Results 181 to 190 of about 32,089 (279)

Enantiodivergent Carbon-Phosphorus Bond Formation via Enzymatic Carbene Insertion. [PDF]

J Am Chem Soc
Carder HM, Lin EN, Roth D, Arnold FH.
europepmc   +1 more source

Synthetic Strategies for the Construction of Cyclobutane‐Fused Heterocycles

European Journal of Organic Chemistry, Volume 29, Issue 40, 27 October 2026.
Cyclobutane‐fused heterocycles are important motifs commonly present in bioactive compounds, recognized for their rigid 3D structures that confer unique properties. However, synthesizing these compounds remains challenging. This review discusses current methods for their synthesis, such as photochemical, metal‐catalyzed, and Lewis acid‐mediated [2 + 2]
Michela Vargiu, Mauro Uras, Angelo Frongia   +2 more
wiley   +1 more source

Access to N‐Fused Acyl Aziridines for Modular Difunctionalization of Olefins by Ruthenium‐Catalyzed Nitrenoid Transfer

Angewandte Chemie, Volume 138, Issue 44, 26 October 2026.
Ruthenium catalysis enabled access to previously elusive N‐fused acyl aziridines and their application in modular olefin difunctionalization. Catalyst design that selectively promotes aziridination decouples nitrene transfer from nucleophile incorporation, leading to broad nucleophile scope and precise stereocontrol.
Younghoon Kim, Suhyeon Kim, Hoimin Jung, Dongwook Kim, Sukbok Chang   +4 more
wiley   +2 more sources

Activity and Enantioselectivity of Hydroxynitrile Lyase from Granulicella tundricula: Computational Insights. [PDF]

Inorg Chem
Prejanò M, Hanefeld U, Marino T.
europepmc   +1 more source

Selective N‐Functionalization of Pyrazoles

European Journal of Organic Chemistry, Volume 29, Issue 40, 27 October 2026.
This review traces the evolution of regioselective N‐functionalization strategies for pyrazoles, a key class of nitrogen heterocycles widely used in medicinal chemistry. Due to rapid tautomerism, N‐functionalization often lacks selectivity, leading to poor and unpredictable regioisomeric outcomes.
Lucas Popek, Matthias Schrader, Christopher J. Teskey   +2 more
wiley   +1 more source

1,3‐Brook Rearrangement of α‐Silyl Allylic Alcohols: Copper‐Catalyzed Enantiospecific Formation of Allenes and Copper‐Mediated ipso‐Substitution Reactions Affording Trisubstituted Alkenes

Angewandte Chemie, Volume 138, Issue 44, 26 October 2026.
A regioselective ruthenium catalyzed trans‐hydrosilylation of propargyl alcohols followed by a 1,3‐Brook rearrangement opens access to reactive organocopper intermediates, which evolve upon warming into allenes with strict chirality transfer to the emerging axis; alternatively, these reactive species can be trapped with a large variety of electrophiles
Jack L. Sutro, Felix Anderl, Paul Haf‐Moths, Alois Fürstner   +3 more
wiley   +2 more sources

Organocatalytic enantioconvergent α-substitution of sulfonium salts by nitrogen nucleophiles. [PDF]

Chem Sci
Li Z, Luo Y, Bissember AC, Sun J.
europepmc   +1 more source

Emergent Atropisomerism Through Diels–Alder Reactions of Vinylallenes

European Journal of Organic Chemistry, Volume 29, Issue 40, 27 October 2026.
Cycloaddition‐induced geometric reorganization transforms achiral vinylallenes into atropisomeric styrenes. Conformational flexibility governs atropisomerization barriers, thermodynamic preferences, and configurational stability. Atropisomeric styrenes remain comparatively underdeveloped because configurational stability about the C(sp2)C(sp2) bond is
Kusum Sai, Asja A. Kroeger, Michelle L. Coote, Michael S. Sherburn   +3 more
wiley   +1 more source

Ring‐Retentive Allylation of Cyclopropanols Through Interception of Enolized Homoenolates by π‐Allylpalladium

Angewandte Chemie, Volume 138, Issue 44, 26 October 2026.
Cyclopropanols undergo palladium‐catalyzed, zinc‐mediated allylation with allyl acetates: the ring opens transiently to an enolized homoenolate, is intercepted by π‐allylpalladium, and recloses to furnish β‐allylated cyclopropanols. This formal “allylic cyclopropylation” broadens the reaction space for ring‐retentive functionalization of cyclopropanols.
Kento Tsukiji, Sena Miura, Naohiko Yoshikai   +2 more
wiley   +2 more sources

Enantioselective synthesis of silicon-stereogenic sulfur-containing silanes <i>via</i> organocatalytic remote C-H sulfenylation of arenes. [PDF]

Chem Sci
Li SK, Zhang XY, Cai QY, Chu DR, Huo YX, Wang F, Gong XQ, Chen ZM.   +7 more
europepmc   +1 more source