Results 61 to 70 of about 233,575 (303)

Synaptic Vesicle Endocytosis in Different Model Systems

Frontiers in Cellular Neuroscience, 2018
Neurotransmission in complex animals depends on a choir of functionally distinct synapses releasing neurotransmitters in a highly coordinated manner. During synaptic signaling, vesicles fuse with the plasma membrane to release their contents. The rate of
Quan Gan, Shigeki Watanabe, Shigeki Watanabe   +2 more
doaj   +1 more source

Clathrin- and dynamin-independent endocytosis of FGFR3--implications for signalling. [PDF]

PLoS ONE, 2011
Endocytosis of tyrosine kinase receptors can influence both the duration and the specificity of the signal emitted. We have investigated the mechanisms of internalization of fibroblast growth factor receptor 3 (FGFR3) and compared it to that of FGFR1 ...
Ellen Margrethe Haugsten, Malgorzata Zakrzewska, Andreas Brech, Sascha Pust, Sjur Olsnes, Kirsten Sandvig, Jørgen Wesche   +6 more
doaj   +1 more source

An alternative mechanism of clathrin-coated pit closure revealed by ion conductance microscopy [PDF]

, 2012
Current knowledge of the structural changes taking place during clathrin-mediated endocytosis is largely based on electron microscopy images of fixed preparations and x-ray crystallography data of purified proteins.
Merrifield, C.J., Taylor, M, Ziyadeh-Isleem, A, Klenerman, D, Pavel Novak, Marc Bitoun, Lab, M.J., Merrifield, CJ, Guicheney, P., Pascale Guicheney, Novak, P, Gorelik, J., Ivan A. Diakonov, Diakonov, I.A., Klenerman, D., Marcus Taylor, Shevchuk, A.I., Andrew I. Shevchuk, Bitoun, M., Azza Ziyadeh-Isleem, Diakonov, IA, Korchev, Y.E., Bitoun, M, Korchev, YE, Taylor, M., Shevchuk, A., David Klenerman, Ziyadeh-Isleem, A., Lab, MJ, Merrifield, C., Gorelik, J, Novak, P., Christien J. Merrifield, Guicheney, P, Max J. Lab, Julia Gorelik, Diakonov, I., Korchev, Y., Yuri E. Korchev, Lab, M., Shevchuk, AI   +40 more
core   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Bile acids reduce endocytosis of high-density lipoprotein (HDL) in HepG2 cells.

PLoS ONE, 2014
High-density lipoprotein (HDL) transports lipids to hepatic cells and the majority of HDL-associated cholesterol is destined for biliary excretion. Cholesterol is excreted into the bile directly or after conversion to bile acids, which are also present ...
Clemens Röhrl, Karin Eigner, Stefanie Fruhwürth, Herbert Stangl   +3 more
doaj   +1 more source

Modulation of sleep by trafficking of lipids through the Drosophila blood-brain barrier

eLife, 2023
Endocytosis through Drosophila glia is a significant determinant of sleep amount and occurs preferentially during sleep in glia of the blood-brain barrier (BBB).
Fu Li, Gregory Artiushin, Amita Sehgal
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Spatial segregation of BMP/Smad signaling affects osteoblast differentiation in C2C12 cells.

PLoS ONE, 2011
BackgroundBone morphogenetic proteins (BMPs) are involved in a plethora of cellular processes in embryonic development and adult tissue homeostasis.
Eva Heining, Raghu Bhushan, Pia Paarmann, Yoav I Henis, Petra Knaus   +4 more
doaj   +1 more source

Functional analysis of TOR complex 2 and its control of sphingolipid biosynthesis in "Saccharomyces cerevisiae" [PDF]

, 2006
sphingoid base, one of the intermediate of sphingolipids metabolites, plays a key role as a signaling molecule which activate PKH kinases and its substrates YPKs and PKC1 (Casamayor, Torrance et al. 1999; Friant, Lombardi et al.
Shioda, Ryo
core   +1 more source

Pneumolysin boosts the neuroinflammatory response to Streptococcus pneumoniae through enhanced endocytosis [PDF]

, 2022
In pneumococcal meningitis, bacterial growth in the cerebrospinal fluid results in lysis, the release of toxic factors, and subsequent neuroinflammation.
Förtsch, Christina, Mitchell, Timothy J., Hupp, Sabrina, Graber, Franziska, Iliev, Asparouh I., Mitchell, Timothy J, Iliev, Asparouh I   +6 more
core   +1 more source