Results 91 to 100 of about 249,281 (299)

Importance of Endocytosis for the Biological Activity of Cedar Virus Fusion Protein

Cells, 2020
Endocytosis plays a particular role in the proteolytic activation of highly pathogenic henipaviruses Hendra (HeV) and Nipah virus (NiV) fusion (F) protein precursors. These proteins require endocytic uptake from the cell surface to be cleaved by cellular
Kerstin Fischer, Martin H. Groschup, Sandra Diederich   +2 more
doaj   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Dopamine D-3 receptors regulate GABA(A) receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens [PDF]

, 2006
The dopamine D-3 receptor, which is highly enriched in nucleus accumbens (NAc), has been suggested to play an important role in reinforcement and reward.
Kittler, JT, Chen, GJ, Yan, Z, Moss, SJ
core  

SNX9 family mediates βarrestin-independent GPCR endocytosis

Communications Biology
Agonist-stimulated GPCR endocytosis typically occurs via the multi-faceted adaptor proteins known as βarrestins. However, endocytosis of several GPCRs occurs independently of β-arrestins, suggesting an additional mode of GPCR endocytosis, but the ...
Valeria L. Robleto, Ya Zhuo, Joseph M. Crecelius, Sara Benzow, Adriano Marchese   +4 more
doaj   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission [PDF]

, 2017
G protein-coupled receptors (GPCRs) are considered to function primarily at the plasma membrane, where they interact with extracellular ligands and couple to G proteins that transmit intracellular signals.
Pierangelo Geppetti, Halls, Michelle L., Nigel W. Bunnett, Aurelio, Luigi, Christopher J. H. Porter, Jensen, D.D., Wendy L. Imlach, Christie, M.J., Zhijian Cai, Imlach, Wendy L., Lieu, TinaMarie, Daniel P. Poole, Herenbrink, C.K., Porter, C.J.H., Imlach, W.L., MacDonald J. Christie, Nicholas A. Veldhuis, Dane D. Jensen, Canals, M., Poole, Daniel P., Hicks, Gareth A., Jensen, Dane D., Bunnett, Nigel W., Geppetti, P., Halls, M.L., Hicks, G.A., Bunnett, N.W., Yarwood, R.E., Veldhuis, N.A., Veldhuis, Nicholas A., Michelle L. Halls, Geppetti, Pierangelo, Christie, MacDonald J., McLean, Peter, Porter, Christopher J H, Carmen Klein Herenbrink, Cai, Zhijian, TinaMarie Lieu, Meritxell Canals, Yarwood, Rebecca E., McLean, P., Poole, D.P., Canals, Meritxell, Aurelio, L., Gareth A. Hicks, Luigi Aurelio, Herenbrink, Carmen Klein, Rebecca E. Yarwood, Lieu, T., Peter McLean   +49 more
core   +1 more source

Single Event Resolution of Plant Plasma Membrane Protein Endocytosis by TIRF Microscopy

Frontiers in Plant Science, 2017
Endocytosis is a key process in the internalization of extracellular materials and plasma membrane proteins, such as receptors and transporters, thereby controlling many aspects of cell signaling and cellular homeostasis.
Grégory Vert, Alexander Johnson
doaj   +1 more source

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

PhotonSABER: new tool shedding light on endocytosis and learning mechanisms in vivo

Communicative & Integrative Biology, 2019
In the central nervous system, activity-dependent endocytosis of postsynaptic AMPA-type glutamate receptors (AMPA receptors) is thought to mediate long-term depression (LTD), which is a synaptic plasticity model in various neuronal circuits.
Shinji Matsuda, Wataru Kakegawa, Michisuke Yuzaki   +2 more
doaj   +1 more source

Calcineurin Is Universally Involved in Vesicle Endocytosis at Neuronal and Nonneuronal Secretory Cells

Cell Reports, 2014
Calcium influx triggers and accelerates endocytosis in nerve terminals and nonneuronal secretory cells. Whether calcium/calmodulin-activated calcineurin, which dephosphorylates endocytic proteins, mediates this process is highly controversial for ...
Xin-Sheng Wu, Zhen Zhang, Wei-Dong Zhao, Dongsheng Wang, Fujun Luo, Ling-Gang Wu   +5 more
doaj   +1 more source