Results 41 to 50 of about 445,067 (194)

Endogenous Retroviruses in Nervous System Disorders

Pharmaceuticals, 2021
Human endogenous retroviruses (HERV) have been implicated in the pathogenesis of several nervous system disorders including multiple sclerosis and amyotrophic lateral sclerosis.
Victoria Gröger, Alexander Emmer, Martin S. Staege, Holger Cynis   +3 more
doaj   +1 more source

Distribution of Endogenous Retroviruses in Crocodilians [PDF]

Journal of Virology, 2009
ABSTRACT Knowledge of endogenous retroviruses (ERVs) in crocodilians (Crocodylia) is limited, and their distribution among extant species is unclear. Here we analyzed the phylogenetic relationships of these retroelements in 20 species of crocodilians by studying the pro-pol gene.
Weerachai, Jaratlerdsiri, Clara J, Rodríguez-Zárate, Sally R, Isberg, Chandramaya Siska, Damayanti, Lee G, Miles, Nantarika, Chansue, Chris, Moran, Lorna, Melville, Jaime, Gongora   +8 more
openaire   +2 more sources

Cell-Int: a cell–cell interaction assay to identify native membrane protein interactions

Life Science Alliance
A cell interaction assay to study membrane protein interactions in quasi-physiological settings, with multiple applications, from deciphering interaction networks to assessing therapeutic molecules.
Thibaud Aymoz-Bressot, Marie Canis, Florian Meurisse, Anne Wijkhuisen, Benoit Favier, Guillaume Mousseau, Anne Dupressoir, Thierry Heidmann, Agathe Bacquin   +8 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Avian Endogenous Retroviruses

Folia Biologica, 2003
Recent data about the diversity of AER, their structure, expression and possible ways of evolution are summarized and analysed in the present review. Additionally, the role of endogenous retroviruses in ontogenesis and pathology is discussed.
openaire   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Human endogenous retroviruses and autism spectrum disorder: Brief review of recent literature

European Psychiatry, 2023
Introduction Human endogenous retroviruses (HERVs) are genetic elements resulting from ancestral infection of germline cells. HERVs have been associated with multiple complex disorders, including neurodevelopment disorders, namely autism spectrum ...
R. Mota Freitas, D. Reis Gomes, F. Silveira   +2 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Emv2, the only endogenous ecotropic murine leukemia virus of C57BL/6J mice

Retrovirology, 2012
With the proliferation of sequence data, great challenges are posed in the correct annotation of endogenous retroviruses, which together comprise up to ten per cent of the genomes of many organisms.
Young George R, Kassiotis George, Stoye Jonathan P   +2 more
doaj   +1 more source