Results 171 to 180 of about 174,481 (308)

Sulfakinin Signaling Sense Circulating Fructose and Suppresses Food Consumption via Insulin‐Like Peptide in Bactrocera Dorsalis

Advanced Science, EarlyView.
This study discovered a new pathway that tells fruit flies when to stop eating. It found that rising blood sugar (fructose) is detected by a sensor called GR43a. This triggers a chain reaction involving the satiety signal sulfakinin and its receptor, ultimately activating a final satiety signal, ILP5.
Hong‐Fei Li, Bao Dong, Zheng‐Lin Ren, Xue‐Guang Zhu, Quan Lei, Yoonseong Park, Jin‐Jun Wang, Hong‐Bo Jiang   +7 more
wiley   +1 more source

Chemical-Class Submixture Screening Reveals Drivers of Endocrine Disruption in Personalized Human Blood POP Mixtures. [PDF]

Environ Sci Technol
Strand D, Pierozan P, Reis L, Lundgren B, Martin JW, Karlsson O.   +5 more
europepmc   +1 more source

Thyroid-on-a-Chip: An Organoid Platform for In Vitro Assessment of Endocrine Disruption. [PDF]

Adv Healthc Mater, 2023
Carvalho DJ, Kip AM, Romitti M, Nazzari M, Tegel A, Stich M, Krause C, Caiment F, Costagliola S, Moroni L, Giselbrecht S.   +10 more
europepmc   +1 more source

Paving the Way to Elucidate Hg's Role in Tumorigenesis

Advanced Science, EarlyView.
Tumorigenesis can result from diverse environmental carcinogens. Among them, mercury—a lifelong bioaccumulative Group 2B carcinogen—has tumorigenic potential that remains poorly understood due to confounding co‐exposures and limited organ‐specific data.
Shouying Li, Rong Zhong, Zhenyang Yu, Hualing Fu, Jin Chen, Jia Wei, Ningwei Zhao, Le Qu, Tiantian Li, Wenli Tang, Huan Zhong   +10 more
wiley   +1 more source

Insight into the Potential Mechanisms of Endocrine Disruption by Dietary Phytoestrogens in the Context of the Etiopathogenesis of Endometriosis. [PDF]

Int J Mol Sci, 2023
Szukiewicz D.
europepmc   +1 more source

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

PFAS endocrine disruption affecting pubertal development: exposure-response is steeper below median PFAS serum concentrations. [PDF]

Environ Health
van Larebeke N, Voorspoels S, Den Hond E, Leermakers M, Schoeters G.   +4 more
europepmc   +1 more source

Potential Endocrine Disruption of Cyanobacterial Toxins, Microcystins and Cylindrospermopsin: A Review. [PDF]

Toxins (Basel), 2022
Casas-Rodriguez A, Cameán AM, Jos A.
europepmc   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Endocrine disruption to metastasis: How phthalates promote breast carcinogenesis. [PDF]

Ecotoxicol Environ Saf
Tiburcio D, Parsell M, Shapiro H, Adolphe S, Naranjo O, George S, Toborek M.   +6 more
europepmc   +1 more source