Results 41 to 50 of about 603,777 (298)

Human endogenous retroviruses in cancer: Oncogenesis mechanisms and clinical implications

Journal of Medical Virology, 2022
Human Endogenous Retroviruses (HERVs) are viral sequences integrated into the human genome, resulting from the infection of human germ‐line cells by ancient exogenous retroviruses.
Konstantina Kitsou, P. Lagiou, G. Magiorkinis   +2 more
semanticscholar   +1 more source

Regulation of human trophoblast gene expression by endogenous retroviruses

bioRxiv, 2022
Here the authors investigate the contribution of transposable elements to regulation of gene expression in human trophoblasts. Amongst other examples, they identify an LTR10A element with potential implications for preeclampsia.
J. Frost, Samuele M. Amante, Hiroaki Okae, E. Jones, B. Ashley, Rohan M. Lewis, J. Cleal, M. Caley, T. Arima, T. Maffucci, M. Branco   +10 more
semanticscholar   +1 more source

Mammalian Endogenous Retroviruses

Microbiology Spectrum, 2015
ABSTRACT Over 40% of mammalian genomes comprise the products of reverse transcription. Among such retrotransposed sequences are those characterized by the presence of long terminal repeats (LTRs), including the endogenous retroviruses (ERVs), which are inherited genetic elements closely resembling the proviruses formed following exogenous ...
Dixie L, Mager, Jonathan P, Stoye
openaire   +2 more sources

Antibodies against endogenous retroviruses. [PDF]

Immunol Rev
SummaryThe human genome harbors hundreds of thousands of integrations of ancient retroviruses, amassed over millions of years of evolution. To reduce further amplification in the genome, the host prevents transcription of these now endogenous retroviruses (ERVs) through epigenetic repression and, with evolutionary time, ERVs are incapacitated by ...
Chisca M, Larouche JD, Xing Q, Kassiotis G.   +3 more
europepmc   +3 more sources

Vaccination directed against the human endogenous retrovirus-K envelope protein inhibits tumor growth in a murine model system [PDF]

, 2013
Human endogenous retrovirus (HERV) genomes are chromosomally integrated in all cells of an individual. They are normally transcriptionally silenced and transmitted only vertically. Enhanced expression of HERV-K accompanied by the emergence of anti-HERV-K-
Büchner, Sarah M., Fischer, Katrin, Kraus, Benjamin, Löwer, Roswitha, Schnierle, Barbara S., Sliva, Katja, Wels, Winfried S.   +6 more
core   +2 more sources

SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells

Nature Communications, 2019
Endogenous retroviruses (ERVs) can confer benefits to their host but present a threat to genome integrity if not regulated correctly. Here we identify the SWI/SNF-like remodeler SMARCAD1 as a key factor in the control of ERVs in embryonic stem cells ...
Parysatis Sachs, D. Ding, Philipp Bergmaier, Boris Lamp, Christina Schlagheck, F. Finkernagel, Andrea Nist, T. Stiewe, J. E. Mermoud   +8 more
semanticscholar   +1 more source

Hijacking of transcriptional condensates by endogenous retroviruses

Nature Genetics, 2021
Most endogenous retroviruses (ERVs) in mammals are incapable of retrotransposition; therefore, why ERV derepression is associated with lethality during early development has been a mystery.
Vahid Asimi, Abhishek Sampath Kumar, H. Niskanen, Christina Riemenschneider, Sara Hetzel, Julian Naderi, Nina Fasching, Niko Popitsch, Manyu Du, H. Kretzmer, Zachary D. Smith, Raha Weigert, Maria Walther, S. Mamde, D. Meierhofer, L. Wittler, René Buschow, B. Timmermann, I. Cissé, Stefan L Ameres, A. Meissner, Denes Hnisz   +21 more
semanticscholar   +1 more source

Spatiotemporal variations in retrovirus-host interactions among Darwin’s finches

Nature Communications, 2022
Endogenous retroviruses (ERV) are inherited remains of retroviruses that have colonized host genomes during evolution. Here the authors observe considerable species-specific ERV variation among Darwin’s finches, reflecting historic retrovirus-host ...
Jason Hill, Mette Lillie, Mats E. Pettersson, Carl-Johan Rubin, B. Rosemary Grant, Peter R. Grant, Leif Andersson, Patric Jern   +7 more
doaj   +1 more source

Characterization of porcine endogenous retrovirus expression in neonatal and adult pig pancreatic islets [PDF]

, 2017
BACKGROUND: Pig islets represent an alternative to the current modes of treatment for patients with diabetes. However, the concerns over pathogen transmission including that of PERV limit their immediate, widespread usage in humans.
Akiyoshi, Bittmann, Claire Crossan, Clemenceau, Clemenceau, Cooper, Denner, Denner, Denner, Dieckhoff, Fishman, Gazda, Guo, Irgang, Kimsa, Korbutt, Linda Scobie, Matsumoto, Mazurek, Moon, Morozov, Mourad, Mueller, Nizar I. Mourad, Patience, Pierre Gianello, Pizzato, Schuurman, Scobie, Spizzo, Sypniewski, Tacke, Tucker, Victoria Cruikshank, Wynyard, Wynyard, Zhang   +36 more
core   +1 more source

Activation of endogenous retroviruses during brain development causes an inflammatory response

EMBO Journal, 2021
Endogenous retroviruses (ERVs) make up a large fraction of mammalian genomes and are thought to contribute to human disease, including brain disorders.
M. Jönsson, R. Garza, Yogita Sharma, Rebecca Petri, Erik Södersten, Jenny G. Johansson, P. Johansson, D. Atacho, Karolina Pircs, Sofia Madsen, David Yudovich, Ramprasad Ramakrishnan, J. Holmberg, Jonas Larsson, P. Jern, Johan Jakobsson   +15 more
semanticscholar   +1 more source