Results 51 to 60 of about 675,825 (330)

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

The Cross-Education Phenomenon: Brain and Beyond

Frontiers in Physiology, 2017
Objectives: Unilateral resistance training produces strength gains in the untrained homologous muscle group, an effect termed “cross-education.” The observed strength transfer has traditionally been considered a phenomenon of the nervous system, with few
Ashlee M. Hendy, Séverine Lamon
doaj   +1 more source

Triiodothyronine suppresses humoral immunity but not T-cell-mediated immune response in incubating female eiders (Somateria mollissima)

, 2007
Immunity is believed to share limited resources with other physiological functions and this may partly account for the fitness costs of reproduction. Previous studies have shown that the acquired immunity of female common eiders (Somateria mollissima) is
Ahima, Apanius, Bourgeon, Bourgeon, Bourgeon, Criscuolo, Criscuolo, Deerenberg, Demas, Eraud, Erikstad, Faggioni, Fowles, Gabarrou, Gabrielsen, Gustafsson, Hanssen, Hanssen, Hanssen, Harvey, Korschgen, Lord, Lõhmus, Lõhmus, Martinez-Padilla, Martínez, Matarese, Matarese, McNabb, Merino, Moreno, Norris, Parham, Roitt, Råberg, Saino, Sechman, Sheldon, Smits, Sophie Bourgeon, Stearns, Thierry Raclot, Tomás, Verhulst, Williams, Williamson   +45 more
core   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Oxytocin Modulation in Mindfulness-Based Pain Management for Chronic Pain

Life
In the context of chronic pain management, opioid-based treatments have been heavily relied upon, raising concerns related to addiction and misuse. Non-pharmacological approaches, such as Mindfulness-Based Pain Management, offer alternative strategies ...
Oytun Aygün, Emily Mohr, Colin Duff, Sophie Matthew, Poppy Schoenberg   +4 more
doaj   +1 more source

Endocrine disorders in the background of COVID-19 and postcovid syndrome

Ожирение и метаболизм, 2022
The SARS-CoV-2 virus that caused the 2019 new coronavirus infection (COVID-19) pandemic has posed an unprecedented challenge to the global health system and scientific community. As of this literature review, the infection has claimed more than 6 million
A. V. Klimchuk, V. A. Beloglazov, I. A. Yatskov, Ya. V. Dvoryanchikov   +3 more
doaj   +1 more source

The unsolved case of “bone-impairing analgesics”. The endocrine effects of opioids on bone metabolism [PDF]

, 2015
The current literature describes the possible risks for bone fracture in chronic analgesics users. There are three main hypotheses that could explain the increased risk of fracture associated with central analgesics, such as opioids: 1) the increased ...
COLUZZI, FLAMINIA, MATTIA, Consalvo, Pergolizzi, Joseph, Raffa, Robert B   +3 more
core   +3 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

SchussenAktivplus: reduction of micropollutants and of potentially pathogenic bacteria for further water quality improvement of the river Schussen, a tributary of Lake Constance, Germany [PDF]

, 2013
The project focuses on the efficiency of combined technologies to reduce the release of micropollutants and bacteria into surface waters via sewage treatment plants of different size and via stormwater overflow basins of different types. As a model river
Amler, Klaus, Blaha, Ludek, Gallert, Claudia, Giebner, Sabrina, Güde, Hans, Henneberg, Anja, Hess, Stefanie, Hetzenauer, Harald, Jedele, Klaus, Jung, Ralph-Michael, Kneipp, Sven, Krais, Stefanie, Kuch, Bertram, Köhler, Heinz-R., Lange, Claudia, Löffler, Herbert, Maier, Diana, Metzger, Jörg, Müller, Michael, Oehlmann, Jörg, Osterauer, Raphaela, Peschke, Katharina, Raizner, Jürgen, Rault, Magali, Rey, Peter, Richter, Doreen, Sacher, Frank, Scheurer, Marco, Schneider-Rapp, Jutta, Seifan, Merav, Spieth, Markus, Triebskorn, Rita, Vogel, Hans-Joachim, Weyhmüller, Michael, Winter, Josef, Wurm, Karl   +35 more
core   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source