Results 131 to 140 of about 10,232 (247)

Environmental Antimicrobial Resistance: Key Drivers, Hotspots, Innovative Strategies, and Challenges in the Fight Against Superbugs

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
Antimicrobial resistance (AMR) poses a critical threat to global health, affecting humans, animals, and the environment. This review explores major drivers and hotspots of AMR and outlines innovative strategies, including One Health–based interventions, to mitigate the spread of resistant pathogens and address this escalating worldwide health challenge.
Kindu Alem, Mulat Dagnew, Mucheye Gizachew, Baye Gelaw, Feleke Moges   +4 more
wiley   +1 more source

Activity Assays for Bacteriophage Endolysin PlyPy

BIO-PROTOCOL, 2014
Bacterial viruses (bacteriophages) escape and kill their host by degrading the bacterial peptidoglycan layer through the mechanism of enzymes called endolysins: peptidoglycan degrading enzymes. The method included here is useful for the initial characterization of any endolysin, regardless of the specific catalytic domain (as long as the activity ...
Rolf Lood, Vincent Fischetti
openaire   +2 more sources

Diversity of Endolysin Domain Architectures in Bacteriophages Infecting Bacilli

Biomolecules
The increasing number of antibiotic-resistant bacterial pathogens is a serious problem in medicine. Endolysins are bacteriolytic enzymes of bacteriophages, and a promising group of enzymes with antibacterial properties.
O. N. Koposova, O. Kazantseva, A. Shadrin   +2 more
semanticscholar   +1 more source

Phages Preying on Bacillus anthracis, Bacillus cereus, and Bacillus thuringiensis: Past, Present and Future [PDF]

, 2014
Many bacteriophages (phages) have been widely studied due to their major role in virulence evolution of bacterial pathogens. However, less attention has been paid to phages preying on bacteria from the Bacillus cereus group and their contribution to the ...
Ackermann, Ackermann, Afrikian, Ahmed, Annika Gillis, Aronson, Azizbekian, Barsomian, Barylski, Bravo, Brown, Buck, Casjens, Casjens, Ciuca, Clements, Cohen, Coman, Cowles, Delbrück, Dong, Duckworth, D’Herelle, Edintsov, El-Arabi, Farrar, Fouet, Fruciano, Fulmer, Gaal, Green, Griffiths, Grose, He, Heierson, Hendrix, Hendrix, Hulo, Inal, Inal, Jacques Mahillon, Jensen, Jones, Kanda, Kanda, Kanda, Kanda, Kellenberger, Khachatrian, King, Koretskaia, Koretskaia, Koroleva, Landén, Lavigne, Lecadet, Lecadet, Lee, Lemos Monteiro, Lemos Monteiro, Lewis, Liao, Loessner, Mahillon, Maroun, Maughan, Mccloy, Moumen, Nagy, Nakamura, Oksanen, Perlak, Pogosbekova, Priest, Raiga, Rasko, Redondo, Reynolds, Ruhfel, Sansinenea, Serwer, Shin, Sorokin, Sozhamannan, Stamatin, Stamatin, Stamatin, Stepanov, Stiube, Stiube, Sullivan, Swanson, Thorne, Thorne, Thorne, Thorne, Tikhonenko, Tikhonenko, Tikhonenko, Ting, Toschkov, Turnbull, Tyeryar, Verheust, Verheust, Walter, Watanabe, Yelton, Yelton   +108 more
core   +1 more source

Enhancing Whole Phage Therapy and Their Derived Antimicrobial Enzymes through Complex Formulation [PDF]

, 2018
The resurgence of research into phage biology and therapy is, in part, due to the increasing need for novel agents to treat multidrug-resistant infections.
Cooper, Callum, Koonjan, Shazeeda, Nilsson, Anders   +2 more
core   +1 more source

Endolysin EN572-5 as an alternative to treat urinary tract infection caused by Streptococcus agalactiae

Applied Microbiology and Biotechnology
Streptococcus agalactiae (Group B Streptococcus, GBS) is an opportunistic pathogen causing urinary tract infection (UTI). Endolysin EN572-5 was identified in prophage KMB-572-E of the human isolate Streptococcus agalactiae KMB-572.
Maria Kajsikova, M. Kajsík, Lucia Bocanova, Kristina Papayova, H. Drahovská, G. Bukovska   +5 more
semanticscholar   +1 more source

Transcriptome analysis of bacteriophage communities in periodontal health and disease. [PDF]

, 2015
BackgroundThe role of viruses as members of the human microbiome has gained broader attention with the discovery that human body surfaces are inhabited by sizeable viral communities.
Abeles, Shira R, Boehm, Tobias K, Ly, Melissa, Naidu, Mayuri, Pride, David T, Santiago-Rodriguez, Tasha M   +5 more
core   +2 more sources

Genomic analysis of Salmonella bacteriophages revealed multiple endolysin ORFs and importance of ligand-binding site of receptor-binding protein

FEMS Microbiology Ecology
Salmonella is a prevalent foodborne pathogen causing millions of global cases annually. Antimicrobial resistance is a growing public health concern, leading to search for alternatives like bacteriophages.
Mustafa Guzel, Aysenur Yucefaydali, Segâh Yetişkin, Aysu Deniz, Osman Yaşar Tel, M. Akçelik, Y. Soyer   +6 more
semanticscholar   +1 more source

Genetically modified bacteriophages [PDF]

, 2016
Phages or bacteriophages, viruses that infect and replicate inside bacteria, are the most abundant microorganisms on earth. The realization that antibiotic resistance poses a substantial risk to the world’s health and global economy is revitalizing phage
Grigonyte, Aurelija M., Jaramillo, Alfonso, MacDonald, Paul, Sagona, Antonia P.   +3 more
core   +1 more source

The preclinical and clinical progress of bacteriophages and their lytic enzymes : the parts are easier than the whole [PDF]

, 2019
The therapeutic potential of phages has been considered since their first identification more than a century ago. The evident concept of using a natural predator to treat bacterial infections has, however, since then been challenged considerably ...
Abdelkader, Karim Abdelkader Soufi, Briers, Yves, Dishisha, Tarek, Gerstmans, Hans, Saafan, Amal   +4 more
core   +1 more source