Results 21 to 30 of about 99 (86)
Metabolism of endocannabinoids
Postępy Higieny i Medycyny Doświadczalnej, 2016 Endocannabinoids belong to a group of ester, ether and amide derivatives of fatty acids, which are endogenous ligands of receptors CB1, CB2, TRPV1 and GPR55 that are included in the endocannabinoid system of the animal organism. The best known endocannabinoids are: N-arachidonylethanolamide called anandamide (AEA) and 2-arachidonoylglycerol (2-AG ...
Michał, Biernacki +1 more
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Cannabis sintético: aspectos toxicológicos, usos clínicos y droga de diseño
Revista de la Facultad de Medicina, 2015 La planta cannabis sativa tiene un largo historial de uso en el transcurso de la humanidad y, desde hace varias décadas, se ha retomado el interés por ella debido a su potencial terapéutico relacionado con diversidad de patologías.
Andrés Felipe Casadiego-Mesa +1 more
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Canadian Journal of Gastroenterology and Hepatology, Volume 25, Issue 7, Page 377-383, 2011., 2011 Many beneficial effects of herbal and synthetic cannabinoids on gut motility and inflammation have been demonstrated, suggesting a vast potential for these compounds in the treatment of gastrointestinal disorders. These effects are based on the so‐called ‘endocannabinoid system’ (ECS), a cooperating network of molecules that regulate the metabolism of ...
Rudolf Schicho, Martin Storr
wiley +1 more source
Endocannabinoid Overload [PDF]
Molecular Pharmacology, 2010 The signaling capacity of endogenous cannabinoids ("endocannabinoids") is tightly regulated by degradative enzymes. This Perspective highlights a research article in this issue (p. 996) in which the authors show that genetic disruption of monoacylglycerol lipase (MAGL), the principal degradative enzyme for the endocannabinoid 2-arachidonoylglycerol (2 ...
Aron H, Lichtman +2 more
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Brazilian Journal of Psychiatry, 2010 OBJETIVO: Este artigo revisa o sistema endocanabinoide e as respectivas estratégias de intervenções farmacológicas. MÉTODO: Realizou-se uma revisão da literatura sobre o sistema endocanabinoide e a sua farmacologia, considerando-se artigos originais ou ...
Viviane M. Saito +2 more
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Pain Research and Management, Volume 6, Issue 2, Page 74-79, 2001., 2001 Cannabinoids have been used to treat pain for many centuries. However, only during the past several decades have rigorous scientific methods been applied to understand the mechanisms of cannabinoid action. Cannabinoid receptors were discovered in the late 1980s and have been found to mediate the effects of cannabinoids on the nervous system.
J Michael Walker +2 more
wiley +1 more source
Endocannabinoids in the Gut [PDF]
Cannabis and Cannabinoid Research, 2016 Cannabis has been used medicinally for centuries to treat a variety of disorders, including those associated with the gastrointestinal tract. The discovery of our bodies' own "cannabis-like molecules" and associated receptors and metabolic machinery - collectively called the endocannabinoid system - enabled investigations into the physiological ...
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The Endocannabinoid System and Spermatogenesis [PDF]
Frontiers in Endocrinology, 2013 Spermatogenesis is a complex process in which male germ cells undergo a mitotic phase followed by meiosis and by a morphogenetic process to form mature spermatozoa. Spermatogenesis is under the control of gonadotropins, steroid hormones and it is modulated by a complex network of autocrine and paracrine factors.
GRIMALDI, PAOLA +2 more
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Endocannabinoids and epilepsy [PDF]
, 2015 The brain endocannabinoid system (ECS) plays an essential role in regulating central physiological processes that underlie learning and memory, anxiety, depression, addiction, appetite and feeding, pain, neuronal excitability and protection. A primary mode through which the ECS functions in the brain is via its regulation of synaptic transmission ...
Robert Blair +2 more
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Endocannabinoids and the Heart [PDF]
Journal of Cardiovascular Pharmacology, 2009 Endocannabinoids, such as anandamide and 2-arachidonoylglycerol, are synthesized from membrane phospholipids in the heart and other cardiovascular tissues. They activate cannabinoid CB1 and CB2 receptors, transient receptor potential V1 (TRPV1), peroxisome proliferator-activated receptors, and perhaps a novel vascular G-protein-coupled receptor ...
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