Results 81 to 90 of about 13,041 (209)

Role of soluble endoglin in BMP9 signaling

Proceedings of the National Academy of Sciences, 2019
Endoglin (ENG) is a coreceptor of the transforming growth factor-β (TGFβ) family signaling complex, which is highly expressed on endothelial cells and plays a key role in angiogenesis. Its extracellular domain can be cleaved and released into the circulation as soluble ENG (sENG).
Lawera, A., Tong, Z., Thorikay, M., Redgrave, R.E., Cai, J., Dinther, M. van, Morrell, N.W., Afink, G.B., Charnock-Jones, D.S., Arthur, H.M., Dijke, P. ten, Li, W.   +11 more
openaire   +4 more sources

Endoglin missense mutants form homodimers and heterodimers with wild-type endoglin as demonstrated by BiFC.

, 2014
In order to investigate the possible assembly of mutant and wild-type (wt) homo- and heterodimers, the Bimolecular Fluorescence Complementation method was applied.
Mathias Hafner (144687), Tassilo Förg (606727), Andreas Lux (367929)   +2 more
core   +1 more source

CD133 Shapes Extracellular Vesicle Cargo and Angiogenic Function in Basal‐Like Triple‐Negative Breast Cancer

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Extracellular vesicles (EVs) are central mediators of tumour‐stroma communication, yet the mechanisms governing their biogenesis and functional cargo remain poorly understood. Here, we identify CD133 (Prominin‐1), selectively expressed in basal‐like triple‐negative breast cancer (BL‐TNBC) cells, acts as a key organizer of EV production and ...
Mireia Gomez‐Duro, Ptissam Bergam, Sara Sanchez‐Redondo, Florent Dingli, Alix Zhou, Alain Joliot, Mengliang Ye, Marta Hergueta‐Redondo, Lucas Alves Tavares, Damarys Loew, Thierry Dubois, Lorena Martin‐Jaular, Hector Peinado, Graça Raposo, Gisela D'Angelo   +14 more
wiley   +1 more source

Endoglin in HIV-associated preeclamptic placentae

Hypertension in Pregnancy, 2015
To examine the placental immunoexpression of endoglin (Eng), in HIV-negative and HIV-positive normotensive (N- and N+) and preeclamptic (P- and P+) pregnancies at term, using immunohistochemistry and immunoelectron microscopy.Strong Eng immunoreactivity was observed within endothelial cells, syncytio- and cyto-trophoblast cell populations.
Govender, Nalini, Naicker, Thajasvarie, Moodley, Jagidesa   +2 more
openaire   +2 more sources

Influence of Obstructive Sleep Apnea on Maternal and Perinatal Outcomes in Patients With Gestational Diabetes Mellitus

Journal of Sleep Research, Volume 35, Issue 3, June 2026.
ABSTRACT The prevalence of obstructive sleep apnea (OSA) increases during pregnancy and is associated with gestational diabetes mellitus (GDM), although its clinical impact on birth outcomes remains unclear. We aimed to assess the effect of several OSA criteria and intermittent hypoxia in the third trimester on perinatal outcomes in women with GDM.
María Cerdà Moncadas, Oleksandr Serednytskyy, Ainhoa Álvarez Ruiz De Larrinaga, Laura Cànaves‐Gómez, Andrés Sánchez Barón, Mercedes Codina Marcet, Mónica De La Peña Bravo, Amanda Iglesias Coma, Daniel Morell‐Garcia, José Antonio Peña Zarza, María Paloma Giménez Carrero, María Concepción Piñas Cebrian, Susana García Fernández, Francisco García‐Río, Alberto Alonso‐Fernández   +14 more
wiley   +1 more source

Circulating soluble endoglin and placental abruption [PDF]

Prenatal Diagnosis, 2008
AbstractObjectiveOur objective was to investigate whether serum concentrations of a novel anti‐angiogenic factor, soluble endoglin (sEng), could predict placental abruption.MethodsIn a nested case–control study of nulliparous pregnancies, we examined levels of sEng in serum collected prospectively from 31 women who later developed placental abruption ...
Caroline, Signore, James L, Mills, Cong, Qian, Kai F, Yu, Sarosh, Rana, S Ananth, Karumanchi, Richard J, Levine   +6 more
openaire   +2 more sources

Increased plasma soluble endoglin levels as an indicator of cardiovascular alterations in hypertensive and diabetic patients

BMC Medicine, 2010
Background Endoglin is involved in the regulation of endothelial function, but there are no studies concerning its relation with hypertension- and diabetes-associated pathologies.
Martínez-Salgado Carlos, López-Novoa José M, Sánchez-Rodríguez Angel, Recio-Rodríguez José I, García-Ortiz Luis, Gómez-Marcos Manuel A, Blázquez-Medela Ana M   +6 more
doaj   +1 more source

Endoglin (CD105) and VEGF as potential angiogenic and dissemination markers for colorectal cancer

World Journal of Surgical Oncology, 2020
Background Colorectal cancer (CRC) is an important current problem concerning public health due to its high incidence and mortality. Advances in molecular and cellular knowledge and the detection of new disease biomarkers are very important to improve ...
Ana Nogués, Eunate Gallardo-Vara, Mª. Paz Zafra, Paloma Mate, Jose Luis Marijuan, Alfredo Alonso, Luisa Mª. Botella, Mª. Isabel Prieto   +7 more
doaj   +1 more source

Excessive hypercholesterolaemia during pregnancy as a risk factor for endothelial dysfunction in pre‐eclampsia

The Journal of Physiology, Volume 604, Issue 11, Page 4302-4317, 1 June 2026.
Abstract figure legend Excessive hypercholesterolaemia during pregnancy impairs maternal endothelial function, which, in turn, drives the development of pre‐eclampsia and may also contribute to the increased risk of later‐life cardiovascular disease in women.
Amanda A. de Oliveira, Floor Spaans, Christy‐Lynn M. Cooke, Sandra T. Davidge   +3 more
wiley   +1 more source

Endoglin physically interacts with ActRIIA and BMPRII.

, 2013
After transient transfection, the surface proteins of PC3-M cells were crosslinked, cells lysed, immunoprecipitation performed, crosslinking reversed, and Western blot performed. A) ActRIIA coprecipitates with endoglin.
Xiaoke Huang (445052), Calvin P. H. Vary (445053), Michael J. Breen (445049), Diarmuid M. Moran (445050), Raymond C. Bergan (445054), Wenzhe Liu (445051)   +5 more
core   +1 more source