Results 71 to 80 of about 167,114,309 (280)

Communication challenges in end-of-life decisions

Swiss Medical Weekly, 2020
With the progress in healthcare over recent decades and a growing life expectancy, discussions and decisions regarding end-of-life issues have become increasingly important. Especially in intensive care and emergency medicine there is a growing need of
Christoph Becker, Katharina Beck, Alessia Vincent, Sabina Hunziker   +3 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Risk factors for potentially avoidable readmissions due to end-of-life care issues

, 2014
BACKGROUND Repeated hospitalizations are frequent toward the end of life, where each admission should be an opportunity to initiate advance-care planning to high-risk patients.
Lipsitz, Stuart, Schnipper, Jeffrey L, Jacques Donzé, Stuart Lipsitz, Jeffrey L. Schnipper, Donzé, Jacques   +5 more
core   +1 more source

European Association for Palliative Care (EAPC) framework for palliative sedation: an ethical discussion

BMC Palliative Care, 2010
Background The aim of this paper is to critically discuss some of the ethically controversial issues regarding continuous deep palliative sedation at the end of life that are addressed in the EAPC recommended framework for the use of sedation in ...
Juth Niklas, Lindblad Anna, Lynöe Niels, Sjöstrand Manne, Helgesson Gert   +4 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discussing Religious and Spiritual Issues at the End of Life: A Practical Guide for Physicians

, 2002
As patients near the end of life, their spiritual and religious concerns may be awakened or intensified. Many physicians, however, feel unskilled and uncomfortable discussing these concerns.
Puchalski, Christina M., Quill, Timothy R., Kates, Laura W., Lo, Bernard, Pantilat, Steven Z., Ruston, Delaney, Cohen, Cynthia B., Rabow, Michael W., Arnold, Robert M., Faber-Langendoen, Kathy, Schreiber, Simeon, Tulsky, James A., Sulmasy, Daniel P.   +12 more
core  

Ethical Issues in the End of Life Care for Cancer Patients in Iran

Iranian Journal of Public Health, 2013
Background: In the recent years, advances in medical technologies for end stage cancer patients’ care have affected the end-of-life decision-making in clinical practice and exposed oncologists to serious ethical dilemmas.
Mina Mobasher, Nouzar Nakhaee, Mamak Tahmasebi, Farzaneh ZaHedi, Bagher Larijani   +4 more
doaj   +2 more sources

End-of-Life Issues in Patients With Left Ventricular Assist Devices. [PDF]

Tex Heart Inst J, 2023
Garcia MAG, Grouls A.
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source