Results 11 to 20 of about 445,067 (194)

Demystified . . . Human endogenous retroviruses [PDF]

Molecular Pathology, 2003
Human endogenous retroviruses (HERVs) are a family of viruses within our genome with similarities to present day exogenous retroviruses. HERVs have been inherited by successive generations and it is possible that some have conferred biological benefits. However, several HERVs have been implicated in certain cancers and autoimmune diseases. This article
Nelson, Paul N., Carnegie, P.R., Martin, Jan H., Ejtehadi, H. Davari, Hooley, Paul, Roden, Denise A., Rowland-Jones, S., Warren, Phil, Astley, S.J., Murray, Paul G.   +9 more
core   +9 more sources

A paradigm for virus-host coevolution: sequential counter-adaptations between endogenous and exogenous retroviruses. [PDF]

PLoS Pathogens, 2007
Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections of the host germline transmitted vertically from generation to generation. It is hypothesized that some ERVs are used by the host as restriction factors to block the infection ...
Frederick Arnaud, Marco Caporale, Mariana Varela, Roman Biek, Bernardo Chessa, Alberto Alberti, Matthew Golder, Manuela Mura, Ya-Ping Zhang, Li Yu, Filipe Pereira, James C Demartini, Kreg Leymaster, Thomas E Spencer, Massimo Palmarini   +14 more
doaj   +2 more sources

Reactivated endogenous retroviruses promote protein aggregate spreading [PDF]

Nature Communications, 2023
Prion-like spreading of protein misfolding is a characteristic of neurodegenerative diseases, but the exact mechanisms of intercellular protein aggregate dissemination remain unresolved.
Shu Liu, Stefanie-Elisabeth Heumüller, André Hossinger, Stephan A. Müller, Oleksandra Buravlova, Stefan F. Lichtenthaler, Philip Denner, Ina M. Vorberg   +7 more
doaj   +2 more sources

Human endogenous retroviruses and cancer

Cancer Biology & Medicine, 2016
Human endogenous retroviruses (HERVs) are retroviruses that infected human genome millions of years ago and have persisted throughout human evolution.
María Gonzalez-Cao, Paola Iduma, Niki Karachaliou, Mariacarmela Santarpia, Julià Blanco, Rafael Rosell   +5 more
doaj   +4 more sources

piRNA Defense Against Endogenous Retroviruses [PDF]

Viruses
Infection by retroviruses and the mobilization of transposable elements cause DNA damage that can be catastrophic for a cell. If the cell survives, the mutations generated by retrotransposition may confer a selective advantage, although, more commonly ...
Milky Abajorga, Leonid Yurkovetskiy, Jeremy Luban   +2 more
doaj   +2 more sources

RETRACTED: Iftikhar et al. Endogenous Retroviruses as Regulators of Innate Immune Signaling and Inflammation. Viruses 2026, 18, 289 [PDF]

Viruses
Viruses retracts the review article titled “Endogenous Retroviruses as Regulators of Innate Immune Signaling and Inflammation” [...]
Muhammad Iftikhar, Xinyan Wang, Qiangzhou Wang, Jiaxing Wang, Lihong Gu, Shihao Chen   +5 more
doaj   +2 more sources

Human endogenous retroviruses and ageing [PDF]

Immunity & Ageing, 2021
Mikko Hurme, Graham Pawelec
doaj   +3 more sources

Human endogenous retroviruses and exogenous viral infections

Frontiers in Cellular and Infection Microbiology
The human genome harbors many endogenous retroviral elements, known as human endogenous retroviruses (HERVs), which have been integrated into the genome during evolution due to infections by exogenous retroviruses.
Chenxuan Bao, Qing Gao, Huayuan Xiang, Yuxuan Shen, Qiaoqiao Chen, Qianqian Gao, Yuanfei Cao, Mengyu Zhang, Wenyuan He, Lingxiang Mao   +9 more
exaly   +3 more sources

Evolution and phylogeny of insect endogenous retroviruses [PDF]

BMC Evolutionary Biology, 2001
Background The genome of invertebrates is rich in retroelements which are structurally reminiscent of the retroviruses of vertebrates. Those containing three open reading frames (ORFs), including an env-like gene, may well be considered as endogenous ...
Pélisson Alain, Terzian Christophe, Bucheton Alain   +2 more
doaj   +2 more sources

Antibodies against endogenous retroviruses. [PDF]

Immunol Rev
SummaryThe human genome harbors hundreds of thousands of integrations of ancient retroviruses, amassed over millions of years of evolution. To reduce further amplification in the genome, the host prevents transcription of these now endogenous retroviruses (ERVs) through epigenetic repression and, with evolutionary time, ERVs are incapacitated by ...
Chisca M, Larouche JD, Xing Q, Kassiotis G.   +3 more
europepmc   +3 more sources