Results 21 to 30 of about 52,210 (255)

A recombinant measles virus vaccine strongly reduces SHIV viremia and virus reservoir establishment in macaques

npj Vaccines, 2021
Replicative vectors derived from live-attenuated measles virus (MV) carrying additional non-measles vaccine antigens have long demonstrated safety and immunogenicity in humans despite pre-existing immunity to measles.
Patrycja Nzounza, Grégoire Martin, Nathalie Dereuddre-Bosquet, Valérie Najburg, Leslie Gosse, Claude Ruffié, Chantal Combredet, Caroline Petitdemange, Sylvie Souquère, Géraldine Schlecht-Louf, Christiane Moog, Gérard Pierron, Roger Le Grand, Thierry Heidmann, Frédéric Tangy   +14 more
doaj   +1 more source

Demystified . . . Human endogenous retroviruses [PDF]

Molecular Pathology, 2003
Human endogenous retroviruses (HERVs) are a family of viruses within our genome with similarities to present day exogenous retroviruses. HERVs have been inherited by successive generations and it is possible that some have conferred biological benefits. However, several HERVs have been implicated in certain cancers and autoimmune diseases. This article
Nelson, Paul N., Carnegie, P.R., Martin, Jan H., Ejtehadi, H. Davari, Hooley, Paul, Roden, Denise A., Rowland-Jones, S., Warren, Phil, Astley, S.J., Murray, Paul G.   +9 more
openaire   +3 more sources

Larger mammalian body size leads to lower retroviral activity [PDF]

, 2014
Retroviruses have been infecting mammals for at least 100 million years, leaving descendants in host genomes known as endogenous retroviruses (ERVs). The abundance of ERVs is partly determined by their mode of replication, but it has also been suggested ...
Belshaw, Robert, Gifford, Robert, Gupta, Sunetra, Katzourakis, Aris, Lim, Aaron G., Magiorkinis, Gkikas   +5 more
core   +7 more sources

Reactivated endogenous retroviruses promote protein aggregate spreading

Nature Communications, 2023
Prion-like spreading of protein misfolding is a characteristic of neurodegenerative diseases, but the exact mechanisms of intercellular protein aggregate dissemination remain unresolved.
Shu Liu, Stefanie-Elisabeth Heumüller, André Hossinger, Stephan A. Müller, Oleksandra Buravlova, Stefan F. Lichtenthaler, Philip Denner, Ina M. Vorberg   +7 more
doaj   +1 more source

Induced prion protein controls immune-activated retroviruses in the mouse spleen. [PDF]

PLoS ONE, 2007
The prion protein (PrP) is crucially involved in transmissible spongiform encephalopathies (TSE), but neither its exact role in disease nor its physiological function are known.
Marius Lötscher, Mike Recher, Karl S Lang, Alexander Navarini, Lukas Hunziker, Roger Santimaria, Markus Glatzel, Petra Schwarz, Jürg Böni, Rolf M Zinkernagel   +9 more
doaj   +1 more source

Evolutionary analysis of endogenous intronic retroviruses in primates reveals an enrichment in transcription binding sites associated with key regulatory processes [PDF]

PeerJ, 2022
Background Endogenous retroviruses (ERVs) are the result of the integration of retroviruses into host DNA following germline infection. Endogenous retroviruses are made up of three main genes: gag, pol, and env, each of which encodes viral proteins that ...
Melissa Calero-Layana, Carmen López-Cruz, Agustín Ocaña, Eduardo Tejera, Vinicio Armijos-Jaramillo   +4 more
doaj   +2 more sources

The Relationship of the Mechanisms of the Pathogenesis of Multiple Sclerosis and the Expression of Endogenous Retroviruses

Biology, 2020
Two human endogenous retroviruses of the HERV-W family can act as cofactors triggering multiple sclerosis (MS): MS-associated retrovirus (MSRV) and ERVWE1.
Vera R. Lezhnyova, Ekaterina V. Martynova, Timur I. Khaiboullin, Richard A. Urbanowicz, Svetlana F. Khaiboullina, Albert A. Rizvanov   +5 more
doaj   +1 more source

Increased levels of endogenous retroviruses trigger fibroinflammation and play a role in kidney disease development

Nature Communications, 2023
The contribution of transposable elements and endogenous retroviruses to renal fibroinflammation is currently unknown. Here, the authors comprehensively profile the expression of transposable elements and endogenous retroviruses (ERVs) in kidneys of ...
Poonam Dhillon, Kelly Ann Mulholland, Hailong Hu, Jihwan Park, Xin Sheng, Amin Abedini, Hongbo Liu, Allison Vassalotti, Junnan Wu, Katalin Susztak   +9 more
doaj   +1 more source

Distribution, diversity and evolution of endogenous retroviruses in perissodactyl genomes [PDF]

, 2018
The evolution of mammalian genomes has been shaped by interactions with endogenous retroviruses (ERVs). In this study, we investigated the distribution and diversity of ERVs in the mammalian order Perissodactyla, with a view to understanding their impact
Gifford, Robert, Murcia, Pablo Ramiro, Zhu, Henan   +2 more
core   +1 more source

The extraordinary evolutionary history of the reticuloendotheliosis viruses [PDF]

, 2013
The reticuloendotheliosis viruses (REVs) comprise several closely related amphotropic retroviruses isolated from birds. These viruses exhibit several highly unusual characteristics that have not so far been adequately explained, including their extremely
A Katzourakis, A Katzourakis, A Stamatakis, AC van der Kuyl, AD Yoder, AL Hughes, AM Awad, AM Fadly, Anna Maria Niewiadomska, Bill Sugden, BR Burmester, C Feschotte, C Hertig, CG Ludford, CG Ludford, CN Dren, CN Dren, CN Dren, CR Parrish, CY Kang, CY Lin, DC Nickle, DH Huson, DH Ley, DJ McGeoch, DS Arathy, DW Trampel, E Prukner-Radovcic, EH Dearborn, F Abascal, F Rodriguez, FR Robinson, H Koyama, HC Carlson, HG Purchase, HM Koo, I Davidson, IS Diallo, IS Diallo, J Hanson, J Li, J Martin, JJ Solomon, JP Stoye, JP Vanderberg, JS McDougall, K Nyakatura, KA Schat, KM Moore, LA Terzian, LE Hayes, LJ Yu, LT Coggeshall, M Barbacid, M Garcia, MJ Peterson, MK Cook, ML Drew, MR Patel, MW Dimmic, MX Motha, N Ratnamohan, N Yuasa, P Singh, PE Miller, PS Paul, PS Sarma, Q Liu, R Crespo, R Gifford, R Isfort, RA Weiss, RB Franklin, RB Franklin, RJ Isfort, RL Witter, RL Witter, RL Witter, RM Corwin, Robert J. Gifford, SB Hitchner, SK Biswas, SL Kosakovsky Pond, T Barbosa, T Tadese, TJ Kim, TM Grimes, VN Kewalramani, W Trager, WG Conway, WH Cheng, Y Wang, Z Cheng, Z Cui, Z Yang, É Brumpt   +95 more
core   +3 more sources