Results 31 to 40 of about 36,840 (231)

Novel Endogenous Retrovirus in Rabbits Previously Reported as Human Retrovirus 5 [PDF]

Journal of Virology, 2002
ABSTRACT Human retrovirus 5 (HRV-5) represented a fragment of a novel retrovirus sequence identified in human RNA and DNA preparations. In this study, the genome of HRV-5 was cloned and sequenced and integration sites were analyzed. Using PCR and Southern hybridization, we showed that HRV-5 is not integrated into human DNA.
Cécile Voisset, Robin A. Weiss, Patrick J Venables, David J. Griffiths   +3 more
openaire   +3 more sources

Pluripotency and the endogenous retrovirus HERVH: Conflict or serendipity? [PDF]

BioEssays, 2015
Remnants of ancient retroviral infections during evolution litter all mammalian genomes. In modern humans, such endogenous retroviral (ERV) sequences comprise at least 8% of the genome. While ERVs and other types of transposable elements undoubtedly contribute to the genomic “junk yard”, functions for some ERV sequences have been demonstrated, with ...
Zsuzsanna Izsvák, Jichang Wang, Manvendra Singh, Dixie L. Mager, Laurence D. Hurst   +4 more
openaire   +3 more sources

Investigation of Endogenous Retrovirus Sequences in the Neighborhood of Genes Up-regulated in a Neuroblastoma Model after Treatment with Hypoxia-Mimetic Cobalt Chloride

Frontiers in Microbiology, 2018
Human endogenous retroviruses (ERVs) have been found to be associated with different diseases, e.g., multiple sclerosis (MS). Most human ERVs integrated in our genome are not competent to replicate and these sequences are presumably silent.
Christine Brütting, Christine Brütting, Harini Narasimhan, Frank Hoffmann, Malte E. Kornhuber, Martin S. Staege, Alexander Emmer   +6 more
doaj   +1 more source

Arc – An endogenous neuronal retrovirus?

Seminars in Cell & Developmental Biology, 2018
The neuronal gene Arc is essential for long-lasting information storage in the mammalian brain and has been implicated in various neurological disorders. However, little is known about Arc's evolutionary origins. Recent studies suggest that mammalian Arc originated from a vertebrate lineage of Ty3/gypsy retrotransposons, which are also ancestral to ...
openaire   +4 more sources

Cooccurrences of Putative Endogenous Retrovirus-Associated Diseases [PDF]

BioMed Research International, 2017
At least 8% of the human genome is composed of endogenous retrovirus (ERV) sequences. ERVs play a role in placental morphogenesis and can sometimes protect the host against exogenous viruses. On the other hand, ERV reactivation has been found to be associated with different diseases, for example, multiple sclerosis (MS), schizophrenia, type 1 diabetes ...
Christine Brütting, Alexander Emmer, Malte E. Kornhuber, Martin S. Staege   +3 more
openaire   +3 more sources

Human Endogenous Retrovirus: Their Relationship with Hematological Diseases [PDF]

Journal of Leukemia, 2016
Human endogenous retrovirus (HERVs) integrated in the human genome millions of years ago and became a stable part of the inherited genetic material. Most of these HERVs are dysfunctional due to numerous mutations and thus making it impossible to generate a full, infectious retrovirus particle from a single genetic locus.
Fischer Alpuin, Sabrina Carla, Echeverría Chagas, Natalia, Cristina, Juan, Moreno Karlen, María del Pilar   +3 more
openaire   +3 more sources

Human endogenous retroviruses and autism spectrum disorder: Brief review of recent literature

European Psychiatry, 2023
Introduction Human endogenous retroviruses (HERVs) are genetic elements resulting from ancestral infection of germline cells. HERVs have been associated with multiple complex disorders, including neurodevelopment disorders, namely autism spectrum ...
R. Mota Freitas, D. Reis Gomes, F. Silveira   +2 more
doaj   +1 more source

Evaluation of the Broad-Range PCR-Electrospray Ionization Mass Spectrometry (PCR/ESI-MS) System and Virus Microarrays for Virus Detection

Viruses, 2014
Advanced nucleic acid-based technologies are powerful research tools for novel virus discovery but need to be standardized for broader applications such as virus detection in biological products and clinical samples.
Lanyn P. Taliaferro, Teresa A. Galvin, Hailun Ma, Syed Shaheduzzaman, Dhanya K. Williams, Dustin R. Glasner, Arifa S. Khan   +6 more
doaj   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Suppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development

Nature Communications
The development of functional neurons is a complex orchestration of multiple signaling pathways controlling cell proliferation and differentiation. Because the balance of antioxidants is important for neuronal survival and development, we hypothesized ...
Juliane Tschuck, Vidya Padmanabhan Nair, Ana Galhoz, Carole Zaratiegui, Hin-Man Tai, Gabriele Ciceri, Ina Rothenaigner, Jason Tchieu, Brent R. Stockwell, Lorenz Studer, Daphne S. Cabianca, Michael P. Menden, Michelle Vincendeau, Kamyar Hadian   +13 more
doaj   +1 more source