Results 21 to 30 of about 604,863 (290)
Human endogenous retrovirus K in the respiratory tract is associated with COVID-19 physiopathology
Microbiome, 2022 Background Critically ill 2019 coronavirus disease (COVID-19) patients under invasive mechanical ventilation (IMV) are 10 to 40 times more likely to die than the general population.
J. Temerozo +24 more
semanticscholar +1 more source
Association between Human Endogenous Retrovirus K gene expression and breast cancer
Cellular, Molecular and Biomedical Reports, 2021 showed that the increase in mRNA expression was positive in 64% of patients with breast cancer and negative in all healthy individuals. The results indicate an increase in the expression of endogenous human retroviruses (HERVs) in breast cancer.
M. Tourang +3 more
semanticscholar +1 more source
Pathological manifestation of human endogenous retrovirus K in frontotemporal dementia
Communications Medicine, 2021 Behavioral variant frontotemporal dementia (bvFTD) is a common form of younger-onset dementia with a proportion of cases overlapping pathologically and genetically with amyotrophic lateral sclerosis (ALS).
Katherine Phan +13 more
semanticscholar +1 more source
Cancer Research, 2021 The endogenous retrovirus HERV-K activates oncogenic signaling pathways and promotes proliferation of Merlin-deficient schwannomas and meningiomas, which can be targeted with antiretroviral drugs and TEAD inhibitors.
E. Maze +10 more
semanticscholar +1 more source
SETDB1 Restrains Endogenous Retrovirus Expression and Antitumor Immunity during Radiotherapy
Cancer Research, 2022 The identification of the SETDB1-mediated suppression of radiotherapy-induced viral mimicry reveals SETDB1 inhibition as a potential approach to sensitize tumors to radiotherapy by enhancing the type I interferon response.
Dong Pan +5 more
semanticscholar +1 more source
The restriction of zoonotic PERV transmission by human APOBEC3G. [PDF]
PLoS ONE, 2007 The human APOBEC3G protein is an innate anti-viral factor that can dominantly inhibit the replication of some endogenous and exogenous retroviruses. The prospects of purposefully harnessing such an anti-viral defense are under investigation.
Stefán R Jónsson +5 more
doaj +1 more source
Embryonic stem cell potency fluctuates with endogenous retrovirus activity
Nature, 2012 Todd S Macfarlan +2 more
exaly +3 more sources
Journal of Experimental Medicine, 2021 Using ERVmap, the authors determined that ERV-K102 expression was elevated in SLE patients’ peripheral blood cells and correlated with the interferon signature.
M. Tokuyama +9 more
semanticscholar +1 more source
Human Endogenous Retrovirus as Therapeutic Targets in Neurologic Disease
Pharmaceuticals, 2021 Human endogenous retroviruses (HERVs) are ancient retroviral DNA sequences established into germline. They contain regulatory elements and encoded proteins few of which may provide benefits to hosts when co-opted as cellular genes. Their tight regulation
Karen Giménez-Orenga, E. Oltra
semanticscholar +1 more source
The Kidney-Associated Microbiome of Wild-Caught Artibeus spp. in Grenada, West Indies
Animals, 2021 Bats are capable of asymptomatically carrying a diverse number of microorganisms, including human pathogens, due to their unique immune system. Because of the close contact between bats and humans, there is a possibility for interspecies transmission and
Maria E. Ramos-Nino +5 more
doaj +1 more source