Results 61 to 70 of about 52,210 (255)

Vaccination directed against the human endogenous retrovirus-K envelope protein inhibits tumor growth in a murine model system [PDF]

, 2013
Human endogenous retrovirus (HERV) genomes are chromosomally integrated in all cells of an individual. They are normally transcriptionally silenced and transmitted only vertically. Enhanced expression of HERV-K accompanied by the emergence of anti-HERV-K-
Büchner, Sarah M., Fischer, Katrin, Kraus, Benjamin, Löwer, Roswitha, Schnierle, Barbara S., Sliva, Katja, Wels, Winfried S.   +6 more
core   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

A novel class III endogenous retrovirus with a class I envelope gene in African frogs with an intact genome and developmentally regulated transcripts in Xenopus tropicalis

Retrovirology, 2021
Background Retroviruses exist as exogenous infectious agents and as endogenous retroviruses (ERVs) integrated into host chromosomes. Such endogenous retroviruses (ERVs) are grouped into three classes roughly corresponding to the seven genera of ...
Venkat R. K. Yedavalli, Akash Patil, Janay Parrish, Christine A. Kozak   +3 more
doaj   +1 more source

Human endogenous retroviruses in development and disease

Computational and Structural Biotechnology Journal, 2021
Human endogenous retroviruses (HERVs) represent ∼8% of human genome, deriving from exogenous retroviral infections of germ line cells occurred millions of years ago and being inherited by the offspring in a Mendelian fashion. Most of HERVs are nonprotein-
Jian Mao, Qian Zhang, Yu-Sheng Cong
doaj   +1 more source

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, EarlyView.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

Remnants of an ancient deltaretrovirus in the genomes of horseshoe aats (Rhinolophidae) [PDF]

, 2018
Endogenous retrovirus (ERV) sequences provide a rich source of information about the long-term interactions between retroviruses and their hosts. However, most ERVs are derived from a subset of retrovirus groups, while ERVs derived from certain other ...
Benda, Petr, Elleder, Daniel, Farkašová, Helena, Gifford, Robert J., Görföl, Tamás, Hron, Tomáš, Hulva, Pavel, Pačes, Jan   +7 more
core   +5 more sources

Epigenetic motifs distinguishing endogenous from exogenous retroviral integrants

Journal of Virology
Retroviruses are subject to epigenetic regulation by the host genome after integrating, similar to vertebrate genes. However, their patterns of integration, and therefore their likely epigenetic regulation, differ between genera.
Sarah LaMere, Hanbei Xiong, Wei Wang, Brian LaMere, Niema Moshiri   +4 more
doaj   +1 more source

Endogenous Viral Etiology of Prion Diseases [PDF]

, 2009
Transmissible spongiform encephalopathies (TSEs), or prion diseases, are a group of incurable neurodegenerative disorders, including Kuru and Creutzfeldt-Jakob disease in humans, “mad cow” disease in cattle, and scrapie in sheep. This paper
Claudiu I. Bandea
core   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Evidence for restriction of ancient primate gammaretroviruses by APOBEC3 but not TRIM5alpha proteins.

PLoS Pathogens, 2008
Because of evolutionary pressures imposed through episodic colonization by retroviruses, many mammals express factors, such as TRIM5alpha and APOBEC3 proteins, that directly restrict retroviral replication.
David Perez-Caballero, Steven J Soll, Paul D Bieniasz   +2 more
doaj   +1 more source