Osteoarthritis: Mechanisms and Therapeutic Advances
A schematic illustration of the pathogenesis and emerging therapeutic strategies for OA, including: risk factors and molecular mechanisms of OA, joint changes between healthy and OA conditions, and current emerging therapeutic approaches for OA. Abbreviations: IA: intra‐articular injection; EVs: extracellular vesicles. ABSTRACT Osteoarthritis (OA) is a
Wei Liu+3 more
wiley +1 more source
Novel Endogenous Type C Retrovirus in Baboons: Complete Sequence, Providing Evidence for Baboon Endogenous Virus gag-pol Ancestry [PDF]
Rui Mang+2 more
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Retrotransposable element (RTE) expression increases with chronological and biological age and is negatively associated with heterochromatin regulators. Moreover, RTE expression shows sex‐specific differences, with higher levels in men and enrichment for immune‐related pathways.
Valentina Talevi+6 more
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A Human Endogenous Retrovirus Suppresses Translation of an Associated Fusion Transcript, PLA2L [PDF]
Paul E. Kowalski, Dixie L. Mager
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Genomic imprinting at a porcine ZNF locus via a canonical imprinting mechanism
Abstract Genomic imprinting causes parent‐of‐origin dependent gene expression, primarily driven by a subset of germline differentially methylated regions that function as imprinting control regions at promoter‐associated CpG islands. While these mechanisms have been investigated in depth in mice and humans, our understanding of the molecular basis of ...
Jinsoo Ahn+5 more
wiley +1 more source
A replication-competent, endogenous retrovirus from an aged DBA/2 mouse contains the complete env from Emv-3 and a novel gag partially related to AKT-8 [PDF]
Thomas Bartman+2 more
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Causes of mortality in koalas autopsied at the University of Melbourne
Objective To determine the causes of mortality in koalas autopsied at the University of Melbourne based on the retrospective analysis of autopsy reports. Methods The autopsy reports of 239 koalas examined at the University of Melbourne from 1970 to 2023 were reviewed to determine which of the comorbidities present was the primary cause to which death ...
L Wilson+8 more
wiley +1 more source
Physiological Knockout of the Envelope Gene of the Single-Copy ERV-3 Human Endogenous Retrovirus in a Fraction of the Caucasian Population [PDF]
Nathalie de Parseval, Thiérry Heidmann
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Advances in the Study of Pluripotent Stem Cells in Livestock
Livestock pluripotent stem cells include embryonic stem cells (ESCs) isolated from the inner cell mass of blastocysts and induced pluripotent stem cells (iPSCs) derived from somatic cell reprogramming. They hold significant potential for applications in livestock breed improvement, rapid propagation, human disease modelling and human organ ...
Xinyi Zhou+6 more
wiley +1 more source
HOST RANGE AND INTERFERENCE STUDIES OF THREE CLASSES OF PIG ENDOGENOUS RETROVIRUS [PDF]
Yasuhiro Takeuchi+6 more
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