Results 111 to 120 of about 73,519 (232)

Xenotransplantation at a Crossroads: Breakthroughs, Challenges, and the Path Forward

Organ Medicine, EarlyView.
Xiaoyu Gan, Jizhang Yu, Jie Wu, Junjie Zong   +3 more
wiley   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, Volume 600, Issue 3, Page 370-382, February 2026.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Genome-wide characterization and comparison of endogenous retroviruses among 3 duck reference genomes

Poultry Science
: Endogenous retroviruses (ERV) are viral genomes integrated into the host genome and can be stably inherited. Although ERV sequences have been reported in some avian species’ genome, the duck endogenous retroviruses (DERV) genome has yet to be ...
Yuan Bai, Yang Xi, Xinxin He, Grace Twumasi, Shengchao Ma, Qiuyu Tao, Mengru Xu, Shuaixue Jiang, Tao Zhang, Yinjuan Lu, Xu Han, Jingjing Qi, Liang Li, Lili Bai, Hehe Liu   +14 more
doaj   +1 more source

Indirect induction of radiation lymphomas in mice. Evidence for a novel, transmissible leukemogen. [PDF]

, 1987
The transmission of a lymphomagenic agent(s) from the bone marrow of irradiated mice to thymic target cells has been demonstrated by: (a) the induction of T cell lymphomas in nonirradiated thymic grafts implanted in irradiated, Thy-l-congenic mice, (b ...
Hansteen, GA, Lieberman, M, McCune, JM, Scott, ML, Weissman, IL, White, JH   +5 more
core  

Identification of novel subgroup a variants with enhanced receptor binding and replicative capacity in primary isolates of anaemogenic strains of feline leukaemia virus [PDF]

, 2012
<b>BACKGROUND:</b> The development of anaemia in feline leukaemia virus (FeLV)-infected cats is associated with the emergence of a novel viral subgroup, FeLV-C.
A Manrique, AJ Phipps, AS McDougall, Brian J Willett, C Chandhasin, C Munk, CP Geret, CS Tailor, D Onions, EA Hoover, Elizabeth L McMonagle, ES Svarovskaia, FL Graham, G Towers, GA Dean, H Chen, Hazel Stewart, J Brojatsch, J Hartikka, JG Quigley, JG Quigley, JI Mullins, JK Brown, Karen W Adema, KS Levesque, L Mackey, LL Bolin, M Gouy, M Reinacher, MA Rey, MA Rigby, MA Stewart, Margaret J Hosie, MM Anderson, N Hussain, N Riedel, N Riedel, NC Pedersen, O Jarrett, O Jarrett, O Jarrett, O Jarrett, O Jarrett, O Jarrett, OB Spiller, PH Russell, PM Rwambo, PR Donahue, PS Sarma, R Mendoza, R Pandey, RL Sheets, S Boomer, S Nakowitsch, T Ohashi, WD Hardy, WD Hardy, WD Hardy, Z Shalev   +58 more
core   +3 more sources

Targeting DESI2 as a Novel Therapeutic Strategy for JAK2‐Mutant Leukemias

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Mass spectrometry‐based proteomics identify DESI2 as a novel component of the JAK2‐V617F complex, which associates with and stabilizes mutant JAK2 through deSUMOylation and deubiquitination, therefore promoting JAK2 mutant cell growth and MPN disease onset in vivo.
Husheng Mei, Wuqiang Wen, Wenjun Zhang, Shujing Zhang, Ting Sun, Guiming Li, Jing Zhang, Shuang Qi, Jie Zhou, Bing Li, Yunshuo Zhao, Xiaotong Chen, Bowen Li, Yiying Xue, Wang Lu, Yanli Sun, Jingyao Wang, Hengyue Shan, Shengzhe Zhang, Yushan Huang, Yisa Chen, Wenchao Wang, Qingsong Liu, Wenchao Lu, Li Tan, Yi Ding, Jianfei Fu, Jun Long, Lei Zhang, Baobing Zhao, Aibin Liang, Baishan Jiang, Jing Yang   +32 more
wiley   +1 more source

Epigenetic motifs distinguishing endogenous from exogenous retroviral integrants

Journal of Virology
Retroviruses are subject to epigenetic regulation by the host genome after integrating, similar to vertebrate genes. However, their patterns of integration, and therefore their likely epigenetic regulation, differ between genera.
Sarah LaMere, Hanbei Xiong, Wei Wang, Brian LaMere, Niema Moshiri   +4 more
doaj   +1 more source

Characterization of the human endogenous retrovirus K proteinase

Journal of General Virology, 1996
The proteinase of the human endogenous retrovirus K (HERV-K) shows similarity to retrovirus aspartic proteinases. It is translated from a transcript composed of gag and prt. The proteinase was expressed either as full-length native protein or as truncated protein in Escherichia coli.
S, Schommer, M, Sauter, H G, Kräusslich, B, Best, N, Mueller-Lantzsch   +4 more
openaire   +2 more sources

Engineering Immortalized Bovine Granulosa Cells Using a Triple‐Gene Approach: Mutant CDK4, Cyclin D1, and TERT

Cell Biology International, Volume 50, Issue 2, February 2026.
ABSTRACT Advancing reproductive technologies in livestock is essential to improve both productivity and genetic potential of cattle. Despite this importance, application of reproductive biotechnologies in cattle breeding remains limited. Bovine granulosa cells (bGCs), which are key components of the ovarian follicle, are critical in female reproduction
Lanlan Bai, Minami Takahashi, Jin Kobayashi, Takahiro Eitsuka, Himari Matsusaka, Taku Ozaki, Eriko Sugano, Hiroshi Tomita, Yuan Xu, Kazuhiro Kawamura, Kiyotaka Nakagawa, Tohru Kiyono, Tomokazu Fukuda   +12 more
wiley   +1 more source

Aerobic Exercise Promotes Hippocampal Neurogenesis and Ameliorates Cognitive Dysfunction Induced by Unilateral Labyrinthectomy

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
UL induced significant spatial and non‐spatial cognitive dysfunction and hippocampal neurogenesis inhibition, whereas aerobic exercise intervention effectively reversed these impairments. Transcriptomic profiling and pharmacological evidence identified MHC class I/II–related pathways (H2‐K1, H2‐Eb1, CD74) as key mediators of the restorative effects of ...
Zhanghong Zhou, Xixi Yu, E. Tian, Zhaoqi Guo, Jingyu Chen, Jiaqi Guo, Shiyu Shi, Wandi Xu, Ni Zhai, Caijuan Qiao, Yuejin Zhang, Jun Wang, Yisheng Lu, Sulin Zhang   +13 more
wiley   +1 more source