Results 71 to 80 of about 253,476 (302)

Exploiting Endocytosis for Nanomedicines [PDF]

Cold Spring Harbor Perspectives in Biology, 2013
In this article, we briefly review the endocytic pathways used by cells, pointing out their defining characteristics and highlighting physical limitations that may direct the internalization of nanoparticles to a subset of these pathways. A more detailed description of these pathways is presented in the literature.
Akinc, A., Battaglia, G.
openaire   +2 more sources

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Spatial segregation of BMP/Smad signaling affects osteoblast differentiation in C2C12 cells.

PLoS ONE, 2011
BackgroundBone morphogenetic proteins (BMPs) are involved in a plethora of cellular processes in embryonic development and adult tissue homeostasis.
Eva Heining, Raghu Bhushan, Pia Paarmann, Yoav I Henis, Petra Knaus   +4 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Endocytic Adaptors in Cardiovascular Disease

Frontiers in Cell and Developmental Biology, 2020
Endocytosis is the process of actively transporting materials into a cell by membrane engulfment. Traditionally, endocytosis was divided into three forms: phagocytosis (cell eating), pinocytosis (cell drinking), and the more selective receptor-mediated ...
Kui Cui, Kui Cui, Yunzhou Dong, Yunzhou Dong, Beibei Wang, Beibei Wang, Douglas B. Cowan, Douglas B. Cowan, Douglas B. Cowan, Siu-Lung Chan, Siu-Lung Chan, John Shyy, Hong Chen, Hong Chen   +13 more
doaj   +1 more source

Flowers for Synaptic Endocytosis [PDF]

Cell, 2009
Exocytosis and endocytosis of synaptic vesicles are tightly coordinated to maintain a steady supply of new vesicles during periods of extended neuronal stimulation. Yao et al. (2009) now report that a synaptic vesicle membrane protein named Flower promotes endocytosis at neuromuscular junctions in the fruit fly Drosophila.
Brose, Nils, Neher, Erwin
openaire   +5 more sources

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Blocking GSK3β-mediated dynamin1 phosphorylation enhances BDNF-dependent TrkB endocytosis and the protective effects of BDNF in neuronal and mouse models of Alzheimer's disease

Neurobiology of Disease, 2015
Endocytosis of tropomyosin related kinase B (TrkB) receptors has critical roles in brain-derived neurotrophic factor (BDNF) mediated signal transduction and biological function, however the mechanism that is governing TrkB endocytosis is still not ...
Xiang-Hua Liu, Zhao Geng, Jing Yan, Ting Li, Qun Chen, Qun-Ye Zhang, Zhe-Yu Chen   +6 more
doaj   +1 more source

Ultrasound Microbubble Treatment Enhances Clathrin-Mediated Endocytosis and Fluid-Phase Uptake through Distinct Mechanisms. [PDF]

PLoS ONE, 2016
Drug delivery to tumors is limited by several factors, including drug permeability of the target cell plasma membrane. Ultrasound in combination with microbubbles (USMB) is a promising strategy to overcome these limitations.
Farnaz Fekri, Ralph Christian Delos Santos, Raffi Karshafian, Costin N Antonescu   +3 more
doaj   +1 more source

Pacsin2 is required for endocytosis in the zebrafish pronephric tubule

Biology Open, 2022
Endocytosis mediates the cellular uptake of numerous molecules from the extracellular space and is a fundamentally important process. In the renal proximal tubule, the scavenger receptor megalin and its co-receptor cubilin mediate endocytosis of low ...
Joseph Morgan, Rebecca Yarwood, Tobias Starborg, Guanhua Yan, Martin Lowe   +4 more
doaj   +1 more source