Results 71 to 80 of about 86,276 (266)
Angewandte Chemie, EarlyView.The second‐generation crystalline sponge method allows structurally diverse molecular guests to crystallize under standardized crystallization conditions. The key is the predominant packing type of cages and anions in crystals. ABSTRACT Crystallization is typically highly sensitive to even minor structural differences in target molecules.
Wei He, Hiroki Takezawa, Makoto Fujita
wiley +2 more sources
Synthesis and structure of trans-1,2,3-tris(3-thenoyl)cyclopropane: erratum [PDF]
, 1994 Misleading statements in the paper by Saba [Acta Cryst.
Saba, Antonio
core +2 more sources
Space Group Modulated Upconversion and Mechanoluminescence in [YbEu] Cocrystal Complexes
Advanced Optical Materials, EarlyView.We report here a space group regulation strategy to optimize both upconversion and mechanoluminescence in cocrystal assemblies, representing the first example of integrating these two properties within a single lanthanide complex material. ABSTRACT Lanthanide complexes exhibiting stimuli‐responsive luminescence, such as upconversion (UC) and ...
Wei Sun +9 more
wiley +1 more source
Photoenzymatic Hydroalkylation Enables Streamlined Access to Aryl Glutarimide Precursors
Angewandte Chemie, EarlyView.We report a photoenzymatic hydroalkylation that enables streamlined, stereocontrolled access to aryl glutarimide precursors relevant to targeted protein degradation. Engineered flavin‐dependent “ene”‐reductases provide broad scope and high enantioselectivity through a distinct electron transfer–enantioselective proton transfer pathway.
Zhi Xu +9 more
wiley +2 more sources
Physiological Reports, 2023 All currently employed pharmaceutical formulations of hydroxychloroquine (HCQ) sulfate are a racemate, consisting of equal parts mixture of two stereoisomers: R(−)HCQ and S(+)HCQ sulfates.
Piotr K. Janicki +3 more
doaj +1 more source
Advanced Science, EarlyView.This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu +7 more
wiley +1 more source
Total Synthesis of the Spirocyclic Bis‐Indole Alkaloid (−)‐Owerreine via a [4+2] Annulation
Angewandte Chemie, EarlyView.The total synthesis of the bis‐indole alkaloid (−)‐owerreine has been accomplished by a diastereoselective [4+2] annulation between an enamine and an α,β−unsaturated indolenine precursor to form the 3‐spirocyclic tetrahydropyridine linkage of the natural product. DFT calculations allow an understanding of the mechanism of the key annulation.
Elisa Coll +4 more
wiley +2 more sources
PharmaceuticalsBackground/Objectives: Diseases associated with inflammatory processes continue to grow steadily throughout the world. Unfortunately, prolonged use of drugs induces adverse effects ranging from hypersensitivity reactions to damage to the digestive system.
Salud Pérez-Gutiérrez +5 more
doaj +1 more source
Chirality in Liquid Crystals: from Microscopic Origins to Macroscopic Structure [PDF]
, 1997 Molecular chirality leads to a wonderful variety of equilibrium structures, from the simple cholesteric phase to the twist-grain-boundary phases, and it is responsible for interesting and technologically important materials like ferroelectric liquid ...
Harris, A. B. +3 more
core +4 more sources
Biolipid Film‐Fused Electrochemiluminescence for Multipurpose In Situ Bioassays
Advanced Science, EarlyView.An ECL‐emissive, membrane‐interactive scaffold was fabricated, and facilely fused with natural and non‐native phospholipids into multifactorial mimicries of cytomembranes and vesicles for in vitro representative membrane‐process probing. Such a biointerface‐based, state‐sensitive ECL paradigm not only pinpointed proximal phenomena, including channeling
Jialiang Chen +9 more
wiley +1 more source