Results 221 to 230 of about 12,531 (256)
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Enantioselective Synthesis of Silanol
Journal of the American Chemical Society, 2008An enantioselective nucleophilic substitution reaction of achiral dialkoxysilane has been developed. The reaction proceeds with efficient stereocontrol on the silicon chirality center to give the enantioenriched silyl ether, which can be converted to the silanol without loss of enantiopurity.
Kazunobu, Igawa +3 more
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Enantioselective Synthesis of Silacyclopentanes
Angewandte Chemie, 2016AbstractA variety of functionalized silacyclopentanes were synthesized by highly enantioselective β‐eliminations of silacyclopentene oxides followed by stereospecific transformations. The reaction mechanism of the β‐elimination was elucidated by DFT calculations.
Kazunobu Igawa +3 more
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An Enantioselective Synthesis of Voriconazole
The Journal of Organic Chemistry, 2013A new seven-step sequence to access voriconazole, a clinically used antifungal agent, was developed. The initial catalytic asymmetric cyanosilylation is the key to constructing the consecutive tetra- and trisubstituted stereogenic centers. The fluoropyrimidine unit frequently triggered unexpected side reactions, but careful amendment of the reaction ...
Keiji, Tamura +3 more
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Enantioselective Hydrogenation of Isoquinolines
Angewandte Chemie International Edition, 2013Asymmetric hydrogenation of (hetero)arenes is one of the most straightforward ways to synthesize enantiomerically pure, saturated or partially saturated cyclic molecules. Recent progress has significantly expanded the substrate scope of this reaction.
Dongbing, Zhao, Frank, Glorius
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An enantioselective assay for (±)-modafinil
Journal of Pharmaceutical and Biomedical Analysis, 2001Enantiomers of modafinil, (diphenylmethyl)sulphinyl-2-acetamide, were separated by an amylose tris[(S)-1-phenylethylcarbamate] chiral stationary phase, using acetonitrile: water (25:75 v/v) as mobile phase, with excellent selectivity (alpha=1.4) and resolution factors (R(s)=1.5).
Q B, Cass +3 more
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Catalytic Enantioselective Oxaziridination
Journal of the American Chemical Society, 2011The first catalytic enantioselective synthesis of oxaziridines is presented. The oxidation of aryl and alkyl aldimines with m-CPBA under organocatalytic conditions using cinchona alkaloid-derived catalysts furnished optically active oxaziridines in good yields and high enantioselectivities (up to 94% ee).
Lykke, Lennart +2 more
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An Enantioselective Synthesis of Tarchonanthuslactone
The Journal of Organic Chemistry, 2002An enantioselective synthesis of tarchonanthuslactone has been achieved in eight steps from ethyl sorbate. The asymmetry of the route was introduced via a Sharpless asymmetric dihydroxylation allowing access to either enantiomer. The synthesis utilizes a palladium-catalyzed reduction and a diastereoselective base-catalyzed acetal formation as the key ...
Sarah D, Garaas +2 more
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Angewandte Chemie (International ed. in English)
Even with only a catalytic amount of chiral bis(dihydrooxazole) 1 as external ligand, the rearrangement of benzyl ethers to alcohols [Eq. (1)] proceeds with high enantioselectivity (over 60 % ee). This reaction represents the first example of an enantioselective [1,2] Wittig rearrangement.
, Tomooka, , Yamamoto, , Nakai
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Even with only a catalytic amount of chiral bis(dihydrooxazole) 1 as external ligand, the rearrangement of benzyl ethers to alcohols [Eq. (1)] proceeds with high enantioselectivity (over 60 % ee). This reaction represents the first example of an enantioselective [1,2] Wittig rearrangement.
, Tomooka, , Yamamoto, , Nakai
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Enantioselective Conjugate Borylation
Angewandte Chemie International Edition, 2010Julia A, Schiffner +2 more
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Enantioselectivity of Haloalkane Dehalogenases and its Modulation by Surface Loop Engineering
Angewandte Chemie - International Edition, 2010Zbynĕk Prokop +2 more
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