Results 101 to 110 of about 126,056 (280)

Submaximal 2‐day cardiopulmonary exercise testing to assess exercise capacity and post‐exertional symptom exacerbation in people with long COVID

open access: yesExperimental Physiology, EarlyView.
Abstract Long COVID has a complex pathology and a heterogeneous symptom profile that impacts quality of life and functional status. Post‐exertional symptom exacerbation (PESE) affects one‐third of people living with long COVID, but the physiological basis of impaired physical function remains poorly understood. Sixty‐eight people (age (mean ± SD): 50 ± 
Callum Thomas   +19 more
wiley   +1 more source

Persistence of fatigue in the absence of pathophysiological mechanisms in some patients more than 2 years after the original SARS‐CoV‐2 infection

open access: yesExperimental Physiology, EarlyView.
Abstract Following an acute infection with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), a substantial percentage of patients report the persistence of debilitating symptoms, often grouped in a syndrome termed ‘long COVID’. We sought to identify potential pathophysiological mechanisms responsible for the persistence, in some long COVID ...
Giovanni Baldassarre   +10 more
wiley   +1 more source

The glia‐immune network: Astrocytes and oligodendrocytes as microglial co‐ordinators in health and disease

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The glia‐immune network involves the communication(s) of glia via immune signalling pathways. In neuro‐homeostasis these pathways have been shown to modulate key processes such as synaptic pruning and myelination. The dynamics of these processes is critical to CNS function.
Verity F. T. Mitchener   +2 more
wiley   +1 more source

Transcriptional Regulation of Microglial Metabolic and Activation States by P2RY12

open access: yesGlia, Volume 73, Issue 12, Page 2464-2482, December 2025.
Main Points Transcriptionally, P2RY12‐deficient microglia show heightened metabolic activity, iron handling and oxidative stress at baseline. Upon LPS challenge, impaired glutathione antioxidant responses suggest increased vulnerability to ferroptosis. ABSTRACT Microglia are the resident immune cells of the CNS.
Aida Oryza Lopez‐Ortiz   +9 more
wiley   +1 more source

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