Results 151 to 160 of about 42,802 (288)

Emergent Strategies for Catalytic Enantioselective Direct Thiocyanation and Selenocyanation Reactions

SynOpen, 2023
Floris Buttard, Tatiana Besset
doaj   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

The Structure of Carboxyl Methyltransferase Provides Insights Into the Substrate Specificity and Divergent Evolution of Iridoid

Plant Biotechnology Journal, EarlyView.
ABSTRACT Iridoids constitute a prominent class of plant‐specialised metabolites, with carbocyclic iridoids (e.g., geniposide) and secoiridoids (e.g., loganin) diverging early in their biosynthetic pathways. This divergence is marked by substrate‐specific carboxyl methyltransferases—GjGAMT and CrLAMT—that catalyse the decisive methylation step in ...
Li Li, Zhiteng Luo, Zhaoyin He, Jie Tang, Wuke Wei, Ruoting Zhan, Huihao Zhou, Dongming Ma   +7 more
wiley   +1 more source

Functionalized Diaryliodonium Salts with N‐Reactive Amides: Versatile Reactivity for Constructing Benzo‐Fused Nitrogen Heterocycles

Advanced Synthesis &Catalysis, Volume 368, Issue 9, 5 May 2026.
A practical one‐pot strategy for the synthesis of ortho‐amide‐functionalized TMP‐iodonium(III) salts has been developed. These iodonium salts exhibited distinct reactivities toward N‐, O‐, and S‐nucleophiles, facilitating arylocyclization and producing a variety of benzo‐fused heterocycles under mild conditions.
Naoki Miyamoto, Kotaro Kikushima, Arisu Kasai, Yasuyuki Kita, Toshifumi Dohi   +4 more
wiley   +1 more source

Facile Access to N‐Substituted Pyridyl Ligands

Advanced Synthesis &Catalysis, Volume 368, Issue 9, 5 May 2026.
A modular, robust, and versatile Buchwald–Hartwig amination protocol that enables the rapid synthesis of bipyridine, phenanthroline, terpyridine, and pybox ligands bearing dialkylamine, diarylamine, and heteroaromatic N‐substituents. Pyridyl motifs equipped with N‐substituents can be powerful ligands for catalysis, yet their broader adoption is limited
Adam Petrik, Aleksander R. Bena, Haralds Baunis, Riley M. Kelch, Tehshik P. Yoon, Bartholomäus Pieber   +5 more
wiley   +1 more source

Half-Sandwich d⁶-Metal (Co^III, Rh^III, Ir^III, Ru^II)-Catalyzed Enantioselective C–H Activation

SynOpen, 2023
Pu-Fan Qian, Jun-Yi Li, Yi-Bo Zhou, Tao Zhou, Bing-Feng Shi   +4 more
doaj   +1 more source

Catalytic Enantioselective Synthesis of Conformationally Stable C(sp2)−C(sp3) Naphthocoumarin Atropisomers

Advanced Synthesis &Catalysis, Volume 368, Issue 9, 5 May 2026.
The enantioselective synthesis of naphthocoumarin adducts via a tandem organocatalytic 1,4‐addition/decarboxylation delivers excellent control over a newly forged stereocenter and yields configurationally stable synclinal atropisomers. The process features broad substrate scope and scalability, and its structural and mechanistic foundations are ...
M. Chiara Cabua, Davide Moi, Emanuele Cocco, Valentina Onnis, Enrico Podda, David J. Aitken, Armando Carlone, Renzo Luisi, Enrica Tuveri, Drew F. Parsons, Francesco Secci   +10 more
wiley   +1 more source

Enantioselective electrophilic α-fluorination catalyzed by an artificial metalloenzyme. [PDF]

Chem Sci
Yu J, Wang C, Hu W, Wang H, Zhao J, Pan HJ.   +5 more
europepmc   +1 more source

Desymmetrization of Pseudo‐para Diformyl[2.2]Paracyclophane via Brønsted Acid‐Catalyzed Reductive Amination

Advanced Synthesis &Catalysis, Volume 368, Issue 9, 5 May 2026.
A highly stereoselective desymmetrization of pseudo‐para diformyl[2.2]paracyclophanes is developed via chiral Brønsted acid‐catalyzed reductive amination. This protocol provides efficient access to enantiopure planar chiral paracyclophanes with broad substrate scope, excellent enantioselectivity, and versatile postsynthetic functionalization. Access to
Sandip Baban Shinde, Martin Kamlar, Vojtěch Dočekal, Ivana Císařová, Jan Veselý   +4 more
wiley   +1 more source

Enantioselective Synthesis of Spirolactones and Spirolactams Under Low Catalyst Loadings. [PDF]

J Am Chem Soc
Saito T, Navarro A, Davies HML.
europepmc   +1 more source