Results 161 to 170 of about 32,089 (279)

Modular Synthesis of α‐Quaternary Pyrrolines by Pyridoxal‐Catalyzed Sequential Reactions With Precise Chirality Relay

Transformative Chemistry, EarlyView.
Direct asymmetric α‐C conjugate addition of aminoacetonitrile enabled by carbonyl/iminium double activation, together with subsequent electrophilic functionalization, offers a one‐pot, two‐step modular strategy for synthesizing chiral α‐quaternary pyrrolines with precise chirality relay and high structural diversity.
Xingdie Yang, Pengwei Ji, Liang Liu, Tongyin Chen, Siqi Liu, Wen‐Wen Chen, Baoguo Zhao   +6 more
wiley   +1 more source

Regio- and Enantioselective Functionalization of Gaseous Alkanes via Nickel-Catalyzed Alkene Dicarbofunctionalization. [PDF]

J Am Chem Soc
Barbeira-Arán S, Nair AM, Malga JM, Hu X, Rentería-Gómez Á, Liu Y, Gogoi AR, Gutierrez O, Nevado C, Fañanás-Mastral M.   +9 more
europepmc   +1 more source

Electrochemical Reductive β‐Arylation and Alkenylation of α‐Branched Acroleins by Primary Amine/Nickel Dual Catalysis

Transformative Chemistry, EarlyView.
A synergistic primary amine/nickel catalysis under electrochemical conditions was developed for cathodic β‐arylation and alkenylation of α‐branched acroleins. The reaction proceeds through β‐enaminyl radicals generated by cathodic reduction of an iminium ion allowing smooth coupling with aryl‐ or alkenyl‐Ni(II) species.
Yingdong Duan, Fanzhu Zeng, Qifeng Lin, Sanzhong Luo   +3 more
wiley   +1 more source

Predicting Enantioselectivity of Ruthenium-Catalyzed Ketone Hydrogenation with 3D Structure-Based Deep Learning. [PDF]

J Am Chem Soc
Hadler N, Ramirez E, Avaylon M, Elkin M, Rinehart NI, Mahoney MW, Weber GH, Hoche J, Brandenburg JG, Perciano T, Hartwig JF.   +10 more
europepmc   +1 more source

Oxaziridines: Versatile Reagents in Modern Organic Synthesis

The Chemical Record, EarlyView.
Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida   +2 more
wiley   +1 more source

Catalytic Enantioselective Aziridination of Z-Disubstituted Alkenes with Aspartyl β-Turn-Based Dirhodium(II) Metallopeptides and Assessment of Catalyst Scaffold Versatility. [PDF]

J Am Chem Soc
Pighetti M, Miller BR, Ehrlacher AK, Sigman MS, Miller SJ.   +4 more
europepmc   +1 more source

Metal‐Catalyzed Benzannulation: Recent Advances in Catalyst Design, Mechanistic Insights, and Aromatic Framework Construction

The Chemical Record, EarlyView.
This review offers a contemporary overview of metal‐catalyzed benzannulation (2018–present) encompassing transition, main‐group, post‐transition, and rare‐earth‐metal catalysts. It systematically highlights catalyst design, mechanistic insights, stereo‐ and regioselectivity, and synthetic applications toward aromatic and heteroaromatic scaffolds, while
Sana Jamshaid, Divya Shrestha, Raju S. Thombal, Jeung Gon Kim, Kim Seong Cheol, Yong Rok Lee   +5 more
wiley   +1 more source

Controlling phosphorus(v)-stereogenicity <i>via</i> organocatalytic acylative desymmetrisation of bisphenols. [PDF]

Chem Sci
Platt FM, Prindl MI, Zhou Z, Cordes DB, Panchal H, Smith AD.   +5 more
europepmc   +1 more source

Natural product‐derived TRPM7 channel inhibitors in neurological injury: Mechanisms, pharmacological potential and translational challenges

British Journal of Pharmacology, EarlyView.
Disruption of intracellular ionic homeostasis is a convergent pathological feature across diverse neurological injuries and disorders, including ischaemic and haemorrhagic stroke, hypoxic–ischaemic brain injury, traumatic brain injury, epilepsy and brain tumour.
Xinyang Zhang, Hio Lam Ho, F. David Horgen, Andrea Fleig, Zhong‐Ping Feng, Hong‐Shuo Sun   +5 more
wiley   +1 more source

Taming nitrogen stereogenicity: enantioselectivity control at a reluctant center. [PDF]

Chem Sci
Ramachandran D, Biju AT.
europepmc   +1 more source