Results 181 to 190 of about 42,802 (288)

Catalytic enantioselective alkene epoxidation using novel spirocyclic N-carbethoxy-azabicyclo[3.2.1]octanones

, 2010
Armstrong, A, Bettati, M, White, AJP
core   +1 more source

Computational redesign and directed evolution of a lanthanide-dependent photoredox enzyme for enantioselective diol cleavage. [PDF]

Chem Sci
Leiss-Maier F, Behringer J, Mustafa G, Heider A, Mühlhofer R, Klein AS, Groll M, Zeymer C.   +7 more
europepmc   +1 more source

Two‐Step Synthesis of a Chiral Fluorinated Alcohol With Silica‐Supported Enzyme RrADH in Batch and Continuous Flow Mode

Chemistry – A European Journal, Volume 32, Issue 16, 25 April 2026.
A two‐step process was transferred from batch to flow mode for the synthesis of (R)‐2‐fluoro‐1‐phenylethanol as a benchmark, consisting of a decarboxylative fluorination in aqueous media, followed by an enantioselective biocatalytic reduction of the prochiral intermediate with RrADH immobilized on silica supraparticles.
Egzon Cermjani, Greta Nölke, Stefano Di Fiore, Christoph Deckers, Doris Hanselmann, Bettina Herbig, Susanne Wintzheimer, Thomas H. Rehm   +7 more
wiley   +1 more source

Total Synthesis of the Spirocyclic Bis‐Indole Alkaloid (−)‐Owerreine via a [4+2] Annulation

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
The total synthesis of the bis‐indole alkaloid (−)‐owerreine has been accomplished by a diastereoselective [4+2] annulation between an enamine and an α,β−unsaturated indolenine precursor to form the 3‐spirocyclic tetrahydropyridine linkage of the natural product. DFT calculations allow an understanding of the mechanism of the key annulation.
Elisa Coll, Vincent Gandon, Cyrille Kouklovsky, Laurent Evanno, Guillaume Vincent   +4 more
wiley   +2 more sources

Stereoselective Chemoenzymatic Synthesis Metaraminol Involving Gold‐Catalysed Alkyne Hydration and Carbonyl Biotransamination

European Journal of Organic Chemistry, Volume 29, Issue 16, 25 April 2026.
A chemoenzymatic synthesis of (1R,2S)‐metaraminol was developed by combining gold(I)‐catalysed alkyne hydration and stereoselective biotransamination in a sequential one‐pot process. Various phenol protection strategies were considered in oxidation‐reduction sequences, providing access to enantiopure propargylic alcohols as starting materials for ...
Lorena Escot, Iván Lavandera, Vicente Gotor‐Fernández   +2 more
wiley   +1 more source

Desymmetrization of Malonic Monoesters and Malonic Acids via Enantioselective Catalytic C(sp³)─H Oxidation. [PDF]

Angew Chem Int Ed Engl
Siakavaras N, Call A, Bietti M, Costas M.   +3 more
europepmc   +1 more source

Enantioselectivity in Transition Metal Catalyzed Propargylic Substitution Reactions: A Theoretical Perspective

Chemistry – A European Journal, Volume 32, Issue 15, 22 April 2026.
Recent theoretical efforts to elucidate the origin of enantioselectivity in transition metal‐catalyzed propargylic substitution reactions are highlighted in this review. ABSTRACT In recent years, asymmetric catalytic propargylic substitution reactions have undergone remarkable development, enabling the construction of chiral carbon centers adjacent to ...
Ken Sakata, Yoshiaki Nishibayashi
wiley   +1 more source

Rh‐Catalyzed Chemodivergent Parallel Kinetic Resolution and Desymmetrization of Enynes and Dienynes with Acrylamides

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
Rh‐catalyzed chemodivergent parallel kinetic resolution of racemic 1,6‐enynes with α‐fluoroacrylamides or mixtures of different acrylamides proceeded via [2+2+2] cycloaddition and C–H alkylation to afford structurally and stereochemically distinct products with high selectivity under mild conditions.
Shintaro Hamada, Julong Jiang, Yu Sato, Takashi Yamazaki, Satoshi Maeda, Ken Tanaka   +5 more
wiley   +2 more sources

Multifunctional Heterocyclic Scaffolds for Hybrid Lewis Acid/Lewis Base Catalysis of Carbon–Carbon Bond Formation [PDF]

, 2016
Benoit, Adam R., Dockendorff, Chris, Huff, Raechel, Lindeman, Sergey, Meyle, Elisia, Porter, Jacob D., Wiedenhoeft, Dennis, Wu, Yibiao, Yeung, Teresa H.W.   +8 more
core   +1 more source

Lipase–V‐MPS Co‐Catalyzed Dynamic Kinetic Resolution of Tertiary Alcohols: Process Intensification Through Catalyst Compartmentalization

European Journal of Organic Chemistry, Volume 29, Issue 15, 22 April 2026.
Dynamic kinetic resolution of tert‐alcohols co‐catalyzed by lipase and V‐MPS4 is reported, enabled by compartmentalization using a polydimethylsiloxane thimble. Physical separation of V‐MPS4 from lipase and Na2CO3 was crucial for preserving its racemization activity.
Satoshi Horino, Karla Wagner, Anke Hummel, Kyohei Kanomata, Harald Gröger, Shuji Akai   +5 more
wiley   +1 more source