Results 71 to 80 of about 9,267 (204)

Navigating the Genetic Risk of Chemotherapy‐Induced Hearing Loss in the Stria Vascularis

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 846-858, April 2026.
Cisplatin is a chemotherapy drug that causes permanent hearing loss by damaging a critical tissue lining the inner ear, called the stria vascularis (SV). Currently, the molecular mechanisms of SV damage are largely unknown and the incidence of ototoxicity in patients cannot be reliably predicted.
Tara Lazetic, Deanne Nixie R. Miao, Britt I. Drögemöller, Alain Dabdoub, Julia M. Abitbol   +4 more
wiley   +1 more source

Variants encoding a restricted carboxy-terminal domain of SLC12A2 cause hereditary hearing loss in humans.

PLoS Genetics, 2020
Hereditary hearing loss is challenging to diagnose because of the heterogeneity of the causative genes. Further, some genes involved in hereditary hearing loss have yet to be identified.
Hideki Mutai, Koichiro Wasano, Yukihide Momozawa, Yoichiro Kamatani, Fuyuki Miya, Sawako Masuda, Noriko Morimoto, Kiyomitsu Nara, Satoe Takahashi, Tatsuhiko Tsunoda, Kazuaki Homma, Michiaki Kubo, Tatsuo Matsunaga   +12 more
doaj   +1 more source

Classification of European Illex coindetii and Loligo forbesii Squid Stocks by Trace Element Analysis of Statoliths

Fisheries Management and Ecology, Volume 33, Issue 2, Page 181-200, April 2026.
ABSTRACT We investigated whether statolith microchemistry analysis could classify ommastrephid and loliginid squid species into fishery stocks. Statolith nucleus (early life stage) and edge (life stage at time before catch) of Illex coindetii (Verany, 1839) and Loligo forbesii (Steenstrup, 1856) from various areas of the North East Atlantic Ocean and ...
Bianca T. C. Bobowski, Anne Marie Power, Finlay Burns, Pierluigi Carbonara, Danila Cuccu, Maria Cristina Follesa, Klaus Peter Jochum, Ana Moreno, Inna M. Sokolova, Maria Valls, Daniel Oesterwind   +10 more
wiley   +1 more source

Electrical Control of the Transduction Channels’ Gating Force in Mechanosensory Hair Cells

Advanced Science, Volume 13, Issue 16, 18 March 2026.
The inner ear's hair cells rely on mechanosensitive ion channels to convert vibrations of their hair‐bundle into electrical signals. We show that varying the electrical potential (U) across the sensory epithelium modulates a key determinant of mechanosensitivity—the gating force (FG)—by modulating the gating swing (d), ranging from the size of the ...
Achille Joliot, Laure Stickel, Pascal Martin   +2 more
wiley   +1 more source

Spontaneous Ca2+ signals in the developing mammalian cochlea of live mice under different anaesthetic regimes

Experimental Physiology, Volume 111, Issue 3, Page 1253-1267, 1 March 2026.
Abstract The pre‐hearing mouse cochlea undergoes critical periods of spontaneous Ca2+‐dependent activity that spreads across non‐sensory supporting cells and inner hair cells (IHCs). These signals have been shown to regulate not only the refinement of neural circuits along the auditory pathway towards functional maturity, but also the maturation of the
Francesca De Faveri, Walter Marcotti, Federico Ceriani   +2 more
wiley   +1 more source

A Simulation Study of Low-Intensity Focused Ultrasound for Modulating Rotational Sense Through Acoustic Streaming in Semicircular Canal: A Pilot Study

Applied Sciences
This study explores the feasibility of using low-intensity focused ultrasound (LIFU) to induce rotational sensations in the human semicircular canal (SCC) through the acoustic streaming effect.
Sion Cha, Wooksung Kim
doaj   +1 more source

Computing Endolymph Hydrodynamics During Head Impulse Test on Normal and Hydropic Vestibular Labyrinth Models

Frontiers in Neurology, 2020
Hypothesis: Build a biologic geometry based computational model to test the hypothesis that, in some circumstances, endolymphatic hydrops can mechanically cause enhanced eye velocity responses during clinical conditions of the head impulse test ...
Jorge Rey-Martinez, Xabier Altuna, Kai Cheng, Ann M. Burgess, Ian S. Curthoys   +4 more
doaj   +1 more source

Quantifying physiological influences on otolith microchemistry [PDF]

, 2015
Trace element concentrations in fish earstones (‘otoliths’) are widely used to discriminate spatially discrete populations or individuals of marine fish, based on a commonly held assumption that physiological influences on otolith composition are minor ...
Hunter, Ewan, Johnson, Rachel C, Milton, J Andrew, Sturrock, Anna M, Trueman, Clive N, Waring, Colin P   +5 more
core   +1 more source

Personalized Models of Biological Barriers and Their Diseases: Recent Progress with Organs‐On‐Chips

Advanced Biology, Volume 10, Issue 2, February 2026.
Buck and Bugter et al. explore the architectural diversity and physiological functions of human barrier systems and reveal how organ‐on‐chip platforms, particularly those integrating patient‐derived cells, are advancing barrier disease modeling. They highlight how emerging biological and technological advances can be used to bridge the gap between ...
Franziska Buck, Jeroen Bugter, Gizem Yorukoglu, Mina Kazemzadeh Dastjerd, Thomas E. Winkler   +4 more
wiley   +1 more source

Pressure relationship between perilymph and endolymph after the infusion of artificial endolymph into scala media.

Practica Oto-Rhino-Laryngologica, 1990
The pressure difference between the perilymph and the endolymph following infusion of artificial endolymph into the endolymphatic space was studied in guinea pigs. The perilymphatic and the endolymphatic pressures were measured simultaneously with two sets of a servo-pulling system.
Shunji Takeuchi, Taizo Takeda, Haruo Saito   +2 more
openaire   +2 more sources