Results 1 to 10 of about 134,864 (144)

Expert consensus on genetic counseling in gynecological oncology (2023 edition) [PDF]

Zhongguo aizheng zazhi, 2023
With the increasing applications of high-throughput genome sequencing technology, there is a growing recognition of the important roles of genetic factors in the occurrence and development of gynecological tumors.

doaj   +1 more source

Expression of STAT3 in endometrial carcinoma and its clinicopathological significance [PDF]

Jichu yixue yu linchuang, 2023
Objective To investigate the expression of signal transducer and activator of transcription 3 (STAT3) in endometrial cancer tissues, and to analyze its relationship with common pathological parameters.
SUN Xinzhao, LUO Yanlu, FAN Jiangtao, ZHONG Xueyan
doaj   +1 more source

Impact of metabolic syndrome on the risk of endometrial cancer and the role of lifestyle in prevention

Biomolecules & Biomedicine, 2022
Endometrial cancer is the second gynecological cancer with the highest global incidence. Among many associated risk factors, metabolic syndrome is an important and preventable one.
Alejandra Rocío Pérez-Martín, Denisse Castro-Eguiluz , Lucely Cetina-Pérez, Yadira Velasco-Torres, Antonio Bahena-González, Edgar Montes-Servín, Ernesto González-Ibarra, Raquel Espinosa-Romero, Dolores Gallardo-Rincón   +8 more
doaj   +1 more source

Clinical Benefits of Olaparib in Mexican Ovarian Cancer Patients With Founder Mutation BRCA1-Del ex9-12

Frontiers in Genetics, 2022
Background: Ovarian cancer (OC) is gynecologic cancer with the highest mortality rate. It is estimated that 13–17% of ovarian cancers are due to heritable mutations in BRCA1 and BRCA2.
Dolores Gallardo-Rincón, Dolores Gallardo-Rincón, Edgar Montes-Servín, Gabriela Alamilla-García, Gabriela Alamilla-García, Elizabeth Montes-Servín, Antonio Bahena-González, Antonio Bahena-González, Lucely Cetina-Pérez, Lucely Cetina-Pérez, Flavia Morales Vásquez, Claudia Cano-Blanco, Jaime Coronel-Martínez, Ernesto González-Ibarra, Raquel Espinosa-Romero, Raquel Espinosa-Romero, Rosa María Alvarez-Gómez, Rosa María Alvarez-Gómez, Abraham Pedroza-Torres, Abraham Pedroza-Torres, Denisse Castro-Eguiluz, Denisse Castro-Eguiluz   +21 more
doaj   +1 more source

Risk of Endometrial Cancer and Frequencies of Invasive Endometrial Procedures in Young Breast Cancer Survivors Treated With Tamoxifen: A Nationwide Study

Frontiers in Oncology, 2021
BackgroundAlthough the guidelines recommend gynecological assessment and close monitoring for symptoms of endometrial cancer in postmenopausal breast cancer survivors taking tamoxifen (TAM), the risk of endometrial cancer in young breast cancer survivors
Soojeong Choi, Young Jae Lee, Jae Ho Jeong, Jinhong Jung, Jong Won Lee, Hee Jeong Kim, Beom Seok Ko, Byung Ho Son, Sei Hyun Ahn, Yura Lee, Yura Lee, Il Yong Chung   +11 more
doaj   +1 more source

Pathology findings among women with alterations in uterine bleeding patterns in cameroon

Gynecologic Oncology Reports, 2021
Purpose: Endometrial cancer is on the rise in high-income countries but it has not been adequately studied in low-and-middle income countries especially in sub-Saharan Africa (SSA), likely due to scarce pathology facilities. The purpose of this study was
Simon M. Manga, Yuanfan Ye, Jeff M. Szychowski, Kathleen L. Nulah, Calvin Ngalla, Kaitlyn Kincaid, Teresa K.L. Boitano, Alan T. Tita, Isabel Scarinci, Warner K. Huh, Zacharie Sando, Margaret I. Liang   +11 more
doaj   +1 more source

Endometrial cancer PDX-derived organoids (PDXOs) and PDXs with FGFR2c isoform expression are sensitive to FGFR inhibition

npj Precision Oncology, 2023
Endometrial cancer (EC) patients with metastatic/recurrent disease have limited treatment options and poor survival outcomes. Recently, we discovered the FGFR2c splice isoform is associated with poor prognosis in EC patients.
Asmerom T. Sengal, Vanessa Bonazzi, Deborah Smith, Cristian P. Moiola, Rohan Lourie, Rebecca Rogers, Eva Colas, Antonio Gil-Moreno, Sophia Frentzas, Naven Chetty, Lewis Perrin, Pamela M. Pollock   +11 more
doaj   +1 more source

Multi-trait genome-wide association study identifies a novel endometrial cancer risk locus that associates with testosterone levels

iScience, 2023
Summary: To detect novel endometrial cancer risk variants, we leveraged information from endometrial cancer risk factors in a multi-trait GWAS analysis.
Xuemin Wang, Pik Fang Kho, Dhanya Ramachandran, Cemsel Bafligil, Frederic Amant, Ellen L. Goode, Rodney J. Scott, Ian Tomlinson, D. Gareth Evans, Emma J. Crosbie, Thilo Dörk, Amanda B. Spurdle, Dylan M. Glubb, Tracy A. O'Mara   +13 more
doaj   +1 more source

Clinicopathological and ultrasound features of endometrial cancer in postmenopausal women: a retrospective study in a single institute in South Korea

The Pan African Medical Journal, 2021
INTRODUCTION: Endometrial cancer is the most common type of cancer in the female genital tract. Most patients are diagnosed during postmenopausal periods. To investigate the demographic characteristics as well as cutoff value of endometrial thickness and
Hyen Chul Jo, Jong Chul Baek, Seon Mi Lee, Ji Eun Park, In Ae Cho, Joo Hyun Sung   +5 more
doaj   +1 more source

Hypoxia and hyperglycaemia determine why some endometrial tumours fail to respond to metformin [PDF]

, 2020
High expression of Ki67, a proliferation marker, is associated with reduced endometrial cancer-specific survival. Pre-surgical metformin reduces tumour Ki-67 expression in some women with endometrial cancer. Metformin's anti-cancer activity may relate to
Crosbie, EJ, Finegan, KG, Kitson, S, Latif, A, Lisanti, MP, Marshall, K, McVey, R, Sivalingam, VN, Sotgia, F, Stratford, IJ   +9 more
core   +2 more sources