Results 181 to 190 of about 13,041 (209)

Review: The enigmatic role of endoglin in the placenta

Placenta, 2014
The cellular expression, structure and function of endoglin, and its implication in several vascular disorders remain enigmatic, even 30 years after its discovery. Endoglin (CD105) is a homodimeric glycoprotein (180 kDa) constitutively expressed in the vascular endothelium.
Guohua Xu, Michelle Letarte
exaly   +3 more sources

Endoglin and soluble endoglin in liver sinusoidal endothelial dysfunction in vivo

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Liver sinusoidal endothelial cells (LSECs) play a crucial role in regulating the hepatic function. Endoglin (ENG), a transmembrane glycoprotein, was shown to be related to the development of endothelial dysfunction. In this study, we hypothesized the relationship between changes in ENG expression and markers of liver sinusoidal endothelial dysfunction (
Samira, Eissazadeh, SeyedehNiloufar, Mohammadi, Fatemeh Alaei, Faradonbeh, Jana Urbankova, Rathouska, Ivana, Nemeckova, Katarina, Tripska, Barbora, Vitverova, Ester, Dohnalkova, Martina, Vasinova, Petra, Fikrova, Ivone Cristina Igreja, Sa, Stanislav, Micuda, Petr, Nachtigal   +12 more
openaire   +2 more sources

Expression of endoglin in choroidal neovascularization

Experimental Eye Research, 2004
Endoglin (CD105) is a membrane protein involved in the TGF-beta receptor signalling pathway with predominant expression by proliferating endothelial cells. The aim of this study is to analyze the expression of Endoglin in choroidal neovascularization membranes (CNVM) and to compare it to the overall proliferative status of CNVM.
Grisanti, Salvatore, Canbek, Serap, Kaiserling, Edwin, Adam, Anne, Lafaut, Bart, Gelisken, Faik, Szurman, Peter, Henke-Fahle, Sigrid, Oficjalska-Młyńczak, Jolanta, Bartz-Schmidt, Karl   +9 more
openaire   +2 more sources

Soluble endoglin, hypercholesterolemia and endothelial dysfunction

Atherosclerosis, 2015
A soluble form of endoglin (sEng) is known to be an extracellular domain of the full-length membrane endoglin, which is elevated during various pathological conditions related to vascular endothelium. In the current review, we tried to summarize a possible role of soluble endoglin in cardiovascular pathologies, focusing on its relation to endothelial ...
Jana Rathouska, Katerina Blažičková, Ivana Nemeckova   +2 more
exaly   +3 more sources

Endoglin interacts with VEGFR2 to promote angiogenesis

The FASEB Journal, 2018
ABSTRACT Endoglin, a TGF‐β coreceptor predominantly expressed in endothelial cells, plays an important role in vascular development and tumor‐associated angiogenesis. However, the mechanism by which endoglin regulates angiogenesis, especially during tip cell formation, remains largely unknown.
Hongyu, Tian, Jennifer J, Huang, Christelle, Golzio, Xia, Gao, Melissa, Hector-Greene, Nicholas, Katsanis, Gerard C, Blobe   +6 more
openaire   +2 more sources

Soluble endoglin contributes to the pathogenesis of preeclampsia

Nature Medicine, 2006
Preeclampsia is a pregnancy-specific hypertensive syndrome that causes substantial maternal and fetal morbidity and mortality. Maternal endothelial dysfunction mediated by excess placenta-derived soluble VEGF receptor 1 (sVEGFR1 or sFlt1) is emerging as a prominent component in disease pathogenesis.
Shivalingappa, Venkatesha, Mourad, Toporsian, Chun, Lam, Jun-ichi, Hanai, Tadanori, Mammoto, Yeon M, Kim, Yuval, Bdolah, Kee-Hak, Lim, Hai-Tao, Yuan, Towia A, Libermann, Isaac E, Stillman, Drucilla, Roberts, Patricia A, D'Amore, Franklin H, Epstein, Frank W, Sellke, Roberto, Romero, Vikas P, Sukhatme, Michelle, Letarte, S Ananth, Karumanchi   +18 more
openaire   +2 more sources

Endoglin (CD105) expression in sinonasal polyposis

European Archives of Oto-Rhino-Laryngology, 2015
Despite appropriate surgical therapy, 5-10 % of patients with chronic rhinosinusitis (CRS) and nasal polyps (NP) experience disease recurrences. It has been suggested that angiogenesis may relate to the pathogenesis and prognosis of CRS with NP. Endoglin (CD105) is a component of the receptor complex of transforming growth factor-beta, a pleiotropic ...
OTTAVIANO, GIANCARLO, Cappellesso, R, Mylonakis, I, Lionello, M, Favaretto, N, Giacomelli, L, Spoladore, C, Marchese Ragona, R, Marino, F, STAFFIERI, ALBERTO, MARTINI, ALESSANDRO, MARIONI, GINO   +11 more
openaire   +3 more sources

Defective Angiogenesis in Mice Lacking Endoglin

Science, 1999
Endoglin is a transforming growth factor–β (TGF-β) binding protein expressed on the surface of endothelial cells. Loss-of-function mutations in the human endoglin gene ENG cause hereditary hemorrhagic telangiectasia (HHT1), a disease characterized by vascular malformations.
D Y, Li, L K, Sorensen, B S, Brooke, L D, Urness, E C, Davis, D G, Taylor, B B, Boak, D P, Wendel   +7 more
openaire   +2 more sources

Endoglin (CD105) Expression in Endometrial Carcinoma

International Journal of Gynecological Pathology, 2003
Tumor angiogenesis plays an important role in tumor growth and metastasis. We evaluated endoglin (CD105) as an endothelial marker of angiogenesis in endometrial carcinoma (EC) and its prognostic significance. Fifty-five cases of EC, 10 cases of complex endometrial hyperplasia with atypia (CHA), and 10 cases of simple hyperplasia (SH) were ...
Reda S, Saad, Katherine M, Jasnosz, Ming Y, Tung, Jan F, Silverman   +3 more
openaire   +2 more sources

Endoglin

AfCS-Nature Molecule Pages, 2005
Bridgette Ray, Gerard Blobe
openaire   +1 more source