Results 71 to 80 of about 249,281 (299)

Clathrin- and dynamin-independent endocytosis of FGFR3--implications for signalling. [PDF]

PLoS ONE, 2011
Endocytosis of tyrosine kinase receptors can influence both the duration and the specificity of the signal emitted. We have investigated the mechanisms of internalization of fibroblast growth factor receptor 3 (FGFR3) and compared it to that of FGFR1 ...
Ellen Margrethe Haugsten, Malgorzata Zakrzewska, Andreas Brech, Sascha Pust, Sjur Olsnes, Kirsten Sandvig, Jørgen Wesche   +6 more
doaj   +1 more source

Modulation of sleep by trafficking of lipids through the Drosophila blood-brain barrier

eLife, 2023
Endocytosis through Drosophila glia is a significant determinant of sleep amount and occurs preferentially during sleep in glia of the blood-brain barrier (BBB).
Fu Li, Gregory Artiushin, Amita Sehgal
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

An alternative mechanism of clathrin-coated pit closure revealed by ion conductance microscopy [PDF]

, 2012
Current knowledge of the structural changes taking place during clathrin-mediated endocytosis is largely based on electron microscopy images of fixed preparations and x-ray crystallography data of purified proteins.
Merrifield, C.J., Taylor, M, Ziyadeh-Isleem, A, Klenerman, D, Pavel Novak, Marc Bitoun, Lab, M.J., Merrifield, CJ, Guicheney, P., Pascale Guicheney, Novak, P, Gorelik, J., Ivan A. Diakonov, Diakonov, I.A., Klenerman, D., Marcus Taylor, Shevchuk, A.I., Andrew I. Shevchuk, Bitoun, M., Azza Ziyadeh-Isleem, Diakonov, IA, Korchev, Y.E., Bitoun, M, Korchev, YE, Taylor, M., Shevchuk, A., David Klenerman, Ziyadeh-Isleem, A., Lab, MJ, Merrifield, C., Gorelik, J, Novak, P., Christien J. Merrifield, Guicheney, P, Max J. Lab, Julia Gorelik, Diakonov, I., Korchev, Y., Yuri E. Korchev, Lab, M., Shevchuk, AI   +40 more
core   +1 more source

Spatial segregation of BMP/Smad signaling affects osteoblast differentiation in C2C12 cells.

PLoS ONE, 2011
BackgroundBone morphogenetic proteins (BMPs) are involved in a plethora of cellular processes in embryonic development and adult tissue homeostasis.
Eva Heining, Raghu Bhushan, Pia Paarmann, Yoav I Henis, Petra Knaus   +4 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Endocytic Adaptors in Cardiovascular Disease

Frontiers in Cell and Developmental Biology, 2020
Endocytosis is the process of actively transporting materials into a cell by membrane engulfment. Traditionally, endocytosis was divided into three forms: phagocytosis (cell eating), pinocytosis (cell drinking), and the more selective receptor-mediated ...
Kui Cui, Kui Cui, Yunzhou Dong, Yunzhou Dong, Beibei Wang, Beibei Wang, Douglas B. Cowan, Douglas B. Cowan, Douglas B. Cowan, Siu-Lung Chan, Siu-Lung Chan, John Shyy, Hong Chen, Hong Chen   +13 more
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Blocking GSK3β-mediated dynamin1 phosphorylation enhances BDNF-dependent TrkB endocytosis and the protective effects of BDNF in neuronal and mouse models of Alzheimer's disease

Neurobiology of Disease, 2015
Endocytosis of tropomyosin related kinase B (TrkB) receptors has critical roles in brain-derived neurotrophic factor (BDNF) mediated signal transduction and biological function, however the mechanism that is governing TrkB endocytosis is still not ...
Xiang-Hua Liu, Zhao Geng, Jing Yan, Ting Li, Qun Chen, Qun-Ye Zhang, Zhe-Yu Chen   +6 more
doaj   +1 more source

Endocytosis of nanomedicines

Journal of Controlled Release, 2010
Novel nanomaterials are being developed to improve diagnosis and therapy of diseases through effective delivery of drugs, biopharmaceutical molecules and imaging agents to target cells in disease sites. Such diagnostic and therapeutic nanomaterials, also termed “nanomedicines”, often require site-specific cellular entry to deliver their payload to sub ...
Kabanov, Alexander V., Sahay, Gaurav, Alakhova, Daria Y.   +2 more
openaire   +3 more sources