Results 51 to 60 of about 5,625 (121)

Aristolochic Acid Induced Suicidal Erythrocyte Death

Kidney & Blood Pressure Research, 2014
Background/Aims: Aristolochic Acid, a component of Aristolochia plants, has been shown to cause acute kidney injury, renal aristolochic acid nephropathy, Balkan endemic nephropathy, and urothelial carcinoma.
Abaid Malik, Rosi Bissinger, Salvatrice Calabrò, Caterina Faggio, Kashif Jilani, Florian Lang   +5 more
doaj   +1 more source

Metal‐dependent regulated cell death: Molecular architecture and translational frontiers

iMeta, Volume 5, Issue 3, June 2026.
Intracellular metal dyshomeostasis orchestrates distinct regulated cell death programs, including iron‐driven ferroptosis, copper‐mediated cuproptosis, calcicoptosis, newly designated zincoptosis, mnoptosis, and coptosis. This review systematically delineates their molecular architectures—spanning from Sorafenib‐induced lipid peroxidation and ...
Haoliang Hu, Zhe Chen, Yaqi Li, Jiayi Peng, Jiangang Cao, Hong Zhou, Mengqi Wang, Yuejia Du, Hailin Wu, Huiqin Zhao, Shifang Huang, Dianmei Yu, Meiqing Liu, Olga V. Shevchenko, Natalia Yu. Matveeva, Yiyuan Yang, Kerui Huang, Deguan Lv, Junxia Min, Linxi Chen, Fudi Wang   +20 more
wiley   +1 more source

Association of a bitter taste receptor mutation with Balkan Endemic Nephropathy (BEN)

BMC Medical Genetics, 2012
Background Balkan Endemic Nephropathy (BEN) is late-onset kidney disease thought to arise from chronic exposure to aristolochic acid, a phytotoxin that contaminates wheat supplies in rural areas of Eastern Europe.
Wooding Stephen P, Atanasova Srebrena, Gunn Howard C, Staneva Rada, Dimova Invanka, Toncheva Draga   +5 more
doaj   +1 more source

Whole Blood Transcriptomic Analysis of Sickle Cell Trait

European Journal of Haematology, Volume 116, Issue 5, Page 535-544, May 2026.
ABSTRACT Sickle cell trait (SCT) is the heterozygous carrier state for the HBB missense variant which causes sickle cell disease (SCD). SCT has been associated with increased risk of venous thromboembolism and chronic kidney disease as well as alterations in clinical laboratory parameters. To investigate differential gene expression in SCT, we used RNA
Mari Johnson, Yanwei Cai, Ana Gabriela Vasconcelos, Peter Orchard, Paul L. Auer, Guillaume Lettre, Jia Wen, Nora Franceschini, Charles Kooperberg, Wei Sun, Li Hsu, Laura M. Raffield, Alex P. Reiner   +12 more
wiley   +1 more source

Genetics and Genomics in Sickle Cell Disease in Africa

American Journal of Hematology, Volume 101, Issue S1, Page 47-55, April 2026.
ABSTRACT Advanced genomic technologies are revolutionizing our ability to understand complex diseases. Large‐scale population studies are needed to realize the potential of using individual genetic information to personalize treatments for better patient outcomes for chronic non‐communicable diseases, such as sickle cell disease (SCD).
Siana Nkya, Julie Makani, Jonathan M. Flanagan   +2 more
wiley   +1 more source

Balkan Endemic Nephropathy Risk Associates to the hs1.2 Ig Enhancer Polymorphism

European Journal of Inflammation, 2012
Balkan Endemic Nephropathy (BEN) is a kidney degenerative disease with a high incidence in the valleys of the Danube and tributary rivers. Many studies describe it as a multifactorial disease.
D. Frezza, E. Serone, S. Lolli, R. Cianci, P. D'Addabbo, C. Mattioli, V. Giambra, N. Pavlovic, V. Djordjevic, S. Kostic, F. Pandolfi, E. Kostic   +11 more
doaj   +1 more source

Molecular Mechanism of Ochratoxin A Transport in the Kidney

Toxins, 2010
The mycotoxin, ochratoxin A (OTA), is thought to be responsible for Balkan endemic nephropathy. OTA accumulates in several tissues, especially in the kidneys and liver.
Naohiko Anzai, Promsuk Jutabha, Hitoshi Endou   +2 more
doaj   +1 more source

Glomerular Filtration Rate in Examined Population of Bosnian Posavina - Region of Balkan Endemic Nephropathy

Biomolecules & Biomedicine, 2010
Balkan endemic nephropathy (BEN) is chronic tubulointersticial nephritis of unknown aetiology characterized by an insidious onset and gradual progression to end stage renal disease (ESRD).
Mirna Alečković, Enisa Mešić, Senaid Trnačević, Želimir Stipančić, Damir Hamidović, Evlijana Hasanović   +5 more
doaj   +1 more source

Is Increased Susceptibility to Balkan Endemic Nephropathy in Carriers of Common GSTA1 (*A/*B) Polymorphism Linked with the Catalytic Role of GSTA1 in Ochratoxin A Biotransformation? Serbian Case Control Study and In Silico Analysis

Toxins, 2014
Although recent data suggest aristolochic acid as a putative cause of Balkan endemic nephropathy (BEN), evidence also exists in favor of ochratoxin A (OTA) exposure as risk factor for the disease.
Zorica Reljic, Mario Zlatovic, Ana Savic-Radojevic, Tatjana Pekmezovic, Ljubica Djukanovic, Marija Matic, Marija Pljesa-Ercegovac, Jasmina Mimic-Oka, Dejan Opsenica, Tatjana Simic   +9 more
doaj   +1 more source

Exploration of Apoptosis in Histopathologies of Balkan Endemic Nephropathies with Both Urothelial Tumour and Atrophied Kidney

Annals of Urologic Oncology
There seems yet no satisfactory explanation for the mysterious endemic renal disease, known as Balkan endemic nephropathy (BEN), seen across rural parts of several Balkan countries in the last century although some have claimed aristolochic acid as the ...
Peter Mantle, Rohit Upadhyay, Diana Herman, Vecihi Batuman   +3 more
doaj   +1 more source