Results 171 to 180 of about 32,089 (279)

Recent Advances in Enantioselective Desymmetrization Enabled by Chiral Phosphoric Acid Catalysis. [PDF]

Chirality
Zhang D, Xu B, Yang Y, Zhang D.
europepmc   +1 more source

Multienzyme Cascade Reactions: Compatibility, Cooperativity, and Control

Advanced Synthesis &Catalysis, Volume 368, Issue 21, 3 November 2026.
Multienzyme cascade reactions are sequences of telescoped biotransformations that avoid the isolation of intermediates and offer significant efficiency advantages over traditional multistep routes. This review article highlights recent examples of multienzyme cascades and explores how their success depends on the consideration of compatibility ...
Isabella E. E. Kroschel, Wolfgang Kroutil, Joerg H. Schrittwieser   +2 more
wiley   +1 more source

Strain and Chirality: Catalytic Asymmetric Synthesis of Planar Chiral [2.2]Paracyclophanes

ChemistryEurope, Volume 4, Issue 11, November 2026.
Catalytic asymmetric synthesis is transforming access to planar‐chiral [2.2]paracyclophanes. This Review highlights recent advances in catalytic desymmetrization and asymmetric functionalization, emphasizing how catalyst design and PCP geometry govern reactivity and stereocontrol.
Daniel Alonso, Enrique Gómez‐Bengoa, Rosa López   +2 more
wiley   +1 more source

Unnatural α-amino acid synthesis enabled by nickel-catalysed enantioselective hydrocarbamoylation of enamides via C‒H functionalisation. [PDF]

Nat Commun
Chen X, Kramer S.
europepmc   +1 more source

Target‐Engagement Prediction From Molecular Structure, In Vitro and Animal Data: A Tutorial for Early Assessment of Clinical Drug Exposure and Therapeutic/Adverse Potential Using the ANDROMEDA and PLATO Software on the InSilicoTrials Platform

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 11, November 2026.
ABSTRACT The target‐engagement predictor, implemented within the InSilicoTrials cloud‐based, AI‐powered platform for model‐informed drug discovery and development, enables early exploration of time‐dependent pharmacological responses. Predictions can be generated using inputs ranging from molecular structure to in vitro, animal, and clinical data ...
Niccolò Totis, Fianne Sips, Simona Catozzi, Marc‐Antonio Bisotti, Pauline Bambury, Sofia Stathopoulos, Vincenzo Carbone, Luca Emili, Mario Torchia, Valentina Belgiovine, Fulvio Ciriaco, Orazio Nicolotti, Urban Fagerholm, Candice N. Baker, J. Matthew Mahoney, Daniel Röshammar, on behalf of the CARDIOVERSE Project   +16 more
wiley   +1 more source

Recent advances in metal-free functionalization of 1,4-benzoxazin-2-one scaffolds. [PDF]

RSC Adv
Thakur RK, Keshav K, Patel OPS, Vyas G, Jha AK, Ravi R, Kumar S, Tyagi MK.   +7 more
europepmc   +1 more source

Synthesis of Chiral Gold Nanostructures on Gold‐Coral‐Coated Transparent Conductive Oxide Substrates via [AuCl4]– and Cysteine Interactions for Enhanced Chiral Sensing

Small, Volume 22, Issue 61, 2 November 2026.
We developed hierarchical chiral Au nanostructures on Au coral structures on transparent conductive oxide substrates using only electrochemical methods. By controlling the interaction between [AuCl4]– and cysteine, we successfully tuned the morphology and circular dichroism of the resulting Au nanostructures.
Kenta Nakagawa, Junhe Wang, Tianji Zhang, Yuta Shiga, Olga Guselnikova, Takuya Nakanishi, Yusuke Yamauchi, Toru Asahi   +7 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, Volume 183, Issue 22, Page 6574-6606, November 2026.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Catalytic [6 + 3] cycloaddition for the synthesis of medium-sized ring systems: a critical review. [PDF]

RSC Adv
Archna, Kumar G, Chawla PA, Kumar R, Bhargava G.   +4 more
europepmc   +1 more source

Stereochemical Control in the Matteson Reaction

Chemistry – A European Journal, Volume 32, Issue 40, 27 October 2026.
The Matteson homologation is a highly versatile method for the stereoselective insertion of carbenoids into boronic esters. Through iterative application of the process, complex chiral molecules can be synthesized. The stereoselectivity of the reaction is determined by a chiral diol incorporated in the boronic ester.
Hae Mo Lee, Christoph Hirschhäuser
wiley   +1 more source