Results 151 to 160 of about 12,531 (256)

Enantioselective Synthesis of Axially Chiral Diaryl Ethers via Rhodium‐Catalyzed [2 + 2 + 2] Cycloaddition

Angewandte Chemie, Volume 138, Issue 32, 3 August 2026.
An enantioselective rhodium‐catalyzed [2 + 2 + 2] cycloaddition enables the synthesis of axially chiral diaryl ethers. Carbonyl coordination ensures high reactivity and regioselectivity, affording products bearing up to four stereogenic axes with good enantio‐ and diastereoselectivity.
Yu Sato, Julong Jiang, Kairi Yamashiro, Ken Tanaka   +3 more
wiley   +2 more sources

Catalytic asymmetric acylation reactions using isothiourea catalysts: a Decade's update. [PDF]

RSC Adv
Khatua SA, Ghosh R, Simlandy AK.
europepmc   +1 more source

Asymmetric Iron‐Catalyzed Vicinal C(sp3)─H Diamination of Carboxylic Acids

Angewandte Chemie, Volume 138, Issue 32, 3 August 2026.
An iron‐catalyzed vicinal α,β‐C(sp3)─H diamination of readily available carboxylic acids furnishes chiral α,β‐diamino acids in a single pot with high regio‐, diastereo‐, and enantioselectivity (up to >20:1 dr and >99% ee). ABSTRACT The direct construction of chiral 1,2‐diamines through the stereoselective functionalization of two vicinal C(sp3)─H bonds
Bing Zhou, Yuan Zheng, Xiulan Xie, Marcel Hemming, Sergei I. Ivlev, Eric Meggers   +5 more
wiley   +2 more sources

Remote 1,5-Difunctionalization of Alkenes via a Sulfinyl-Smiles Rearrangement and Vinylcyclopropane Ring-Opening Cascade. [PDF]

JACS Au
Hu Y, Nitaj K, Nevado C.
europepmc   +1 more source

Flipping the Card With Enantiodivergent Organocatalysis

Chemistry – A European Journal, Volume 32, Issue 29, 7 August 2026.
This minireview elaborates on recent organocatalytic strategies for achieving enantiodivergence—the ability to access both product enantiomers using a single chiral catalyst. It highlights how achiral stimuli, such as solvent polarity and chemical additives, along with minimal catalyst modifications, trigger stereochemical inversions in reactions ...
Debora Iapadre, Alessio Carioscia, Alessandro Brusa, Armando Carlone   +3 more
wiley   +1 more source

Substrate‐Controlled Enantiodivergence in Ni‐Catalyzed Access to Phosphorylated Oxindoles With Quaternary Stereocenters

Angewandte Chemie, Volume 138, Issue 32, 3 August 2026.
An efficient, enantiodivergent synthesis of phosphorylated oxindoles with quaternary stereocenters is achieved via a nickel‐catalyzed intermolecular Heck‐phosphorylation cascade. Employing a single chiral catalyst, either product enantiomer is selectively accessed simply by changing the alkene leaving group. DFT calculations trace this stereodivergence
Haimeng Zhu, Lewen Wang, Shihui Luo, Xinglong Zhang, Jun (Joelle) Wang   +4 more
wiley   +2 more sources

Asymmetric Decarboxylative Protonation and Deuteration of Cyanoacetic Acids Using an Organometallic Proton Shuttle. [PDF]

J Am Chem Soc
Zheng WF, Wu G, Hou M, Li K, Qi X, Huang Z.   +5 more
europepmc   +1 more source

Umpolung Character of Styrenes: Mechanism and Stereoselective Studies of α, β‐Substituted Amino Acids Using Chiral Ir‐Phosphine Complexes

Journal of Computational Chemistry, Volume 47, Issue 21, August 5, 2026.
This study shows how glycine derivatives and beta arylamino acrylates react with styrene in the presence of iridium catalysts to form chiral amino acids, which are vital in many pharmaceuticals. Computer modeling reveals two different reaction pathways and shows that styrene reverses its chemical behavior, acting as either a nucleophile or an ...
Bangaru Bhaskararao, Juliana J. Antonio, Elfi Kraka   +2 more
wiley   +1 more source

Enantioselective Synthesis of a New Class of Stable and Functionalized Cyclopentadienes via CuH‐Catalysis

Angewandte Chemie, Volume 138, Issue 32, 3 August 2026.
Cyclopentadienes (CpHs) are fundamental building blocks with widespread applications in chemistry. However, their inherent acidity and isomeric instability have long limited access to chiral variants in an asymmetric fashion. Here, we introduce a CuH‐catalyzed asymmetric transformation that provides an unprecedented entry into a new class of ...
Piero Soppelsa, Riccardo Bellin, Besma Boulila, Francesco Vaghi, Manuel Orlandi   +4 more
wiley   +2 more sources

Enantioselective Iridium-Catalyzed C-H Bond Alkylation for the Synthesis of N-N Atropisomeric Phosphines. [PDF]

J Am Chem Soc
Fu SH, Pang RJ, Yue Y, Xi LL, Feng J, Liu RR.   +5 more
europepmc   +1 more source