Results 231 to 240 of about 361,769 (340)

Hypercapnia Effects on Lung Function. [PDF]

Compr Physiol
Choi S, Dada LA, Sznajder JI.
europepmc   +1 more source

Reviewer #2 (Public review): Vesiculation pathways in clathrin-mediated endocytosis

Xinran Wang, Julien Berro, Rui Ma
openalex   +1 more source

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

Advanced Science, EarlyView.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello, Sandra Hauser, Michael Seifert, Christopher K. Barlow, Joel R. Steele, Emma Salisbury, Daniel Croagh, Kathryn S. Stok, Anna V. Taubenberger, Ralf B. Schittenhelm, Daniela Loessner   +10 more
wiley   +1 more source

Roles in physiology and disease of the inositol phosphatase synaptojanin 1. [PDF]

Biochim Biophys Acta Mol Cell Biol Lipids
De Camilli P.
europepmc   +1 more source

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

Advanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li, Xueqi He, Xinyuan Hao, Yu Zhang, Xin Zhao, Shuang Wang, Zhenru Wang, Haonan Du, Hongda Li, Lian Yi, Zhimin Du, Weijie Du   +11 more
wiley   +1 more source

SARS-CoV-2 evolution enhances endocytic uptake while preserving TMPRSS2-dependent fusion. [PDF]

Front Immunol
Magnus CL, Jaber ZH, Hiergeist A, Arnold L, Marchel H, Lamprecht A, Hanses F, Dienemann T, Schneckenpointner R, Lubnow M, Müller T, Lunz D, Hitzenbichler F, Schmid S, Müller M, Poeck H, Graf B, Salzberger B, Gessner A, Schmidt B, Schuster P.   +20 more
europepmc   +1 more source

Membrane‐Mediated Force Transduction Drives Stick‐Slip Motion of Lipid Vesicles

Advanced Science, EarlyView.
A rotating magnetic field actuates a ferromagnetic particle inside a lipid vesicle, generating internal flows that induce stick‐slip propulsion near a surface. Membrane properties—elasticity, excess area, and phase behavior—modulate this motion by shaping stress dissipation and force transduction.
Paula Magrinya, Arin Escobar Ortiz, Juan L. Aragones, Laura R. Arriaga   +3 more
wiley   +1 more source

Antibody-induced internalization and degradation of PLA2R amplifies CD4⁺ T cell activation. [PDF]

Theranostics
Liu Y, Li Y, Zhou H, Yu J, Deng P, Xu W, Pan B, Zhang L, Zhou H, Zhang J, Liu X, Shi M, Dong X, Tong B, Bi E, Guo N, Hu Y.   +16 more
europepmc   +1 more source

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

The intracellular domains of the DSL ligands Serrate and Delta provide different activities. [PDF]

Cell Commun Signal
Seib E, Schmid M, Shimizu H, Troost T, Oyelere SF, Chakraborty B, Baron M, Klein T.   +7 more
europepmc   +1 more source