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The Lancet, 2022 Endometrial cancer is the most common gynaecological cancer in high income countries and its incidence is rising globally. Although an ageing population and fewer benign hysterectomies have contributed to this trend, the growing prevalence of obesity is the major underlying cause.
Crosbie, Emma J +5 more
semanticscholar +6 more sources
New England Journal of Medicine, 2021 Although endometrial cancer management remains challenging, a deeper understanding of the genetic diversity as well as the drivers of the various pathogenic states of this disease has led to development of divergent management approaches in an effort to improve therapeutic precision in this complex malignancy.
Karen H. Lu, Russell Broaddus
semanticscholar +10 more sources
Germline copy number variants and endometrial cancer risk. [PDF]
Hum GenetKnown risk loci for endometrial cancer explain approximately one third of familial endometrial cancer. However, the association of germline copy number variants (CNVs) with endometrial cancer risk remains relatively unknown.
Stylianou CE +38 more
europepmc +3 more sources
The Role of Metabolic Syndrome in Endometrial Cancer: A Review
Frontiers in Oncology, 2019 Endometrial cancer is one of the most common cancers of the female reproductive system. Although surgery, radiotherapy, chemotherapy, and hormone therapy can significantly improve the survival of patients, the treatment of patients with very early ...
Xiao Yang, Jianliu Wang
doaj +2 more sources
Role of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development. [PDF]
PLoS Medicine, 2013 BackgroundEndometrial cancer incidence is continuing to rise in the wake of the current ageing and obesity epidemics. Much of the risk for endometrial cancer development is influenced by the environment and lifestyle.
Allison Jones +21 more
doaj +3 more sources
Adjuvant chemotherapy plus radiation for locally advanced endometrial cancer [PDF]
New England Journal of Medicine, 2019 BACKGROUND Stage III or IVA endometrial cancer carries a significant risk of systemic and locoregional recurrence. METHODS In this randomized phase 3 trial, we tested whether 6 months of platinum-based chemotherapy plus radiation therapy ...
al, et, Mutch, David, Powell, Matthew A.
core +3 more sources
Expert consensus on genetic counseling in gynecological oncology (2023 edition) [PDF]
Zhongguo aizheng zazhi, 2023 With the increasing applications of high-throughput genome sequencing technology, there is a growing recognition of the important roles of genetic factors in the occurrence and development of gynecological tumors.
doaj +1 more source
Best Practice & Research Clinical Obstetrics & Gynaecology, 2012 Endometrial carcinoma is the most common gynaecological malignancy in the Western world. The standard management of endometrial carcinoma is total hysterectomy and bilateral salpingo-oophorectomy with or without pelvic and para-aortic lymph-node dissection.
Vivek, Arora, Michael A, Quinn
+10 more sources
Expression of STAT3 in endometrial carcinoma and its clinicopathological significance [PDF]
Jichu yixue yu linchuang, 2023 Objective To investigate the expression of signal transducer and activator of transcription 3 (STAT3) in endometrial cancer tissues, and to analyze its relationship with common pathological parameters.
SUN Xinzhao, LUO Yanlu, FAN Jiangtao, ZHONG Xueyan
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The Lancet, 2005 Each year, endometrial cancer develops in about 142,000 women worldwide, and an estimated 42,000 women die from this cancer. The typical age-incidence curve for endometrial cancer shows that most cases are diagnosed after the menopause, with the highest incidence around the seventh decade of life. The appearance of symptoms early in the course explains
Amant, Frédéric +5 more
openaire +5 more sources