Ubiquitin-dependent endocytosis of NKG2D-DAP10 receptor complexes activates signaling and functions in human NK cells [PDF]
, 2015 Cytotoxic lymphocytes share the presence of the activating receptor NK receptor group 2, member D (NKG2D) and the signaling-competent adaptor DNAX-activating protein 10 (DAP10), which together play an important role in antitumor immune surveillance ...
CAPUANO, CRISTINA +9 more
core +1 more source
Calcium-Independent Exo-endocytosis Coupling at Small Central Synapses
Cell Reports, 2019 Summary: At presynaptic terminals, neurotransmitters are released by synaptic vesicle exocytosis at the active zone. In order to maintain efficient neurotransmission and proper synaptic structure, sites of vesicle fusion must be cleared rapidly by ...
Marta Orlando +3 more
doaj +1 more source
A neurotoxic phospholipase A2 impairs yeast amphiphysin activity and reduces endocytosis. [PDF]
PLoS ONE, 2012 BACKGROUND: Presynaptically neurotoxic phospholipases A(2) inhibit synaptic vesicle recycling through endocytosis. PRINCIPAL FINDINGS: Here we provide insight into the action of a presynaptically neurotoxic phospholipase A(2) ammodytoxin A (AtxA) on ...
Mojca Mattiazzi +9 more
doaj +1 more source
Real-time visualization of clustering and intracellular transport of gold nanoparticles by correlative imaging. [PDF]
, 2017 Mechanistic understanding of the endocytosis and intracellular trafficking of nanoparticles is essential for designing smart theranostic carriers. Physico-chemical properties, including size, clustering and surface chemistry of nanoparticles regulate ...
Chen, Nan +13 more
core +2 more sources
The Mechanochemistry of Endocytosis
PLoS Biology, 2009 Endocytic vesicle formation is a complex process that couples sequential protein recruitment and lipid modifications with dramatic shape transformations of the plasma membrane. Although individual molecular players have been studied intensively, how they all fit into a coherent picture of endocytosis remains unclear.
Yidi Sun +3 more
openaire +4 more sources
Target shape dependence in a simple model of receptor-mediated endocytosis and phagocytosis [PDF]
, 2016 Phagocytosis and receptor-mediated endocytosis are vitally important particle uptake mechanisms in many cell types, ranging from single-cell organisms to immune cells.
Endres, Robert G., Richards, David M.
core +2 more sources
Cellular Physiology and Biochemistry, 2014 Background: In intestinal epithelial cells, acute regulation of the brush border Na+/H+ exchanger, NHE3, usually occurs by changes in endocytosis and/or exocytosis. Constitutive NHE3 endocytosis involves clathrin.
Nicholas C. Zachos +4 more
doaj +1 more source
Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand [PDF]
, 1992 We have constructed an artificial ligand for the hepatocyte-specific asialoglycoprotein receptor for the purpose of generating a synthetic delivery system for DNA.
Christian Plank +4 more
openalex +3 more sources
FM1-43 reveals membrane recycling in adult inner hair cells of the mammalian cochlea [PDF]
, 2002 Neural transmission of complex sounds demands fast and sustained rates of synaptic release from the primary cochlear receptors, the inner hair cells (IHCs). The cells therefore require efficient membrane recycling.
Ashmore, JF +2 more
core +1 more source
A functional study of AUXILIN-LIKE1 and 2, two putative clathrin uncoating factors in Arabidopsis [PDF]
, 2018 Clathrin-mediated endocytosis (CME) is a cellular trafficking process in which cargoes and lipids are internalized from the plasma membrane into vesicles coated with clathrin and adaptor proteins. CME is essential for many developmental and physiological
Adamowski, Maciek +5 more
core +1 more source