Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. [PDF]
, 2006 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is a critical enzyme in the mevalonate pathway that regulates the biosynthesis of cholesterol as well as isoprenoids that mediate the membrane association of certain GTPases.
Dunn, Shannon E +6 more
core +1 more source
Inflammatory Mediators Both Directly and Indirectly Promote Microglial Proliferation
Glia, Volume 74, Issue 5, May 2026.– CSF2, IL3, and TNFɑ directly promote microglial proliferation. – Neuron‐secreted factors suppress microglial proliferation. – IL1 cytokines promote CSF2 release from astrocytes, which promotes microglial proliferation. ABSTRACT Microglia—the predominant immune cell of the central nervous system (CNS)—possess an astounding capacity for proliferation ...
Brady P. Hammond +4 more
wiley +1 more source
CellsProinflammatory T-lymphocytes recruited into the brain and spinal cord mediate multiple sclerosis (MS) and currently there is no cure for MS. IFN-γ-producing Th1 cells induce ascending paralysis in the spinal cord while IL-17-producing Th17 cells mediate
Evaristus C. Mbanefo +7 more
doaj +1 more source
Clinical and Experimental Neuroimmunology, Volume 17, Issue 2, May 2026.ABSTRACT Background Some patients with myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) experience multiple relapses and poor prognoses; however, the factors associated with these outcomes are unclear. This study aimed to identify factors associated with relapse and neurological prognosis in patients with MOGAD.
Masashi Nakamura +4 more
wiley +1 more source
Peroxisome proliferator-activated receptor (PPAR)alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity. [PDF]
, 2007 Peroxisome proliferator-activated receptor (PPAR)alpha is a nuclear receptor that mediates gender differences in lipid metabolism. PPARalpha also functions to control inflammatory responses by repressing the activity of nuclear factor kappaB (NF-kappaB ...
Baranzini, Sergio E +9 more
core
Why Is MS a More Frequent Complication of EBV Infection in Females?
Immunological Reviews, Volume 339, Issue 1, May 2026.ABSTRACT Multiple sclerosis (MS) is a T helper (Th) cell‐mediated disease that targets central nervous system (CNS) white matter. This disease affects three times more females than males. For many years, the etiology of MS was not well understood and the exact nature of the autoimmune reaction was speculative.
Shannon E. Dunn +2 more
wiley +1 more source
Theiler's Murine Encephalomyelitis Virus (TMEV) Subgroup Strain‐Specific Infection in Neural and Non‐Neural Cell Lines [PDF]
, 1999 Masatsugu Obuchi +5 more
openalex +1 more source
Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling
Advanced Science, Volume 13, Issue 19, 2 April 2026.Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang +17 more
wiley +1 more source
Clinical, radiological, therapeutic and prognostic differences between MOG-seropositive and MOG-seronegative pediatric acute disseminated encephalomyelitis patients: a retrospective cohort study [PDF]
, 2023 Xueshan Dong +7 more
openalex +1 more source