Results 21 to 30 of about 73,519 (232)
Frontiers in Oncology, 2021 Neuroblastoma (NB) is the commonest solid tumor outside the central nervous system in infancy and childhood with a unique biological heterogeneity. In patients with advanced, metastasizing neuroblastoma, treatment failure and poor prognosis is often ...
Lisa Wieland +8 more
doaj +1 more source
Endogenous retrovirus envelope as a tumor-associated immunotherapeutic target in murine osteosarcoma
iScience, 2021 Summary: Osteosarcoma remains one of the deadliest cancers in pediatrics and young adults. We administered two types of immunotherapies, oncolytic virotherapy and immune checkpoint inhibition, to two murine osteosarcoma models and observed divergent ...
Mary Frances Wedekind +15 more
doaj +1 more source
Are dogs not susceptible to retroviral infections?
Animal Diseases, 2023 Retroviruses have been proven to cause infections and diseases in a series of mammalian hosts but not in dogs. Then, this letter discussed the dog susceptibility to retrovirus infection, encompassing arguments to understand why dogs may have not been ...
Jorge Casseb +2 more
doaj +1 more source
The restriction of zoonotic PERV transmission by human APOBEC3G. [PDF]
PLoS ONE, 2007 The human APOBEC3G protein is an innate anti-viral factor that can dominantly inhibit the replication of some endogenous and exogenous retroviruses. The prospects of purposefully harnessing such an anti-viral defense are under investigation.
Stefán R Jónsson +5 more
doaj +1 more source
Transspecies Transmission of the Endogenous Koala Retrovirus [PDF]
Journal of Virology, 2006 ABSTRACTThe koala retrovirus (KoRV) is a gammaretrovirus closely related to the gibbon ape leukemia virus and induces leukemias and immune deficiencies associated with opportunistic infections, such as chlamydiosis. Here we characterize a KoRV newly isolated from an animal in a German zoo and show infection of human and rat cell lines in vitro and of ...
Uwe, Fiebig +4 more
openaire +2 more sources
Novel Endogenous Retrovirus in Rabbits Previously Reported as Human Retrovirus 5 [PDF]
Journal of Virology, 2002 ABSTRACT Human retrovirus 5 (HRV-5) represented a fragment of a novel retrovirus sequence identified in human RNA and DNA preparations. In this study, the genome of HRV-5 was cloned and sequenced and integration sites were analyzed. Using PCR and Southern hybridization, we showed that HRV-5 is not integrated into human DNA.
David J, Griffiths +3 more
openaire +2 more sources
Endogenous retrovirus-mediated genomic variations in chimpanzees [PDF]
Mobile Genetic Elements, 2014 Transposable elements (TEs) have played a significant role in the evolution of host genome by triggering genomic rearrangements. TEs have been studied in various research fields, ranging from population genomics to personalized medicines. Human-specific TEs and TEs existing in the human genome have been well studied.
Yun-Ji, Kim, Kyudong, Han
openaire +2 more sources
Genetic Diversity of Koala Retroviral Envelopes
Viruses, 2015 Genetic diversity, attributable to the low fidelity of reverse transcription, recombination and mutation, is an important feature of infectious retroviruses.
Wenqin Xu +4 more
doaj +1 more source
Regression/eradication of gliomas in mice by a systemically-deliverable ATF5 dominant-negative peptide. [PDF]
, 2016 Malignant gliomas have poor prognosis and urgently require new therapies. Activating Transcription Factor 5 (ATF5) is highly expressed in gliomas, and interference with its expression/function precipitates targeted glioma cell apoptosis in vitro and in ...
Angelastro, James +11 more
core +2 more sources
Origin and recent expansion of an endogenous gammaretroviral lineage in domestic and wild canids
Retrovirology, 2019 Background Vertebrate genomes contain a record of retroviruses that invaded the germlines of ancestral hosts and are passed to offspring as endogenous retroviruses (ERVs).
Julia V. Halo +5 more
doaj +1 more source