer chromatography and gas chromatography are given.
K G, Feitsma, B F, Drenth
openaire   +2 more sources

Ketamine enantiomers and acetylcholinesterase

Biochemical Pharmacology, 1991
(-)-ketamine was found to be more potent than (+)-ketamine in all the studied reactions with acetylcholinesterase. In most cases the difference was small but for two rate constants the (-)-form was unique in having effects. Thus, the stereoselectivity of ketamine in this system is the opposite of most other systems studied.
G, Puu, M, Koch, E, Artursson
openaire   +2 more sources

Sympathomimetic enantiomers and asthma

Chirality, 1998
Airways of asthma patients can become hyperresponsive to airway spasmogens following regular use of isoprenaline or beta 2-selective sympathomimetics. Hyper-reactivity that results from acute exposure of animals to these drugs is pre-empted by vagal section (a procedure which does not influence spasmolytic efficacy of sympathomimetics), is not ...
D A, Handley, J R, McCullough, S D, Crowther, J, Morley   +3 more
openaire   +2 more sources

Resolution of aristeromycin enantiomers

Journal of Medicinal Chemistry, 1985
L'activite biologique des analogues carbocycliques de l'adenosine et de l'adenosine monophosphate peut etre attribuee exclusivement a la presence de l'enantiomere(−) dans les melanges ...
P, Herdewijn, J, Balzarini, E, De Clercq, H, Vanderhaeghe   +3 more
openaire   +2 more sources

An introduction to enantiomers in psychopharmacology

Human Psychopharmacology: Clinical and Experimental, 2001
There is growing scientific, clinical, commercial and regulatory recognition that enantiomers offer benefits over racemates in the management of psychiatric diseases as well as in clinical medicine generally. However, relatively few studies consider enantiomers' individual characteristics.
openaire   +2 more sources

Mutagenicity of Enantiomers of Penbutolol

Drug and Chemical Toxicology, 1989
With a view to examine the effect of chirality and the cause of batch-to-batch variation in the mutagenicity of penbutolol, penbutolol enantiomers - isopenbutolol [R(+)-enantiomer] and penbutolol [S(-)-enantiomer] - and two batches of Betapressin were tested employing the Ames Salmonella tester strain TA98. The mutagenic activity of R(+)-enantiomer was
S S, Hussain, H Y, Aboul-Enein, A, al-Dakan, M A, Hannan   +3 more
openaire   +2 more sources

Selective radiolysis of enantiomers

Radiation and Environmental Biophysics, 1976
The gamma-induced decarboxylation of beta-phenylalanine in the solid state is a chain reaction. Both enantiomers and the racemate of beta-phenylalanine-1-14C show different exponential dose-effect curves for the radiation-induced cleavage of 14CO2.
openaire   +2 more sources

CHROMATOGRAPHIC RESOLUTION OF ENANTIOMERS

Chemical Engineering Communications, 1998
Abstract In the pharmaceutical industry, the increasing demand of new single enantiomer products has raised a great interest towards chromatographic separation methods. While analytical applications of high performance liquid chromatography and gas chromatography are well established, the scaling up to preparative applications still needs a better ...
MAZZOTTI, MARCO GIUSEPPE, STORTI, GIUSEPPE, GELOSA, DAVINO, Lorenzetti, L., PEDEFERRI, MARIAPIA, MORBIDELLI, MASSIMO   +5 more
openaire   +3 more sources

Biotransformation of deprenyl enantiomers

European Journal of Drug Metabolism and Pharmacokinetics, 1999
Rats were treated with either (-)- or (+)-deprenyl, and the metabolites extracted from the plasma, liver, kidney and heart homogenates were studied by chiral capillary electrophoresis (CE). Stereoselective dealkylation of both optical isomers with the formation of desmethyldeprenyl (DD), methamphetamine (MA), and amphetamine (A) was found.
E, Szökö, H, Kalász, K, Magyar
openaire   +2 more sources