Results 251 to 260 of about 343,817 (360)

Topological Scaffold‐Based Trispecific Recombinant Protein‐Drug Conjugates for Solid Tumor Eradication

Advanced Science, EarlyView.
A novel tri‐specific recombinant protein and its drug conjugate are developed, named sRP‐EHI and sRPDC‐EHI, which feature a star‐shaped topological structure. It can simultaneously bind the EGFR, HER2, and integrin αvβ3 overexpressed in cancer cells.
Huiyi Jiang, Yang Yuan, Xiaoke Zhang, Weizhi Chen, Hui Mao, Baorui Liu, Xiqun Jiang   +6 more
wiley   +1 more source

Maintenance of proper phosphatidylinositol-4-phosphate level by Stt4 and Sac1 contributes to vesicular transport to and from the plasma membrane. [PDF]

J Biol Chem
Sano T, Nagano M, Shimamura H, Yamamoto W, Tamada T, Toshima JY, Toshima J.   +6 more
europepmc   +1 more source

Endocytosis [PDF]

Cell, 2001
openaire   +2 more sources

Remodeling the Physicochemical and Pharmacokinetic Properties of PROTAC via Lipid Nanodisks for Cancer Therapy

Advanced Science, EarlyView.
To solve the challenge of PROTACs in clinical potential due to poor water solubility and membrane permeability, a nanodelivery system based on lipid nanodisks loaded with MZ1 prodrug (LND‐MZ1) to remodel the physicochemical and pharmacokinetic properties of PROTAC MZ1 is elaborately proposed.
Meichen Pan, Chunrong Yang, Zhongliang Fu, Yuchen Yang, Ying Zhuo, Hongwei Hou, Jinghong Li   +6 more
wiley   +1 more source

Transferrin receptor 1 (TfR1) functions as an entry receptor for scale drop disease virus to invade the host cell via clathrin-mediated endocytosis. [PDF]

J Virol
Chen J, Fu Y, Li Y, Weng S, Wang H, He J, Dong C.   +6 more
europepmc   +1 more source

ConnectING endocytosis [PDF]

Nature Reviews Cancer, 2013
openaire   +3 more sources

Harnessing the Immunomodulation of UV‐Exposed Keratinocyte Extracellular Vesicles for Inflammatory Disorder Treatment

Advanced Science, EarlyView.
Adopting a paradigm shift that transforms a known health hazard as a potential therapeutic asset, a novel therapeutic strategy is set out to investigate for inflammatory conditions by leveraging immunosuppressive properties of UV‐irradiated keratinocytes.
Lu Liu, Ding Yang, Jingsen Ji, Gengyou Li, Haoting Chen, Yuying Yao, Chenxing Fu, Fangling Liao, Jinzhao Liu, Yaming Zhang, Zechuan Li, Jing Zhang, Huike Ma, Jingxia Zhao, Ying‐Shi Sun, Weisheng Guo, Weiping Wang   +16 more
wiley   +1 more source

FMRP-dependent translational control negatively regulates adapter protein complex 2-mediated endocytosis. [PDF]

iScience
Shi L, Kosti A, Raj N, Sun J, Gao Y, Simamora R, Valdez-Sinon AN, Faundez V, Bassell GJ.   +8 more
europepmc   +1 more source

Independence of type I angiotensin II receptor endocytosis from G protein coupling and signal transduction.

, 1994
László Hunyady, Albert J. Baukal, Tamás Balla, Kevin Catt   +3 more
openalex   +1 more source

Oral Engineered Extracellular Vesicles Based on Ion Exchange Strategy for Multipronged Management of Wilson's Disease Complicated with Reproductive Dysfunction Therapy

Advanced Science, EarlyView.
This study reports for the first time an oral targeted nanomedicine that conducts ion exchange through engineered Ganoderma‐derived extracellular vesicle, managing both the in‐copper and ex‐copper in a multi‐pronged approach, offering a promising therapeutic strategy for addressing WD with reproductive dysfunction.
Tingting Wang, Wengui Lu, Zhifei Cheng, Luyao Wang, Zhenzhen Jiang, Yike Yue, Pengyu Jiang, Zehua Xia, Lei He, Fengying Wang, Limin Wu, Qi Wang, Hui Han   +12 more
wiley   +1 more source