Results 31 to 40 of about 603,777 (298)

Demystified . . . Human endogenous retroviruses [PDF]

Molecular Pathology, 2003
Human endogenous retroviruses (HERVs) are a family of viruses within our genome with similarities to present day exogenous retroviruses. HERVs have been inherited by successive generations and it is possible that some have conferred biological benefits. However, several HERVs have been implicated in certain cancers and autoimmune diseases. This article
Nelson, Paul N., Carnegie, P.R., Martin, Jan H., Ejtehadi, H. Davari, Hooley, Paul, Roden, Denise A., Rowland-Jones, S., Warren, Phil, Astley, S.J., Murray, Paul G.   +9 more
openaire   +3 more sources

Identification of shared tumor epitopes from endogenous retroviruses inducing high-avidity cytotoxic T cells for cancer immunotherapy

Science Advances, 2022
Human endogenous retroviruses (HERVs) represent 8% of the human genome. HERV products may represent tumor antigens relevant for cancer immunotherapy.
Paola Bonaventura, V. Alcazer, Virginie Mutez, L. Tonon, Juliette Martin, N. Chuvin, Emilie Michel, Rasha E. Boulos, Y. Estornes, J. Valladeau-Guilemond, Alain Viari, Qing Wang, Christophe Caux, S. Depil   +13 more
semanticscholar   +1 more source

Induced prion protein controls immune-activated retroviruses in the mouse spleen. [PDF]

PLoS ONE, 2007
The prion protein (PrP) is crucially involved in transmissible spongiform encephalopathies (TSE), but neither its exact role in disease nor its physiological function are known.
Marius Lötscher, Mike Recher, Karl S Lang, Alexander Navarini, Lukas Hunziker, Roger Santimaria, Markus Glatzel, Petra Schwarz, Jürg Böni, Rolf M Zinkernagel   +9 more
doaj   +1 more source

The Relationship of the Mechanisms of the Pathogenesis of Multiple Sclerosis and the Expression of Endogenous Retroviruses

Biology, 2020
Two human endogenous retroviruses of the HERV-W family can act as cofactors triggering multiple sclerosis (MS): MS-associated retrovirus (MSRV) and ERVWE1.
Vera R. Lezhnyova, Ekaterina V. Martynova, Timur I. Khaiboullin, Richard A. Urbanowicz, Svetlana F. Khaiboullina, Albert A. Rizvanov   +5 more
doaj   +1 more source

Expression signature of human endogenous retroviruses in chronic lymphocytic leukemia

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance This paper describes the characterization of endogenous retroviruses in chronic lymphocytic leukemia (CLL), the most common leukemia in the Western world. In this study, we identified a signature of dysregulated human endogenous retroviruses
A. L. Ferlita, G. Nigita, L. Tsyba, Alexey Palamarchuk, S. Alaimo, Alfredo Pulvirenti, Veronica Balatti, L. Rassenti, Philip N. Tsichlis, T. Kipps, Y. Pekarsky, Carlo M. Croce   +11 more
semanticscholar   +1 more source

Endogenous retroviruses in the origins and treatment of cancer

Genome Biology, 2021
Endogenous retroviruses (ERVs) are emerging as promising therapeutic targets in cancer. As remnants of ancient retroviral infections, ERV-derived regulatory elements coordinate expression from gene networks, including those underpinning embryogenesis and
N. Jansz, G. Faulkner
semanticscholar   +1 more source

The extraordinary evolutionary history of the reticuloendotheliosis viruses [PDF]

, 2013
The reticuloendotheliosis viruses (REVs) comprise several closely related amphotropic retroviruses isolated from birds. These viruses exhibit several highly unusual characteristics that have not so far been adequately explained, including their extremely
A Katzourakis, A Katzourakis, A Stamatakis, AC van der Kuyl, AD Yoder, AL Hughes, AM Awad, AM Fadly, Anna Maria Niewiadomska, Bill Sugden, BR Burmester, C Feschotte, C Hertig, CG Ludford, CG Ludford, CN Dren, CN Dren, CN Dren, CR Parrish, CY Kang, CY Lin, DC Nickle, DH Huson, DH Ley, DJ McGeoch, DS Arathy, DW Trampel, E Prukner-Radovcic, EH Dearborn, F Abascal, F Rodriguez, FR Robinson, H Koyama, HC Carlson, HG Purchase, HM Koo, I Davidson, IS Diallo, IS Diallo, J Hanson, J Li, J Martin, JJ Solomon, JP Stoye, JP Vanderberg, JS McDougall, K Nyakatura, KA Schat, KM Moore, LA Terzian, LE Hayes, LJ Yu, LT Coggeshall, M Barbacid, M Garcia, MJ Peterson, MK Cook, ML Drew, MR Patel, MW Dimmic, MX Motha, N Ratnamohan, N Yuasa, P Singh, PE Miller, PS Paul, PS Sarma, Q Liu, R Crespo, R Gifford, R Isfort, RA Weiss, RB Franklin, RB Franklin, RJ Isfort, RL Witter, RL Witter, RL Witter, RM Corwin, Robert J. Gifford, SB Hitchner, SK Biswas, SL Kosakovsky Pond, T Barbosa, T Tadese, TJ Kim, TM Grimes, VN Kewalramani, W Trager, WG Conway, WH Cheng, Y Wang, Z Cheng, Z Cui, Z Yang, É Brumpt   +95 more
core   +3 more sources

Human endogenous retroviruses and the inflammatory response: A vicious circle associated with health and illness

Frontiers in Immunology, 2022
Human Endogenous Retroviruses (HERVs) are derived from ancient exogenous retroviral infections that have infected our ancestors’ germline cells, underwent endogenization process, and were passed throughout the generations by retrotransposition and ...
Sara Coelho Rangel, Michelly Damasceno da Silva, Amanda Lopes da Silva, J. M. B. D. dos Santos, L. M. Neves, A. Pedrosa, F. M. Rodrigues, C. S. Trettel, G. Furtado, M. P. de Barros, A. Bachi, C. Romano, L. H. S. Nali   +12 more
semanticscholar   +1 more source

TERT activates endogenous retroviruses to promote an immunosuppressive tumour microenvironment

EMBO Reports, 2022
Telomerase plays a pivotal role in tumorigenesis by both telomere‐dependent and telomere‐independent activities, although the underlying mechanisms are not completely understood.
Jian Mao, Qian Zhang, Yaxiang Wang, Zhuang Yang, Lu Xu, Xiaohe Ma, D. Guan, Junzhi Zhou, Jiang Liu, Xiaoying Wu, Qi’an Liang, Miao Wang, Y. Cong   +12 more
semanticscholar   +1 more source

Highly Variable Genomic Landscape of Endogenous Retroviruses in the C57BL/6J Inbred Strain, Depending on Individual Mouse, Gender, Organ Type, and Organ Location. [PDF]

, 2017
Transposable repetitive elements, named the "TREome," represent ~40% of the mouse genome. We postulate that the germ line genome undergoes temporal and spatial diversification into somatic genomes in conjunction with the TREome activity.
Cho, Kiho, Greenhalgh, David, Lee, Kang-Hoon, Lim, Debora   +3 more
core   +2 more sources