Diagnosis in Scrapie: Conventional Methods and New Biomarkers [PDF]
Pathogens, 2023 Scrapie, a naturally occurring prion disease affecting goats and sheep, comprises classical and atypical forms, with classical scrapie being the archetype of transmissible spongiform encephalopathies.
Diego Sola +12 more
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Detection of classical BSE prions in asymptomatic cows after inoculation with atypical/Nor98 scrapie [PDF]
Veterinary Research, 2023 The emergence of bovine spongiform encephalopathy (BSE) prions from atypical scrapie has been recently observed upon experimental transmission to rodent and swine models. This study aimed to assess whether the inoculation of atypical scrapie could induce
Marina Betancor +11 more
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Detection of prions in oocytes and ovaries of ewes naturally infected with classical scrapie [PDF]
Veterinary ResearchClassical scrapie is a prion disease that affects goats and sheep and is transmitted mainly horizontally. However, infection can also occur vertically, from mother to offspring, but the exact mechanism is unclear.
Paula A. Marco Lorente +8 more
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Sleep disturbance in clinical and preclinical scrapie-infected sheep measured by polysomnography [PDF]
Veterinary QuarterlyNeurodegenerative diseases are characterised by neuronal loss and abnormal deposition of pathological proteins in the nervous system. Among the most common neurodegenerative diseases are Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s ...
Diego Sola Fraca +5 more
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Novel polymorphisms in the prion protein gene (PRNP) and stability of the resultant prion protein in different horse breeds [PDF]
Veterinary Research, 2023 Prion diseases are fatal neurodegenerative disorders in which the main pathogenic event is the conversion of the cellular prion protein (PrPC) into an abnormal and misfolded isoform known as PrPSc.
Diego Sola +6 more
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Dysregulated microRNAs in blood correlate with central nervous system neuropathology of prion disease [PDF]
Veterinary ResearchThe role of microRNAs (miRNAs) in neurodegenerative diseases has gained significant attention because of their involvement in gene regulation and potential as biomarkers.
Sonia Pérez-Lázaro +6 more
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Heterogeneity of pathological prion protein accumulation in the brain of moose (Alces alces) from Norway, Sweden and Finland with chronic wasting disease [PDF]
Veterinary Research, 2023 Prion diseases are a group of neurodegenerative, transmissible, and fatal disorders that affect several animal species. They are characterized by the conformational conversion of the cellular prion protein (PrPC) into the pathological prion protein ...
Diego Sola +14 more
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SARS-CoV-2 Outbreak on a Spanish Mink Farm: Epidemiological, Molecular, and Pathological Studies [PDF]
Frontiers in Veterinary Science, 2022 Farmed minks have been reported to be highly susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and may represent a risk to humans.
Juan José Badiola +17 more
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Classical BSE prions emerge from asymptomatic pigs challenged with atypical/Nor98 scrapie [PDF]
Scientific Reports, 2021 Pigs are susceptible to infection with the classical bovine spongiform encephalopathy (C-BSE) agent following experimental inoculation, and PrPSc accumulation was detected in porcine tissues after the inoculation of certain scrapie and chronic wasting ...
Belén Marín +12 more
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Encefalopatía hepática: abordaje y tratamiento
Revista de Educaci�n e Investigaci�n en Emergencias, 2023 La encefalopatía hepática se define como una disfunción cerebral causada por insuficiencia hepática o derivación portal-sistémica, que se manifiesta con un amplio espectro de anomalías neurológicas o psiquiátricas que van desde alteraciones subclínicas hasta el coma. Desde la perspectiva fisiopatológica, el amonio sigue siendo el factor principal en la
Jorge E. Lira-Vera +1 more
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