Endogenous MMTV proviruses induce susceptibility to both viral and bacterial pathogens.
PLoS Pathogens, 2006 Most inbred mice carry germline proviruses of the retrovirus, mouse mammary tumor virus (MMTV) (called Mtvs), which have multiple replication defects. A BALB/c congenic mouse strain lacking all endogenous Mtvs (Mtv-null) was resistant to MMTV oral and ...
Sanchita Bhadra +3 more
doaj +1 more source
Generation of Cloned Sheep Lacking Galactose‐α1,3‐Galactose and N‐Glycolylneuraminic Acid Antigens
Xenotransplantation, Volume 33, Issue 3, May/June 2026.ABSTRACT Livestock have long been regarded as a potential source of donor organs to alleviate the global organ shortage for transplantation. Sheep have a similar anatomy to humans, providing the standard model for demonstrating biocompatibility and performance of biological heart valves to obtain regulatory approval for their use in transplantation ...
Sarah J. Appleby +9 more
wiley +1 more source
eLife, 2017 Primates have co-opted a viral gene to produce an envelope protein that prevents infection by the HERV-T virus and likely contributed to the extinction of this virus.
Julia H Wildschutte, John M Coffin
doaj +1 more source
Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells [PDF]
, 2002 In the vertebrate peripheral nervous system, the proneural genes neurogenin 1 and neurogenin 2 (Ngn1 and Ngn2), and Mash1 are required for sensory and autonomic neurogenesis, respectively.
Anderson, David J. +3 more
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MASH1 activates expression of the paired homeodomain transcription factor Phox2a, and couples pan-neuronal and subtype-specific components of autonomic neuronal identity [PDF]
, 1998 We have investigated the genetic circuitry underlying the determination of neuronal identity, using mammalian peripheral autonomic neurons as a model system.
Anderson, David J. +2 more
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Impacts of endogenous retroviruses on tumorigenesis, immunity, stem cells and research safety
Frontiers in Oncology, 2014 Iyoko eKatoh
doaj +1 more source
Is it currently possible to evaluate the risk posed by PERVs for clinical xenotransplantation? [PDF]
, 2018 Denner, Joachim +2 more
core +1 more source
Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene. [PDF]
, 1995 To determine the functional importance of Ras in transformation by Abl oncogenes, we used a genetic approach to measure the effect of impaired Ras activity on the ability of Bcr-Abl or v-Abl to transform cells.
McLaughlin, J, Sawyers, CL, Witte, ON
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SRSF2 Is Essential For Hematopoiesis and Its Mutations Dysregulate Alternative RNA Splicing In MDS [PDF]
, 2013 Myelodysplastic syndromes (MDS) are a group of neoplasms that are ineffective in generating multiple lineages of myeloid cells and have various risks to progress to acute myeloid leukemia.
Chen, Liang +10 more
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Extracellular vesicles transfer nuclear Abl-dependent and radiation-induced miR-34c into unirradiated cells to cause bystander effects. [PDF]
, 2018 Ionizing radiation (IR) not only activates DNA damage response (DDR) in irradiated cells but also induces bystander effects (BE) in cells not directly targeted by radiation.
Chan, Josolyn +3 more
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