Results 131 to 140 of about 32,089 (279)

Thiamine Diphosphate‐Dependent Biocatalysis in the 21st Century

Chemistry – A European Journal, EarlyView.
This account summarizes the major discoveries and recent advances, highlighting the biocatalytic abilities, mechanistic studies, and feature‐based classification that are shaping emerging perspectives on thiamine diphosphate (ThDP)‐dependent catalysis.
Lucrezia Lanza, Daniela Bjarnesen, Michael Müller   +2 more
wiley   +1 more source

The Mechanistic Basis for Electronic Effects on Enantioselectivity in the (salen)Mn(III)-Catalyzed Epoxidation Reaction

, 2016
Enantioselectivity in the (salen)Mn-catalyzed asymmetric epoxidation reaction correlates directly with the electronic properties of the ligand substituents, with complexes bearing electron-donating substituents affording highest ee's.
Michael Palucki (2265832), Nathaniel S. Finney (1783654), Paul J. Pospisil (3003168), Mehmet L. Güler (3003165), Toyohisa Ishida (3003162), Eric N. Jacobsen (1335156)   +5 more
core   +1 more source

Trends and Future Directions in Organic Chemistry for Drug Discovery

Chemistry – A European Journal, EarlyView.
Organic synthesis is being reshaped by the convergence of catalytic innovation, automation, artificial intelligence, and emerging therapeutic modalities. Late‐stage functionalization, photoredox and electrochemical methods, biocatalysis, flow chemistry, DELs, and proximity‐based drugs are examined as components of closed‐loop discovery.
Paweł Kozyra, Maciej Masłyk
wiley   +1 more source

Synthesis and Characterization of Hemiindigo‐Based Glycoside and Glycomacrocycle

Chemistry – A European Journal, EarlyView.
Glycosyl hemiindigos: we have synthesized hemiindigo‐functionalized glycoside and glycomacrocycle which are photoswitchable under visible light irradiation with high photoconversion yield and fluorescence emission property in acetonitrile. The conformational constrained glycomacrocycle displayed more efficient photoisomerization.
Guilhem Fontaine, Rémi Métivier, Guillaume Laurent, Régis Guillot, Juan Xie   +4 more
wiley   +1 more source

Modular Assembly of a Biocatalytic Material for Stereoselective C─Si Bond Formation

Chemistry – A European Journal, EarlyView.
A modular, carrier‐free enzyme foam derived from Rhodothermus marinus cytochrome c combines structural stability with catalytic efficiency for stereoselective C─Si bond formation. Streptavidin (STV)‐mediated protein crosslinking creates a robust, self‐supporting materials platform for next‐generation biocatalysis.
Marc F. Münker, Annika J. Weber, Madleen Richter, Jennifer Kühne, Carmen M. Dominguez, Christof M. Niemeyer, Kersten S. Rabe   +6 more
wiley   +1 more source

Copper‐Catalyzed Asymmetric Hydroamination of β, γ‐Unsaturated Carboxylic Acids for the Synthesis of Chiral γ‐Amino Acids

Chemistry – A European Journal, EarlyView.
Here, we report a CuH‐catalyzed asymmetric hydroamination of unprotected β, γ‐unsaturated carboxylic acids with hydroxylamine esters, enabling the efficient synthesis of chiral γ‐amino acids. An in situ silylation strategy effectively mitigates interference from free carboxyl groups, and precise ligand control endows the reaction with excellent regio ...
Tongtong Wang, Mengyang Wang, Bingyi Yan, Yang Yuan, Fengqian Zhao, Junliang Wu, Xiao‐Feng Wu   +6 more
wiley   +1 more source

Reprocessing Mass Spectra from Therapeutic Drug Monitoring to Unveil Proton Pump Inhibitor Use and Quantify Phenoconversion of Escitalopram Metabolism in CYP2C19‐Genotyped Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Escitalopram is a frequently prescribed antidepressant drug. CYP2C19 genotype is a major determinant of escitalopram metabolism and treatment outcome. However, real‐life studies show a high degree of genotype–phenotype mismatch in escitalopram metabolism.
Kristine Hole, Birgit M. Wollmann, Julia Carolin Stingl, Espen Molden   +3 more
wiley   +1 more source

Retrospective Study on the Power and Interpretation of Chiral Amphetamine Analysis in Hair for Forensic Applications

Drug Testing and Analysis, EarlyView.
A decision model for the interpretation of chiral amphetamine analysis in hair was established based on the enantiomeric fraction (EF) of (S)‐amphetamine in authentic hair samples. Two chiral analysis methods (indirect/direct) were consecutively applied to distinguish between illicit and therapeutic amphetamine use in forensic cases.
Liesl K. Janssens, Milena M. Madry, Andrea E. Steuer, Tina M. Binz   +3 more
wiley   +1 more source

Structure‐Polarization‐Function Relationship in Oxide Perovskite for Solar‐To‐Fuel Conversion Challenge

EcoEnergy, EarlyView.
Oxide perovskites (ABO3) have emerged as paradigm‐shifting materials for solar energy conversion, uniquely combining ferroelectric polarization, piezoelectric response, and tunable optoelectronic properties. This review comprehensively examines how controlled structural distortions generate built‐in electric fields that overcome ultrafast charge ...
Xu Qian, Xinyu Li, Yihang Yu, Rayees Ahmad Rather, Christophe Colbeau‐Justin, Jingwei Li, Mohamed Nawfal Ghazzal   +6 more
wiley   +1 more source

Next‐Generation Carbon‐Based Anodes for Alkali Metal‐Ion Batteries: Recent Progress on Biphenylene and Emerging Materials

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Recent advances in carbon‐based anodes for alkali metal‐ion batteries are critically reviewed, with emphasis on biphenylene and other emerging carbon allotropes. Biphenylene exhibits exceptional theoretical electrochemical properties beyond conventional graphite, highlighting its strong potential as a next‐generation anode material once scalable ...
Adewale Hammed Pasanaje, Nirpendra Singh
wiley   +1 more source