Results 111 to 120 of about 71,944 (228)
Epigenetic motifs distinguishing endogenous from exogenous retroviral integrants
Journal of VirologyRetroviruses are subject to epigenetic regulation by the host genome after integrating, similar to vertebrate genes. However, their patterns of integration, and therefore their likely epigenetic regulation, differ between genera.
Sarah LaMere +4 more
doaj +1 more source
Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle. [PDF]
, 1996 Viral oncoproteins that inactivate the retinoblastoma tumor suppressor protein (pRb) family both block skeletal muscle differentiation and promote cell cycle progression.
Jacks, T +3 more
core
TRIM28-Regulated Transposon Repression Is Required for Human Germline Competency and Not Primed or Naive Human Pluripotency. [PDF]
, 2018 Transition from primed to naive pluripotency is associated with dynamic changes in transposable element (TE) expression and demethylation of imprinting control regions (ICRs).
Chen, Pao-Yang +9 more
core +2 more sources
Characterization of the human endogenous retrovirus K proteinase
Journal of General Virology, 1996 The proteinase of the human endogenous retrovirus K (HERV-K) shows similarity to retrovirus aspartic proteinases. It is translated from a transcript composed of gag and prt. The proteinase was expressed either as full-length native protein or as truncated protein in Escherichia coli.
S, Schommer +4 more
openaire +2 more sources
MedComm, Volume 7, Issue 5, May 2026.There is global immunosuppression during CML initiation and progression, which is directly driven by BCR–ABL1 expressing CML cells. On one hand, the BCR–ABL1 oncogene drives the differentiation of leukemia cells toward the neutrophil lineage. On the other hand, the oncogene also transcriptionally activates master immune regulators, including arginase ...
Xiaocui Lu +14 more
wiley +1 more source
Indirect induction of radiation lymphomas in mice. Evidence for a novel, transmissible leukemogen. [PDF]
, 1987 The transmission of a lymphomagenic agent(s) from the bone marrow of irradiated mice to thymic target cells has been demonstrated by: (a) the induction of T cell lymphomas in nonirradiated thymic grafts implanted in irradiated, Thy-l-congenic mice, (b ...
Hansteen, GA +5 more
core
Disruption of fusion results in mitochondrial heterogeneity and dysfunction [PDF]
, 2005 Mitochondria undergo continual cycles of fusion and fission, and the balance of these opposing processes regulates mitochondrial morphology. Paradoxically, cells invest many resources to maintain tubular mitochondrial morphology, when reducing both ...
Chan, David C. +2 more
core +2 more sources
Brain Pathology, Volume 36, Issue 3, May 2026.Increases in sphingomyelin in response to TDP‐43 pathology in the disease‐affected motor cortex of amyotrophic lateral sclerosis (ALS) brain. Abstract Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease characterized by the degeneration of motor neurons and the presence of TAR DNA‐binding protein 43 (TDP‐43 ...
Finula I. Isik +4 more
wiley +1 more source
Definition and variation of human endogenous retrovirus H
Virology, 2004 We defined the abundant human endogenous retrovirus group HERV-H based on pol similarity. Among 3661 pol-containing elements, 1124 integrations were similar to HERV-H RGH2 pol using translated pol sequences. A clustering procedure lessened these to 234 representatives, amenable to detailed study.
Jern, Patric +2 more
openaire +2 more sources
Xenoperfusion—The Transformative Role of Machine Perfusion in Xenotransplantation
Xenotransplantation, Volume 33, Issue 3, May/June 2026.ABSTRACT Recent advances in xenotransplantation have gained substantial public and clinical attention as genetically modified porcine organs are now being transplanted into living human recipients. While only case reports have been published to date, the first clinical trials for kidney xenotransplantation are now ongoing.
Florian Huwyler +3 more
wiley +1 more source