Results 31 to 40 of about 47,195 (209)

Spatiotemporal variations in retrovirus-host interactions among Darwin’s finches

Nature Communications, 2022
Endogenous retroviruses (ERV) are inherited remains of retroviruses that have colonized host genomes during evolution. Here the authors observe considerable species-specific ERV variation among Darwin’s finches, reflecting historic retrovirus-host ...
Jason Hill, Mette Lillie, Mats E. Pettersson, Carl-Johan Rubin, B. Rosemary Grant, Peter R. Grant, Leif Andersson, Patric Jern   +7 more
doaj   +1 more source

Cooccurrences of Putative Endogenous Retrovirus-Associated Diseases [PDF]

BioMed Research International, 2017
At least 8% of the human genome is composed of endogenous retrovirus (ERV) sequences. ERVs play a role in placental morphogenesis and can sometimes protect the host against exogenous viruses. On the other hand, ERV reactivation has been found to be associated with different diseases, for example, multiple sclerosis (MS), schizophrenia, type 1 diabetes ...
Christine Brütting, Alexander Emmer, Malte E. Kornhuber, Martin S. Staege   +3 more
openaire   +2 more sources

Endogenous retrovirus activation: potential for immunology and clinical applications. [PDF]

Natl Sci Rev
Yu J, Qiu P, Ai J, Liu B, Han GZ, Zhu F, Zhang W, Cui J.   +7 more
europepmc   +3 more sources

Investigation of Endogenous Retrovirus Sequences in the Neighborhood of Genes Up-regulated in a Neuroblastoma Model after Treatment with Hypoxia-Mimetic Cobalt Chloride

Frontiers in Microbiology, 2018
Human endogenous retroviruses (ERVs) have been found to be associated with different diseases, e.g., multiple sclerosis (MS). Most human ERVs integrated in our genome are not competent to replicate and these sequences are presumably silent.
Christine Brütting, Christine Brütting, Harini Narasimhan, Frank Hoffmann, Malte E. Kornhuber, Martin S. Staege, Alexander Emmer   +6 more
doaj   +1 more source

Human Endogenous Retrovirus-like Sequences

, 1989
One of the most salient features of the replication strategy used by retroviruses is the transcription of the retroviral (RNA) genome into DNA followed by integration of this DNA product into the host cell genome. The integrated viral DNA copy, termed “provirus”, can then serve as a template for the synthesis of further infectious virus particles ...
Brack-Werner, R., Leib-Mösch, C., Werner, T., Erfle, V.F., Hehlmann, R.   +4 more
openaire   +3 more sources

Genomic Flexibility of Human Endogenous Retrovirus Type K [PDF]

Journal of Virology, 2013
ABSTRACT Human endogenous retrovirus type K (HERV-K) proviruses are scattered throughout the human genome, but as no infectious HERV-K virus has been detected to date, the mechanism by which these viruses replicated and populated the genome remains unresolved.
Dube, Derek, Contreras-Galindo, Rafael, He, Shirley, King, Steven, Gonzalez-Hernandez, Marta, Gitlin, Scott, Kaplan, Mark, Markovitz, David   +7 more
openaire   +3 more sources

Endogenous retrovirus HERVH-derived lncRNA UCA1 controls human trophoblast development. [PDF]

Proc Natl Acad Sci U S A
Kong X, Li R, Chen M, Zheng R, Wang J, Sun C, Qu Y.   +6 more
europepmc   +2 more sources

Arc – An endogenous neuronal retrovirus?

Seminars in Cell & Developmental Biology, 2018
The neuronal gene Arc is essential for long-lasting information storage in the mammalian brain and has been implicated in various neurological disorders. However, little is known about Arc's evolutionary origins. Recent studies suggest that mammalian Arc originated from a vertebrate lineage of Ty3/gypsy retrotransposons, which are also ancestral to ...
openaire   +3 more sources

Suppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development

Nature Communications
The development of functional neurons is a complex orchestration of multiple signaling pathways controlling cell proliferation and differentiation. Because the balance of antioxidants is important for neuronal survival and development, we hypothesized ...
Juliane Tschuck, Vidya Padmanabhan Nair, Ana Galhoz, Carole Zaratiegui, Hin-Man Tai, Gabriele Ciceri, Ina Rothenaigner, Jason Tchieu, Brent R. Stockwell, Lorenz Studer, Daphne S. Cabianca, Michael P. Menden, Michelle Vincendeau, Kamyar Hadian   +13 more
doaj   +1 more source

Evaluation of the Broad-Range PCR-Electrospray Ionization Mass Spectrometry (PCR/ESI-MS) System and Virus Microarrays for Virus Detection

Viruses, 2014
Advanced nucleic acid-based technologies are powerful research tools for novel virus discovery but need to be standardized for broader applications such as virus detection in biological products and clinical samples.
Lanyn P. Taliaferro, Teresa A. Galvin, Hailun Ma, Syed Shaheduzzaman, Dhanya K. Williams, Dustin R. Glasner, Arifa S. Khan   +6 more
doaj   +1 more source