Assessment of porcine endogenous retrovirus transmission across an alginate barrier used for the encapsulation of porcine islets [PDF]
, 2018 BACKGROUND: Subcutaneous implantation of a macroencapsulated patch containing human allogenic islets has been successfully used to alleviate type 1 diabetes mellitus (T1DM) in a human recipient without the need for immunosuppression.
Crossan, Claire +4 more
core +1 more source
Human endogenous retroviruses and autism spectrum disorder: Brief review of recent literature
European Psychiatry, 2023 Introduction Human endogenous retroviruses (HERVs) are genetic elements resulting from ancestral infection of germline cells. HERVs have been associated with multiple complex disorders, including neurodevelopment disorders, namely autism spectrum ...
R. Mota Freitas +2 more
doaj +1 more source
Force for ancient and recent life: viral and stem-loop RNA consortia promote life. [PDF]
, 2014 Lytic viruses were thought to kill the most numerous host (i.e., kill the winner). But persisting viruses/defectives can also protect against viruses, especially in a ubiquitous virosphere. In 1991, Yarmolinsky et al.
Villarreal, Luis P
core +1 more source
Emerging roles for endogenous retroviruses in immune epigenetic regulation *
Immunological Reviews, 2021 In recent years, there has been significant progress toward understanding the transcriptional networks underlying mammalian immune responses, fueled by advances in regulatory genomic technologies.
Carmen A. Buttler, Edward B. Chuong
semanticscholar +1 more source
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Are dogs not susceptible to retroviral infections?
Animal Diseases, 2023 Retroviruses have been proven to cause infections and diseases in a series of mammalian hosts but not in dogs. Then, this letter discussed the dog susceptibility to retrovirus infection, encompassing arguments to understand why dogs may have not been ...
Jorge Casseb +2 more
doaj +1 more source
Truncation of TRIM5 in the Feliformia explains the absence of retroviral restriction in cells of the domestic cat [PDF]
, 2009 TRIM5[alpha] mediates a potent retroviral restriction phenotype in diverse mammalian species. Here, we identify a TRIM5 transcript in cat cells with a truncated B30.2 capsid binding domain and ablated restrictive function which, remarkably, is conserved ...
Hosie, Margaret J. +5 more
core +2 more sources
Viruses and Endogenous Retroviruses as Roots for Neuroinflammation and Neurodegenerative Diseases
Frontiers in Neuroscience, 2021 Many neurodegenerative diseases are associated with chronic inflammation in the brain and periphery giving rise to a continuous imbalance of immune processes.
Christine Römer
semanticscholar +1 more source
ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication
Advanced Science, EarlyView.During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou +8 more
wiley +1 more source
Retrovirology, 2012 With the proliferation of sequence data, great challenges are posed in the correct annotation of endogenous retroviruses, which together comprise up to ten per cent of the genomes of many organisms.
Young George R +2 more
doaj +1 more source