Results 141 to 150 of about 32,089 (279)

Enantioselective Conjugate Addition of Malononitriles to Enynes: A Stereodivergent Approach to Chiral Allenes

European Journal of Organic Chemistry, EarlyView.
Quinine‐catalyzed enantioselective conjugate addition of malononitrile derivatives to enynes provides trisubstituted chiral allenes in good to excellent yields and high enantiopurities under mild conditions. Broad substrate scope, easy scalability, and versatile post‐synthetic transformations into enantioenriched pyrazoles and furans highlight the ...
Martin Kamlar, Josef Panenka, Ivana Císařová, Jan Veselý   +3 more
wiley   +1 more source

Nucleophilic Reactions of Cyclobutenones and the Related 4,4‐Dichlorocyclobutenone Derivatives

European Journal of Organic Chemistry, EarlyView.
Cyclobutenone derivates and their 4,4‐dichloro counterparts have an uninterrupted attention as useful synthons in the synthesis of complex organic molecules. Their nucleophilic reactions remain underexplored. This review brings attention to these reactions, whose outcome is not straightforward.
Sarah J. Wright, Muhluri H. Mthombeni, Songeziwe Ntsimango   +2 more
wiley   +1 more source

Emergent Strategies for Catalytic Enantioselective Direct Thiocyanation and Selenocyanation Reactions

SynOpen, 2023
Floris Buttard, Tatiana Besset
doaj   +1 more source

Investigation of α‐Silylalcohols as Chiral Umpolung Carbanion Surrogates Through Stereospecific 1,2‐Brook Rearrangement

European Journal of Organic Chemistry, EarlyView.
Deprotonation of chiral α‐silyl secondary alcohols leads to masked polarity‐reversed chiral carbanions through stereospecific 1,2‐Brook rearrangement. In situ trapping with Weinreb amide electrophiles affords α‐hydroxyketones with moderate to excellent enantiospecificity (es).
TyAnn McHenry, Joshua D. Sieber
wiley   +1 more source

Enantioselective Benzylic C-H Insertions with Diazosuccinate Esters. [PDF]

Org Lett
Kamuti NM, Bagale B, Bunge SD, Ndakala AJ, Mighion JD.   +4 more
europepmc   +1 more source

Bromonitroalkanes in Organic Synthesis

European Journal of Organic Chemistry, EarlyView.
α,α‐Bromonitroalkanes (BNAs) exhibit chameleon‐like reactivity, serving as carbene, radical, carbanion, and carbocation synthons. This mini‐review summarizes the different reaction modes and highlights recent developments in thermal and photochemical processes. α,α‐Bromonitroalkanes (BNAs) exhibit chameleon‐like reactivity, serving as carbene, radical,
Magdalena Koch, Oliver Reiser
wiley   +1 more source

Multiplicative Stereocontrol in the Light-Driven Deracemization of Benzylic Nitriles. [PDF]

J Am Chem Soc
Du YE, Hurlburt AS, Wang JY, Yan Q, Knowles RR.   +4 more
europepmc   +1 more source

Axial Chirality Control Through Palladium‐Catalyzed Alkenylation Reactions for the Atroposelective Synthesis of 4‐Arylquinolin‐2‐ones

European Journal of Organic Chemistry, EarlyView.
Palladium(II)‐catalyzed intramolecular C─H alkenylation of cinnamides allows the atroposelective synthesis of axially chiral 4‐arylquinolones, with the chirality being installed by ring formation. DFT studies have shown that the reaction proceeds by prior activation of the alkene and the enantioselectivity is determined during the β‐hydride elimination
Brenda Fundora, Asier Carral‐Menoyo, Mikel Martinez‐Nunes, Sheila Brown, Yeray Ferrero, Yaneris Martinez‐Mendizábal, Nuria Sotomayor, Enrique Gómez‐Bengoa, Esther Lete   +8 more
wiley   +1 more source

Unraveling a Case Where the NAC Approach Fails─MD and QM Modeling of Regioselective cis-Stilbene Oxide Hydrolysis by Engineered Epoxide Hydrolases. [PDF]

J Chem Inf Model
Bombino E, Arabnejad H, Liu B, Jekel PA, Sheng X, Janssen DB, Himo F, Wijma HJ.   +7 more
europepmc   +1 more source

Carbon‐Supported Catalytic Systems Assembled by π–π Interactions

European Journal of Organic Chemistry, EarlyView.
This review explores the noncovalent immobilization of organic and organometallic catalysts on carbonaceous supports through π–π interactions, highlighting its potential to enhance catalyst recovery, recyclability, and the sustainability of organic synthesis.
Chloé Jamalkhan, Léa Ibos, Sarah Bouery, Veronika Myronova, Anaïs Scuiller, Mohamed Mellah, David Kreher, Emmanuelle Schulz, Olivier R. P. David   +8 more
wiley   +1 more source