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Role of metabolic syndrome and lifestyle factors in endometrial cancer risk and prevention [PDF]
Quality in SportIntroduction: The incidence of endometrial cancer, the sixth most common cancer among women, has been rising, especially in developed countries, possibly due to the obesity and diabetes pandemic.
Anita Kwiatkowska +9 more
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Canadian Medical Association Journal, 2021 Although endometrial cancer management remains challenging, a deeper understanding of the genetic diversity as well as the drivers of the various pathogenic states of this disease has led to development of divergent management approaches in an effort to improve therapeutic precision in this complex malignancy.
Sobel, Mara +2 more
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Role of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development. [PDF]
PLoS Medicine, 2013 BackgroundEndometrial cancer incidence is continuing to rise in the wake of the current ageing and obesity epidemics. Much of the risk for endometrial cancer development is influenced by the environment and lifestyle.
Allison Jones +21 more
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Targeting the splicing factor SNRPB inhibits endometrial cancer progression by retaining the POLD1 intron [PDF]
Experimental and Molecular MedicineDysregulated alternative splicing has been closely linked to the initiation and progression of tumors. Nevertheless, the precise molecular mechanisms through which splicing factors regulate endometrial cancer progression are still not fully understood ...
Yingwei Li +8 more
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Germline copy number variants and endometrial cancer risk. [PDF]
Hum GenetKnown risk loci for endometrial cancer explain approximately one third of familial endometrial cancer. However, the association of germline copy number variants (CNVs) with endometrial cancer risk remains relatively unknown.
Stylianou CE +38 more
europepmc +3 more sources
Expert consensus on genetic counseling in gynecological oncology (2023 edition) [PDF]
Zhongguo aizheng zazhi, 2023 With the increasing applications of high-throughput genome sequencing technology, there is a growing recognition of the important roles of genetic factors in the occurrence and development of gynecological tumors.
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Best Practice & Research Clinical Obstetrics & Gynaecology, 2012 Endometrial carcinoma is the most common gynaecological malignancy in the Western world. The standard management of endometrial carcinoma is total hysterectomy and bilateral salpingo-oophorectomy with or without pelvic and para-aortic lymph-node dissection.
Vivek, Arora, Michael A, Quinn
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Expression of STAT3 in endometrial carcinoma and its clinicopathological significance [PDF]
Jichu yixue yu linchuang, 2023 Objective To investigate the expression of signal transducer and activator of transcription 3 (STAT3) in endometrial cancer tissues, and to analyze its relationship with common pathological parameters.
SUN Xinzhao, LUO Yanlu, FAN Jiangtao, ZHONG Xueyan
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The Lancet, 2022 Endometrial cancer is the most common gynaecological cancer in high income countries and its incidence is rising globally. Although an ageing population and fewer benign hysterectomies have contributed to this trend, the growing prevalence of obesity is the major underlying cause.
Crosbie, Emma J +5 more
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The Lancet, 2005 Each year, endometrial cancer develops in about 142,000 women worldwide, and an estimated 42,000 women die from this cancer. The typical age-incidence curve for endometrial cancer shows that most cases are diagnosed after the menopause, with the highest incidence around the seventh decade of life. The appearance of symptoms early in the course explains
Amant, Frédéric +5 more
openaire +5 more sources